ID:RAMP3_HUMAN DESCRIPTION: RecName: Full=Receptor activity-modifying protein 3; AltName: Full=Calcitonin-receptor-like receptor activity-modifying protein 3; Short=CRLR activity-modifying protein 3; Flags: Precursor; FUNCTION: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. SUBUNIT: Heterodimer of CALCRL and RAMP3 (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Strongly expressed in lung, breast, immune system and fetal tissues. SIMILARITY: Belongs to the RAMP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04901 - Receptor activity modifying family
ModBase Predicted Comparative 3D Structure on O60896
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001921 positive regulation of receptor recycling GO:0006816 calcium ion transport GO:0006886 intracellular protein transport GO:0007186 G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0010628 positive regulation of gene expression GO:0010739 positive regulation of protein kinase A signaling GO:0010942 positive regulation of cell death GO:0015031 protein transport GO:0030816 positive regulation of cAMP metabolic process GO:0031623 receptor internalization GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0038041 cross-receptor inhibition within G-protein coupled receptor heterodimer GO:0051897 positive regulation of protein kinase B signaling GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071392 cellular response to estradiol stimulus GO:0072659 protein localization to plasma membrane GO:0086103 G-protein coupled receptor signaling pathway involved in heart process GO:0097647 amylin receptor signaling pathway GO:1903078 positive regulation of protein localization to plasma membrane GO:1905665 positive regulation of calcium ion import across plasma membrane GO:1990410 adrenomedullin receptor signaling pathway
AJ001016 - Homo sapiens mRNA encoding RAMP3. BC022304 - Homo sapiens receptor (G protein-coupled) activity modifying protein 3, mRNA (cDNA clone MGC:22548 IMAGE:4717934), complete cds. BC053852 - Homo sapiens receptor (G protein-coupled) activity modifying protein 3, mRNA (cDNA clone MGC:61457 IMAGE:6197363), complete cds. AK222469 - Homo sapiens mRNA for receptor (calcitonin) activity modifying protein 3 precursor variant, clone: adKA02144. DQ891371 - Synthetic construct clone IMAGE:100004001; FLH176304.01X; RZPDo839B10122D receptor (calcitonin) activity modifying protein 3 (RAMP3) gene, encodes complete protein. HQ448585 - Synthetic construct Homo sapiens clone IMAGE:100072023; CCSB011921_01 receptor (G protein-coupled) activity modifying protein 3 (RAMP3) gene, encodes complete protein. KJ892983 - Synthetic construct Homo sapiens clone ccsbBroadEn_02377 RAMP3 gene, encodes complete protein. CU691036 - Synthetic construct Homo sapiens gateway clone IMAGE:100021539 5' read RAMP3 mRNA. KJ898187 - Synthetic construct Homo sapiens clone ccsbBroadEn_07581 RAMP3 gene, encodes complete protein. AK311871 - Homo sapiens cDNA, FLJ92137, Homo sapiens receptor (calcitonin) activity modifying protein 3(RAMP3), mRNA. AY265459 - Homo sapiens receptor calcitonin activity modifying protein 3 (RAMP3) mRNA, complete cds. JD026047 - Sequence 7071 from Patent EP1572962. AK128765 - Homo sapiens cDNA FLJ45216 fis, clone BRCAN2019351, highly similar to Homo sapiens receptor (calcitonin) activity modifying protein 3 (RAMP3). JD409567 - Sequence 390591 from Patent EP1572962. JD114758 - Sequence 95782 from Patent EP1572962. JD164190 - Sequence 145214 from Patent EP1572962. JD399182 - Sequence 380206 from Patent EP1572962. JD338421 - Sequence 319445 from Patent EP1572962. JD198855 - Sequence 179879 from Patent EP1572962. JD322700 - Sequence 303724 from Patent EP1572962. JD454707 - Sequence 435731 from Patent EP1572962. JD325262 - Sequence 306286 from Patent EP1572962. JD155664 - Sequence 136688 from Patent EP1572962. JD231349 - Sequence 212373 from Patent EP1572962. JD427253 - Sequence 408277 from Patent EP1572962. JD480215 - Sequence 461239 from Patent EP1572962. JD062714 - Sequence 43738 from Patent EP1572962. JD544455 - Sequence 525479 from Patent EP1572962. JD219045 - Sequence 200069 from Patent EP1572962. JD378341 - Sequence 359365 from Patent EP1572962. JD538470 - Sequence 519494 from Patent EP1572962. JD497420 - Sequence 478444 from Patent EP1572962. JD134688 - Sequence 115712 from Patent EP1572962. JD079418 - Sequence 60442 from Patent EP1572962. JD270913 - Sequence 251937 from Patent EP1572962. JD386380 - Sequence 367404 from Patent EP1572962. JD439111 - Sequence 420135 from Patent EP1572962. JD399047 - Sequence 380071 from Patent EP1572962. JD282813 - Sequence 263837 from Patent EP1572962. JD497400 - Sequence 478424 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60896 (Reactome details) participates in the following event(s):
R-HSA-420214 The adrenomedullin receptor can bind adrenomedullin and intermedin R-HSA-420265 Amylin receptors can bind Amylin R-HSA-744886 The Ligand:GPCR:Gs complex dissociates R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs R-HSA-419812 Calcitonin-like ligand receptors R-HSA-418555 G alpha (s) signalling events R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-388396 GPCR downstream signalling R-HSA-500792 GPCR ligand binding R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
