Human Gene RAE1 (ENST00000395841.7_4) from GENCODE V47lift37
  Description: ribonucleic acid export 1, transcript variant 1 (from RefSeq NM_003610.4)
Gencode Transcript: ENST00000395841.7_4
Gencode Gene: ENSG00000101146.13_9
Transcript (Including UTRs)
   Position: hg19 chr20:55,926,311-55,954,258 Size: 27,948 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr20:55,929,095-55,953,155 Size: 24,061 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:55,926,311-55,954,258)mRNA (may differ from genome)Protein (368 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RAE1L_HUMAN
DESCRIPTION: RecName: Full=mRNA export factor; AltName: Full=Rae1 protein homolog; AltName: Full=mRNA-associated protein mrnp 41;
FUNCTION: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
SUBUNIT: Interacts with NUP98.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
SIMILARITY: Belongs to the WD repeat rae1 family.
SIMILARITY: Contains 7 WD repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.58 RPKM in Testis
Total median expression: 437.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.30175-0.345 Picture PostScript Text
3' UTR -341.301103-0.309 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50370 - Ricin B-like lectins
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3MMY - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P78406
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0043130 ubiquitin binding

Biological Process:
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0007049 cell cycle
GO:0016032 viral process
GO:0051301 cell division
GO:0060236 regulation of mitotic spindle organization
GO:0071407 cellular response to organic cyclic compound

Cellular Component:
GO:0000922 spindle pole
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0097431 mitotic spindle pole


-  Descriptions from all associated GenBank mRNAs
  AK307966 - Homo sapiens cDNA, FLJ97914.
BC103754 - Homo sapiens RAE1 RNA export 1 homolog (S. pombe), mRNA (cDNA clone MGC:117333 IMAGE:6501538), complete cds.
AK309743 - Homo sapiens cDNA, FLJ99784.
U85943 - Homo sapiens mRNA-associated protein mrnp41 mRNA, complete cds.
AK309069 - Homo sapiens cDNA, FLJ99110.
U84720 - Homo sapiens mRNA export protein (RAE1) mRNA, complete cds.
BC106923 - Homo sapiens RAE1 RNA export 1 homolog (S. pombe), mRNA (cDNA clone MGC:126076 IMAGE:40032941), complete cds.
BC106924 - Homo sapiens RAE1 RNA export 1 homolog (S. pombe), mRNA (cDNA clone MGC:126077 IMAGE:40032942), complete cds.
JD055987 - Sequence 37011 from Patent EP1572962.
AK292247 - Homo sapiens cDNA FLJ75499 complete cds, highly similar to Homo sapiens RAE1 RNA export 1 homolog (S. pombe) (RAE1), mRNA.
AY349350 - Homo sapiens RNA export 1-like protein mRNA, complete cds.
FW420959 - A use of PSMA7, NEDD1, and RAE1 as the gene expression suppressant.
LF383780 - JP 2014500723-A/191283: Polycomb-Associated Non-Coding RNAs.
AY336091 - Homo sapiens migration-inducing gene 14 mRNA, complete cds.
LF210970 - JP 2014500723-A/18473: Polycomb-Associated Non-Coding RNAs.
AB528558 - Synthetic construct DNA, clone: pF1KB5360, Homo sapiens RAE1 gene for mRNA export factor, without stop codon, in Flexi system.
KJ892542 - Synthetic construct Homo sapiens clone ccsbBroadEn_01936 RAE1 gene, encodes complete protein.
LF342693 - JP 2014500723-A/150196: Polycomb-Associated Non-Coding RNAs.
LF350799 - JP 2014500723-A/158302: Polycomb-Associated Non-Coding RNAs.
AK126024 - Homo sapiens cDNA FLJ44036 fis, clone TESTI4028809.
LF342695 - JP 2014500723-A/150198: Polycomb-Associated Non-Coding RNAs.
LF350801 - JP 2014500723-A/158304: Polycomb-Associated Non-Coding RNAs.
LF350802 - JP 2014500723-A/158305: Polycomb-Associated Non-Coding RNAs.
LF350803 - JP 2014500723-A/158306: Polycomb-Associated Non-Coding RNAs.
AK055170 - Homo sapiens cDNA FLJ30608 fis, clone CTONG2000465.
LF350804 - JP 2014500723-A/158307: Polycomb-Associated Non-Coding RNAs.
JD038494 - Sequence 19518 from Patent EP1572962.
JD526852 - Sequence 507876 from Patent EP1572962.
JD248684 - Sequence 229708 from Patent EP1572962.
JD334649 - Sequence 315673 from Patent EP1572962.
JD331385 - Sequence 312409 from Patent EP1572962.
JD235702 - Sequence 216726 from Patent EP1572962.
JD129600 - Sequence 110624 from Patent EP1572962.
JD184563 - Sequence 165587 from Patent EP1572962.
JD300734 - Sequence 281758 from Patent EP1572962.
MA619357 - JP 2018138019-A/191283: Polycomb-Associated Non-Coding RNAs.
MA578270 - JP 2018138019-A/150196: Polycomb-Associated Non-Coding RNAs.
MA586376 - JP 2018138019-A/158302: Polycomb-Associated Non-Coding RNAs.
MA578272 - JP 2018138019-A/150198: Polycomb-Associated Non-Coding RNAs.
MA586378 - JP 2018138019-A/158304: Polycomb-Associated Non-Coding RNAs.
MA586379 - JP 2018138019-A/158305: Polycomb-Associated Non-Coding RNAs.
MA586380 - JP 2018138019-A/158306: Polycomb-Associated Non-Coding RNAs.
MA586381 - JP 2018138019-A/158307: Polycomb-Associated Non-Coding RNAs.
MA446547 - JP 2018138019-A/18473: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P78406 (Reactome details) participates in the following event(s):

R-HSA-75096 Docking of the TAP:EJC Complex with the NPC
R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
R-HSA-180622 Vpr binds nucleoporins
R-HSA-180710 Rev:importin beta:B23 recruited to the nuclear pore
R-HSA-2990882 CDK1 phosphorylates NUP98
R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC
R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm
R-HSA-180732 Translocation of Rev:importin-beta:B23 to the nucleus
R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98
R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm
R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus
R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2
R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1
R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2
R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1
R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1
R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3
R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1
R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1
R-HSA-192627 Viral mRNA Export
R-HSA-192925 Export of Spliced Viral mRNA
R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-180746 Nuclear import of Rev protein
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-162587 HIV Life Cycle
R-HSA-162909 Host Interactions of HIV factors
R-HSA-68875 Mitotic Prophase
R-HSA-70171 Glycolysis
R-HSA-168253 Host Interactions with Influenza Factors
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-211000 Gene Silencing by RNA
R-HSA-72306 tRNA processing
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-3371556 Cellular response to heat stress
R-HSA-8953854 Metabolism of RNA
R-HSA-162906 HIV Infection
R-HSA-68886 M Phase
R-HSA-70326 Glucose metabolism
R-HSA-168254 Influenza Infection
R-HSA-913531 Interferon Signaling
R-HSA-74160 Gene expression (Transcription)
R-HSA-2990846 SUMOylation
R-HSA-168255 Influenza Life Cycle
R-HSA-2262752 Cellular responses to stress
R-HSA-5663205 Infectious disease
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-597592 Post-translational protein modification
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1643685 Disease
R-HSA-1640170 Cell Cycle
R-HSA-1430728 Metabolism
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A8K882, ENST00000395841.1, ENST00000395841.2, ENST00000395841.3, ENST00000395841.4, ENST00000395841.5, ENST00000395841.6, MRNP41, NM_003610, O15306, P78406, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6, RAE1L_HUMAN, uc318xts.1, uc318xts.2
UCSC ID: ENST00000395841.7_4
RefSeq Accession: NM_003610.4
Protein: P78406 (aka RAE1L_HUMAN or RA1L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.