ID:RAC2_HUMAN DESCRIPTION: RecName: Full=Ras-related C3 botulinum toxin substrate 2; AltName: Full=GX; AltName: Full=Small G protein; AltName: Full=p21-Rac2; Flags: Precursor; FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. ENZYME REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. SUBUNIT: Interacts with DOCK2, which may activate it. Interacts with S100A8 and calprotectin (S100A8/9). SUBCELLULAR LOCATION: Cytoplasm. Note=Membrane-associated when activated. TISSUE SPECIFICITY: Hematopoietic specific. DISEASE: Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:608203]. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAC2ID42021ch22q13.html"; WEB RESOURCE: Name=RAC2base; Note=RAC2 mutation db; URL="http://bioinf.uta.fi/RAC2base/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15153
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006935 chemotaxis GO:0007015 actin filament organization GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007264 small GTPase mediated signal transduction GO:0008284 positive regulation of cell proliferation GO:0010310 regulation of hydrogen peroxide metabolic process GO:0010592 positive regulation of lamellipodium assembly GO:0010810 regulation of cell-substrate adhesion GO:0030031 cell projection assembly GO:0030036 actin cytoskeleton organization GO:0042129 regulation of T cell proliferation GO:0043304 regulation of mast cell degranulation GO:0045453 bone resorption GO:0045859 regulation of protein kinase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0060263 regulation of respiratory burst GO:0060753 regulation of mast cell chemotaxis GO:0071593 lymphocyte aggregation GO:0090023 positive regulation of neutrophil chemotaxis GO:1902622 regulation of neutrophil migration GO:1903955 positive regulation of protein targeting to mitochondrion
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
