Human Gene RAB14 (ENST00000373840.9_7) from GENCODE V47lift37
  Description: RAB14, member RAS oncogene family (from RefSeq NM_016322.4)
Gencode Transcript: ENST00000373840.9_7
Gencode Gene: ENSG00000119396.12_12
Transcript (Including UTRs)
   Position: hg19 chr9:123,940,411-123,964,147 Size: 23,737 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr9:123,943,674-123,955,690 Size: 12,017 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:123,940,411-123,964,147)mRNA (may differ from genome)Protein (215 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RAB14_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-14;
FUNCTION: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion.
SUBUNIT: Interacts with KIF16B (By similarity). Interacts with ZFYVE20.
SUBCELLULAR LOCATION: Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side (By similarity). Golgi apparatus, trans- Golgi network membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to recycling endosomes by DENND6A.
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
SEQUENCE CAUTION: Sequence=CAI12361.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RAB14
Diseases sorted by gene-association score: chlamydia (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.35 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 1363.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.20238-0.333 Picture PostScript Text
3' UTR -783.203263-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
56281 - Metallo-hydrolase/oxidoreductase

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1Z0F - X-ray MuPIT 4DRZ - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P61106
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0031489 myosin V binding

Biological Process:
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006895 Golgi to endosome transport
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009790 embryo development
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030100 regulation of endocytosis
GO:0032456 endocytic recycling
GO:0032880 regulation of protein localization
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0046907 intracellular transport
GO:0090382 phagosome maturation

Cellular Component:
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
GO:0043231 intracellular membrane-bounded organelle
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0005929 cilium


-  Descriptions from all associated GenBank mRNAs
  AL162081 - Homo sapiens mRNA; cDNA DKFZp762K0911 (from clone DKFZp762K0911).
JD493625 - Sequence 474649 from Patent EP1572962.
JD078158 - Sequence 59182 from Patent EP1572962.
JD509511 - Sequence 490535 from Patent EP1572962.
JD053357 - Sequence 34381 from Patent EP1572962.
JD308806 - Sequence 289830 from Patent EP1572962.
JD111157 - Sequence 92181 from Patent EP1572962.
AK000447 - Homo sapiens cDNA FLJ20440 fis, clone KAT04778.
AF052113 - Homo sapiens clone 23675 mRNA sequence.
AK023524 - Homo sapiens cDNA FLJ13462 fis, clone PLACE1003394, highly similar to Homo sapiens RAB14 protein (RAB14) mRNA.
AK090889 - Homo sapiens cDNA FLJ33570 fis, clone BRAMY2010366, highly similar to RAS-RELATED PROTEIN RAB-14.
AL110256 - Homo sapiens mRNA; cDNA DKFZp566N1346 (from clone DKFZp566N1346).
JD330241 - Sequence 311265 from Patent EP1572962.
JD423249 - Sequence 404273 from Patent EP1572962.
JD429131 - Sequence 410155 from Patent EP1572962.
JD467715 - Sequence 448739 from Patent EP1572962.
JD302198 - Sequence 283222 from Patent EP1572962.
JD244987 - Sequence 226011 from Patent EP1572962.
JD221122 - Sequence 202146 from Patent EP1572962.
JD545320 - Sequence 526344 from Patent EP1572962.
JD183505 - Sequence 164529 from Patent EP1572962.
JD279813 - Sequence 260837 from Patent EP1572962.
JD188480 - Sequence 169504 from Patent EP1572962.
JD333687 - Sequence 314711 from Patent EP1572962.
JD183270 - Sequence 164294 from Patent EP1572962.
JD516392 - Sequence 497416 from Patent EP1572962.
JD224757 - Sequence 205781 from Patent EP1572962.
JD109825 - Sequence 90849 from Patent EP1572962.
JD284352 - Sequence 265376 from Patent EP1572962.
JD510311 - Sequence 491335 from Patent EP1572962.
JD515587 - Sequence 496611 from Patent EP1572962.
AF112206 - Homo sapiens ras-related protein rab-14 mRNA, complete cds.
AF203689 - Homo sapiens GTPase Rab14 mRNA, complete cds.
BC006081 - Homo sapiens RAB14, member RAS oncogene family, mRNA (cDNA clone MGC:12573 IMAGE:2963119), complete cds.
BC013057 - Homo sapiens cDNA clone IMAGE:3859070, containing frame-shift errors.
JD566422 - Sequence 547446 from Patent EP1572962.
JD287374 - Sequence 268398 from Patent EP1572962.
JD166672 - Sequence 147696 from Patent EP1572962.
JD342534 - Sequence 323558 from Patent EP1572962.
AF152463 - Homo sapiens RAB14 protein (RAB14) mRNA, complete cds.
AF498949 - Homo sapiens small GTP binding protein RAB14 (RAB14) mRNA, complete cds.
AY553875 - Homo sapiens F protein-binding protein 1 mRNA, complete cds.
KJ898922 - Synthetic construct Homo sapiens clone ccsbBroadEn_08316 RAB14 gene, encodes complete protein.
AB528836 - Synthetic construct DNA, clone: pF1KE0461, Homo sapiens RAB14 gene for RAB14, member RAS oncogene family, without stop codon, in Flexi system.
AM393292 - Synthetic construct Homo sapiens clone IMAGE:100002372 for hypothetical protein (RAB14 gene).
AM393350 - Synthetic construct Homo sapiens clone IMAGE:100002371 for hypothetical protein (RAB14 gene).
CR457394 - Homo sapiens full open reading frame cDNA clone RZPDo834G0710D for gene RAB14, RAB14, member RAS oncogene family; complete cds, incl. stopcodon.
CU675229 - Synthetic construct Homo sapiens gateway clone IMAGE:100020208 5' read RAB14 mRNA.
DQ579464 - Homo sapiens piRNA piR-47576, complete sequence.
LF358404 - JP 2014500723-A/165907: Polycomb-Associated Non-Coding RNAs.
MA593981 - JP 2018138019-A/165907: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P61106 (Reactome details) participates in the following event(s):

R-HSA-6798747 Exocytosis of tertiary granule membrane proteins
R-HSA-8871366 p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP
R-HSA-8876616 DENND6A,B exchange GTP for GDP on RAB14
R-HSA-2255343 RAB8A,10,13,14 exchange GDP for GTP
R-HSA-1445143 RAB8A,10,13,14 hydrolyze GTP
R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-168249 Innate Immune System
R-HSA-1483255 PI Metabolism
R-HSA-8873719 RAB geranylgeranylation
R-HSA-9007101 Rab regulation of trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-168256 Immune System
R-HSA-1483257 Phospholipid metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-5653656 Vesicle-mediated transport
R-HSA-556833 Metabolism of lipids
R-HSA-392499 Metabolism of proteins
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B3KR31, ENST00000373840.1, ENST00000373840.2, ENST00000373840.3, ENST00000373840.4, ENST00000373840.5, ENST00000373840.6, ENST00000373840.7, ENST00000373840.8, NM_016322, P35287, P61106, Q5JVD4, Q6Q7K5, Q969L0, Q9UI11, RAB14_HUMAN, uc318lcj.1, uc318lcj.2
UCSC ID: ENST00000373840.9_7
RefSeq Accession: NM_016322.4
Protein: P61106 (aka RAB14_HUMAN or RB14_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.