Human Gene PTTG1 (ENST00000352433.10_4) from GENCODE V47lift37
  Description: PTTG1 regulator of sister chromatid separation, securin, transcript variant 2 (from RefSeq NM_004219.4)
Gencode Transcript: ENST00000352433.10_4
Gencode Gene: ENSG00000164611.13_8
Transcript (Including UTRs)
   Position: hg19 chr5:159,848,862-159,855,746 Size: 6,885 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr5:159,849,320-159,855,688 Size: 6,369 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:159,848,862-159,855,746)mRNA (may differ from genome)Protein (202 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PTTG1
Diseases sorted by gene-association score: thyroid cancer (5), pituitary adenoma, prolactin-secreting (3), thymic hyperplasia (2), thyroid cancer, nonmedullary, 2 (2), esophageal cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 78.51 RPKM in Testis
Total median expression: 263.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.6048-0.242 Picture PostScript Text
3' UTR -4.8058-0.083 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018008 - Securin_separation-inh_met
IPR006940 - Securin_separation_inhibitor

Pfam Domains:
PF04856 - Securin sister-chromatid separation inhibitor

ModBase Predicted Comparative 3D Structure on Q6IAL9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051276 chromosome organization

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK312209 - Homo sapiens cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA.
AF062649 - Homo sapiens pituitary tumor transforming gene protein (PTTG) mRNA, complete cds.
BC026003 - Homo sapiens cDNA clone IMAGE:4673542, containing frame-shift errors.
JD462558 - Sequence 443582 from Patent EP1572962.
LF384718 - JP 2014500723-A/192221: Polycomb-Associated Non-Coding RNAs.
AF095287 - Homo sapiens pituitary tumor transforming gene protein 1 (PTTG1) mRNA, complete cds.
BC101834 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone MGC:126883 IMAGE:8069340), complete cds.
BC112071 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone MGC:138276 IMAGE:8327539), complete cds.
AF075242 - Homo sapiens tumor transforming protein 1 (TUTR1) mRNA, complete cds.
AJ223953 - Homo sapiens mRNA for hPTTG protein.
BC108894 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone IMAGE:40002809), partial cds.
BC108895 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone IMAGE:40002810), partial cds.
BC113842 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone IMAGE:40002812), partial cds.
BC113896 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone IMAGE:40002811), partial cds.
AB464025 - Synthetic construct DNA, clone: pF1KB7557, Homo sapiens PTTG1 gene for pituitary tumor-transforming 1, without stop codon, in Flexi system.
CR541685 - Homo sapiens full open reading frame cDNA clone RZPDo834B0728D for gene PTTG1, pituitary tumor-transforming 1; complete cds, without stopcodon.
KJ892721 - Synthetic construct Homo sapiens clone ccsbBroadEn_02115 PTTG1 gene, encodes complete protein.
BC128193 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone MGC:149305 IMAGE:40113885), complete cds.
BC128194 - Homo sapiens pituitary tumor-transforming 1, mRNA (cDNA clone MGC:149306 IMAGE:40113886), complete cds.
CR457135 - Homo sapiens full open reading frame cDNA clone RZPDo834G127D for gene PTTG1, pituitary tumor-transforming 1; complete cds, incl. stopcodon.
LF325442 - JP 2014500723-A/132945: Polycomb-Associated Non-Coding RNAs.
LF325441 - JP 2014500723-A/132944: Polycomb-Associated Non-Coding RNAs.
LF325439 - JP 2014500723-A/132942: Polycomb-Associated Non-Coding RNAs.
MA620295 - JP 2018138019-A/192221: Polycomb-Associated Non-Coding RNAs.
MA561019 - JP 2018138019-A/132945: Polycomb-Associated Non-Coding RNAs.
MA561018 - JP 2018138019-A/132944: Polycomb-Associated Non-Coding RNAs.
MA561016 - JP 2018138019-A/132942: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000352433.1, ENST00000352433.2, ENST00000352433.3, ENST00000352433.4, ENST00000352433.5, ENST00000352433.6, ENST00000352433.7, ENST00000352433.8, ENST00000352433.9, hCG_16307 , NM_004219, PTTG1 , Q6IAL9, Q6IAL9_HUMAN, uc317yga.1, uc317yga.2
UCSC ID: ENST00000352433.10_4
RefSeq Accession: NM_004219.4
Protein: Q6IAL9

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.