ID:PTHY_HUMAN DESCRIPTION: RecName: Full=Parathyroid hormone; Short=PTH; AltName: Full=Parathormone; AltName: Full=Parathyrin; Flags: Precursor; FUNCTION: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. SUBUNIT: Interacts with PTH1R (via N-terminal extracellular domain). SUBCELLULAR LOCATION: Secreted. DISEASE: Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. SIMILARITY: Belongs to the parathyroid hormone family. WEB RESOURCE: Name=Wikipedia; Note=Parathyroid hormone entry; URL="http://en.wikipedia.org/wiki/Parathyroid_hormone";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01270
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001501 skeletal system development GO:0006874 cellular calcium ion homeostasis GO:0007186 G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007266 Rho protein signal transduction GO:0007267 cell-cell signaling GO:0008628 hormone-mediated apoptotic signaling pathway GO:0009967 positive regulation of signal transduction GO:0010288 response to lead ion GO:0010468 regulation of gene expression GO:0010469 regulation of receptor activity GO:0030501 positive regulation of bone mineralization GO:0030819 positive regulation of cAMP biosynthetic process GO:0031667 response to nutrient levels GO:0032331 negative regulation of chondrocyte differentiation GO:0033280 response to vitamin D GO:0034645 cellular macromolecule biosynthetic process GO:0042493 response to drug GO:0045453 bone resorption GO:0045471 response to ethanol GO:0045725 positive regulation of glycogen biosynthetic process GO:0045778 positive regulation of ossification GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046058 cAMP metabolic process GO:0046326 positive regulation of glucose import GO:0046686 response to cadmium ion GO:0048873 homeostasis of number of cells within a tissue GO:0060732 positive regulation of inositol phosphate biosynthetic process GO:0071107 response to parathyroid hormone GO:0071774 response to fibroblast growth factor GO:0071864 positive regulation of cell proliferation in bone marrow GO:0071866 negative regulation of apoptotic process in bone marrow GO:0090290 positive regulation of osteoclast proliferation GO:1900158 negative regulation of bone mineralization involved in bone maturation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
