Human Gene PRMT9 (ENST00000322396.7_7) from GENCODE V47lift37
  Description: protein arginine methyltransferase 9, transcript variant 1 (from RefSeq NM_138364.4)
Gencode Transcript: ENST00000322396.7_7
Gencode Gene: ENSG00000164169.13_11
Transcript (Including UTRs)
   Position: hg19 chr4:148,558,936-148,605,314 Size: 46,379 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr4:148,559,683-148,605,138 Size: 45,456 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:148,558,936-148,605,314)mRNA (may differ from genome)Protein (845 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ANM10_HUMAN
DESCRIPTION: RecName: Full=Putative protein arginine N-methyltransferase 10; EC=2.1.1.-;
SIMILARITY: Belongs to the protein arginine N-methyltransferase family.
SIMILARITY: Contains 3 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.96 RPKM in Testis
Total median expression: 194.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.80176-0.328 Picture PostScript Text
3' UTR -158.40747-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025799 - Arg_MeTrfase
IPR010456 - Ribosomal-L11_MeTrfase_PrmA
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF06325 - Ribosomal protein L11 methyltransferase (PrmA)

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
51735 - NAD(P)-binding Rossmann-fold domains
52833 - Thioredoxin-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q6P2P2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity

Biological Process:
GO:0006397 mRNA processing
GO:0006479 protein methylation
GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0032259 methylation
GO:0035246 peptidyl-arginine N-methylation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC004337 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone IMAGE:3631943), partial cds.
AL137452 - Homo sapiens mRNA; cDNA DKFZp761C029 (from clone DKFZp761C029).
AK292904 - Homo sapiens cDNA FLJ75167 complete cds.
BC021250 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone IMAGE:3347567), partial cds.
BC064403 - Homo sapiens hypothetical protein BC004337, mRNA (cDNA clone MGC:75212 IMAGE:5547611), complete cds.
LF384403 - JP 2014500723-A/191906: Polycomb-Associated Non-Coding RNAs.
AK128483 - Homo sapiens cDNA FLJ46629 fis, clone TRACH2013585.
AK096703 - Homo sapiens cDNA FLJ39384 fis, clone PLACE5000066.
KJ895138 - Synthetic construct Homo sapiens clone ccsbBroadEn_04532 PRMT10 gene, encodes complete protein.
LF373074 - JP 2014500723-A/180577: Polycomb-Associated Non-Coding RNAs.
JD287646 - Sequence 268670 from Patent EP1572962.
JD416478 - Sequence 397502 from Patent EP1572962.
JD112966 - Sequence 93990 from Patent EP1572962.
JD114651 - Sequence 95675 from Patent EP1572962.
JD168868 - Sequence 149892 from Patent EP1572962.
LF373071 - JP 2014500723-A/180574: Polycomb-Associated Non-Coding RNAs.
LF373068 - JP 2014500723-A/180571: Polycomb-Associated Non-Coding RNAs.
JD235407 - Sequence 216431 from Patent EP1572962.
JD275070 - Sequence 256094 from Patent EP1572962.
JD195074 - Sequence 176098 from Patent EP1572962.
JD511149 - Sequence 492173 from Patent EP1572962.
JD535253 - Sequence 516277 from Patent EP1572962.
JD248067 - Sequence 229091 from Patent EP1572962.
LF373062 - JP 2014500723-A/180565: Polycomb-Associated Non-Coding RNAs.
JD278317 - Sequence 259341 from Patent EP1572962.
MA619980 - JP 2018138019-A/191906: Polycomb-Associated Non-Coding RNAs.
MA608651 - JP 2018138019-A/180577: Polycomb-Associated Non-Coding RNAs.
MA608648 - JP 2018138019-A/180574: Polycomb-Associated Non-Coding RNAs.
MA608645 - JP 2018138019-A/180571: Polycomb-Associated Non-Coding RNAs.
MA608639 - JP 2018138019-A/180565: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA39, ANM9_HUMAN, B3KU92, ENST00000322396.1, ENST00000322396.2, ENST00000322396.3, ENST00000322396.4, ENST00000322396.5, ENST00000322396.6, NM_138364, PRMT10, PRMT9 , Q6P2P2, Q6ZR58, Q8N383, Q9BT55, Q9NT98, uc317rgz.1, uc317rgz.2
UCSC ID: ENST00000322396.7_7
RefSeq Accession: NM_138364.4
Protein: Q6P2P2 (aka ANM10_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.