Human Gene PPARGC1A (ENST00000264867.7_7) from GENCODE V47lift37
  Description: PPARG coactivator 1 alpha, transcript variant 15 (from RefSeq NR_148987.2)
Gencode Transcript: ENST00000264867.7_7
Gencode Gene: ENSG00000109819.9_9
Transcript (Including UTRs)
   Position: hg19 chr4:23,793,644-23,891,670 Size: 98,027 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr4:23,797,445-23,891,580 Size: 94,136 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:23,793,644-23,891,670)mRNA (may differ from genome)Protein (798 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PRGC1_HUMAN
DESCRIPTION: RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Short=PGC-1-alpha; Short=PPAR-gamma coactivator 1-alpha; Short=PPARGC-1-alpha; AltName: Full=Ligand effect modulator 6;
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism.
SUBUNIT: Binds MYBBP1A, which inhibits transcriptional activation by this protein (By similarity). Interacts with PRDM16 (By similarity). Interacts with LRPPRC. Homooligomer. Interacts with LPIN1 (By similarity).
INTERACTION: P42704:LRPPRC; NbExp=2; IntAct=EBI-765486, EBI-1050853;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
INDUCTION: Transcription is repressed by ZNF746 which binds to 'insulin response sequences' its promoter.
PTM: Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter (By similarity). Phosphorylated by CLK2 (By similarity).
PTM: Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ppargc1a/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PPARGC1A
Diseases sorted by gene-association score: obesity (9), lipomatosis (6), amyotrophic lateral sclerosis 1* (5), huntington disease (4), diabetes mellitus, noninsulin-dependent (3), leigh syndrome (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.28 RPKM in Heart - Atrial Appendage
Total median expression: 109.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.5090-0.217 Picture PostScript Text
3' UTR -924.603801-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

SCOP Domains:
54928 - RNA-binding domain, RBD

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1XB7 - X-ray MuPIT 3B1M - X-ray MuPIT 3CS8 - X-ray 3D24 - X-ray MuPIT 3U9Q - X-ray MuPIT 3V9T - X-ray MuPIT 3V9V - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9UBK2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043014 alpha-tubulin binding
GO:0043565 sequence-specific DNA binding
GO:0050681 androgen receptor binding
GO:1990841 promoter-specific chromatin binding

Biological Process:
GO:0000302 response to reactive oxygen species
GO:0000422 mitophagy
GO:0001659 temperature homeostasis
GO:0001666 response to hypoxia
GO:0001678 cellular glucose homeostasis
GO:0001933 negative regulation of protein phosphorylation
GO:0002021 response to dietary excess
GO:0002931 response to ischemia
GO:0006012 galactose metabolic process
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0007586 digestion
GO:0007623 circadian rhythm
GO:0008209 androgen metabolic process
GO:0008380 RNA splicing
GO:0009409 response to cold
GO:0009750 response to fructose
GO:0010822 positive regulation of mitochondrion organization
GO:0014070 response to organic cyclic compound
GO:0014732 skeletal muscle atrophy
GO:0014823 response to activity
GO:0014850 response to muscle activity
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014912 negative regulation of smooth muscle cell migration
GO:0019395 fatty acid oxidation
GO:0021549 cerebellum development
GO:0022904 respiratory electron transport chain
GO:0030521 androgen receptor signaling pathway
GO:0030900 forebrain development
GO:0031325 positive regulation of cellular metabolic process
GO:0031667 response to nutrient levels
GO:0032922 circadian regulation of gene expression
GO:0034599 cellular response to oxidative stress
GO:0035066 positive regulation of histone acetylation
GO:0035865 cellular response to potassium ion
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0043201 response to leucine
GO:0043524 negative regulation of neuron apoptotic process
GO:0045333 cellular respiration
GO:0045722 positive regulation of gluconeogenesis
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046321 positive regulation of fatty acid oxidation
GO:0048511 rhythmic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050821 protein stabilization
GO:0050873 brown fat cell differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051552 flavone metabolic process
GO:0051602 response to electrical stimulus
GO:0060612 adipose tissue development
GO:0065003 macromolecular complex assembly
GO:0071222 cellular response to lipopolysaccharide
GO:0071250 cellular response to nitrite
GO:0071313 cellular response to caffeine
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071871 response to epinephrine
GO:0071873 response to norepinephrine
GO:0090258 negative regulation of mitochondrial fission
GO:0097009 energy homeostasis
GO:0097066 response to thyroid hormone
GO:0097067 cellular response to thyroid hormone stimulus
GO:1901215 negative regulation of neuron death
GO:1901558 response to metformin
GO:1901857 positive regulation of cellular respiration
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901863 positive regulation of muscle tissue development
GO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process
GO:1904637 cellular response to ionomycin
GO:1904639 cellular response to resveratrol
GO:1904640 response to methionine
GO:1990845 adaptive thermogenesis
GO:2000184 positive regulation of progesterone biosynthetic process
GO:2000272 negative regulation of receptor activity
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2001171 positive regulation of ATP biosynthetic process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005719 nuclear euchromatin
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016605 PML body
GO:0022626 cytosolic ribosome
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0097440 apical dendrite
GO:1990843 subsarcolemmal mitochondrion
GO:1990844 interfibrillar mitochondrion


-  Descriptions from all associated GenBank mRNAs
  JQ772116 - Homo sapiens peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4 (PPARGC1A) mRNA, complete cds, alternatively spliced.
JQ772117 - Homo sapiens peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5 (PPARGC1A) mRNA, complete cds, alternatively spliced.
JQ772118 - Homo sapiens peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT (PPARGC1A) mRNA, complete cds, alternatively spliced.
JQ772119 - Homo sapiens peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a (PPARGC1A) mRNA, complete cds, alternatively spliced.
JQ772120 - Homo sapiens peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext (PPARGC1A) mRNA, complete cds, alternatively spliced.
AF106698 - Homo sapiens PPAR gamma coactivator-1 (PPARGC1) mRNA, complete cds.
AF186379 - Homo sapiens ligand effect modulator-6 (LEM6) mRNA, complete cds.
HQ695733 - Homo sapiens L-PGC-1alpha (PPARGC1A) mRNA, complete cds.
AB061325 - Homo sapiens PGC-1v mRNA for PPAR gamma coactivator variant form, complete cds.
AF159714 - Homo sapiens PPAR gamma coactivator-1 mRNA, complete cds.
BC157068 - Synthetic construct Homo sapiens clone IMAGE:100063322, MGC:190741 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) mRNA, encodes complete protein.
BC156323 - Synthetic construct Homo sapiens clone IMAGE:100061732, MGC:190086 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) mRNA, encodes complete protein.
AK309261 - Homo sapiens cDNA, FLJ99302.
AK301883 - Homo sapiens cDNA FLJ52961 complete cds, highly similar to Peroxisome proliferator-activated receptorgamma coactivator 1-alpha.
AK296591 - Homo sapiens cDNA FLJ58997 complete cds, highly similar to Peroxisome proliferator-activated receptor gamma coactivator 1-alpha.
AK024990 - Homo sapiens cDNA: FLJ21337 fis, clone COL02556, highly similar to AF106698 Homo sapiens PPAR gamma coactivator-1 (PPARGC1) mRNA.
JD428537 - Sequence 409561 from Patent EP1572962.
JD565967 - Sequence 546991 from Patent EP1572962.
JD039268 - Sequence 20292 from Patent EP1572962.
JD565813 - Sequence 546837 from Patent EP1572962.
JD156041 - Sequence 137065 from Patent EP1572962.
JD174945 - Sequence 155969 from Patent EP1572962.
JD499734 - Sequence 480758 from Patent EP1572962.
JD239032 - Sequence 220056 from Patent EP1572962.
JD548757 - Sequence 529781 from Patent EP1572962.
JD313504 - Sequence 294528 from Patent EP1572962.
JD182129 - Sequence 163153 from Patent EP1572962.
JD236937 - Sequence 217961 from Patent EP1572962.
JD491007 - Sequence 472031 from Patent EP1572962.
JD295267 - Sequence 276291 from Patent EP1572962.
JD262320 - Sequence 243344 from Patent EP1572962.
JD037015 - Sequence 18039 from Patent EP1572962.
JD495404 - Sequence 476428 from Patent EP1572962.
JD168474 - Sequence 149498 from Patent EP1572962.
JD378871 - Sequence 359895 from Patent EP1572962.
JD531233 - Sequence 512257 from Patent EP1572962.
JD146770 - Sequence 127794 from Patent EP1572962.
JD290812 - Sequence 271836 from Patent EP1572962.
JD385996 - Sequence 367020 from Patent EP1572962.
JD185696 - Sequence 166720 from Patent EP1572962.
JD505019 - Sequence 486043 from Patent EP1572962.
JD232143 - Sequence 213167 from Patent EP1572962.
JD381536 - Sequence 362560 from Patent EP1572962.
JD250770 - Sequence 231794 from Patent EP1572962.
JD300159 - Sequence 281183 from Patent EP1572962.
JD133699 - Sequence 114723 from Patent EP1572962.
JD511391 - Sequence 492415 from Patent EP1572962.
JD350735 - Sequence 331759 from Patent EP1572962.
JD042056 - Sequence 23080 from Patent EP1572962.
JD053515 - Sequence 34539 from Patent EP1572962.
JD053514 - Sequence 34538 from Patent EP1572962.
JD040704 - Sequence 21728 from Patent EP1572962.
JD303720 - Sequence 284744 from Patent EP1572962.
JD039275 - Sequence 20299 from Patent EP1572962.
JD503324 - Sequence 484348 from Patent EP1572962.
JD410417 - Sequence 391441 from Patent EP1572962.
JD307686 - Sequence 288710 from Patent EP1572962.
JD316036 - Sequence 297060 from Patent EP1572962.
JD301858 - Sequence 282882 from Patent EP1572962.
JD037657 - Sequence 18681 from Patent EP1572962.
JD233116 - Sequence 214140 from Patent EP1572962.
JD090692 - Sequence 71716 from Patent EP1572962.
JD355293 - Sequence 336317 from Patent EP1572962.
JD063288 - Sequence 44312 from Patent EP1572962.
JD198941 - Sequence 179965 from Patent EP1572962.
JD112924 - Sequence 93948 from Patent EP1572962.
BC029800 - Homo sapiens peroxisome proliferator-activated receptor gamma, coactivator 1 alpha, mRNA (cDNA clone IMAGE:5187727), with apparent retained intron.
JD134845 - Sequence 115869 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ppargPathway - Role of PPAR-gamma Coactivators in Obesity and Thermogenesis
h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor
h_pgc1aPathway - Regulation of PGC-1a
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

Reactome (by CSHL, EBI, and GO)

Protein Q9UBK2 (Reactome details) participates in the following event(s):

R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands
R-HSA-1368087 RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene
R-HSA-1592233 p38 MAPK phosphorylates PPARGC1A
R-HSA-1592244 AMPK phosphorylates PPARGC1A
R-HSA-5663273 RORA, EP300, PPARGC1A bind NR1D1 gene
R-HSA-8939929 ESRRA:PPARG1CA binds the RUNX2 gene promoter
R-HSA-1592236 NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter
R-HSA-2466391 NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter
R-HSA-2466392 NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400253 Circadian Clock
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-1266738 Developmental Biology
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B7Z406, ENST00000264867.1, ENST00000264867.2, ENST00000264867.3, ENST00000264867.4, ENST00000264867.5, ENST00000264867.6, G8DM16, I3RTT5, I3RTT6, I3RTT7, I3RTT8, I3RTT9, LEM6, NR_148987, PGC1, PGC1A , PPARGC1, PRGC1_HUMAN, Q3LIG1, Q4W5M7, Q9UBK2, Q9UN32, uc317hwf.1, uc317hwf.2
UCSC ID: ENST00000264867.7_7
RefSeq Accession: NM_013261.5
Protein: Q9UBK2 (aka PRGC1_HUMAN or PPG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.