Human Gene PPARG (ENST00000651735.1_10) from GENCODE V47lift37
  Description: peroxisome proliferator activated receptor gamma, transcript variant 3 (from RefSeq NM_138711.6)
Gencode Transcript: ENST00000651735.1_10
Gencode Gene: ENSG00000132170.24_19
Transcript (Including UTRs)
   Position: hg19 chr3:12,330,569-12,475,843 Size: 145,275 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr3:12,421,211-12,475,644 Size: 54,434 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:12,330,569-12,475,843)mRNA (may differ from genome)Protein (475 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: E9PFV2_HUMAN
DESCRIPTION: SubName: Full=Peroxisome proliferator-activated receptor gamma;
SIMILARITY: Belongs to the nuclear hormone receptor family.
SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PPARG
Diseases sorted by gene-association score: lipodystrophy, familial partial, type 3* (1650), carotid intimal medial thickness 1* (500), diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension* (500), obesity* (439), morbid obesity* (413), differentiated thyroid carcinoma* (132), diabetes mellitus, noninsulin-dependent* (128), obesity, pparg-related* (100), colonic benign neoplasm* (87), colorectal cancer* (76), cardiovascular disease risk factor )* (71), atherosclerosis (24), lipodystrophy (22), familial partial lipodystrophy (20), idiopathic edema (13), thyroid cancer (13), autoimmune myocarditis (13), acdc (12), neonatal meningitis (12), alcoholic cardiomyopathy (12), salivary gland cancer (12), liposarcoma (11), thyroid cancer, nonmedullary, 2 (10), congenital cytomegalovirus (10), prediabetes syndrome (10), nelson syndrome (9), hyperglycemia (9), lipid metabolism disorder (8), giant cell glioblastoma* (8), monocytic leukemia (7), bowenoid papulosis (7), arteriosclerosis (7), nonalcoholic steatohepatitis (7), acquired metabolic disease (7), skin carcinoma in situ (7), gliosarcoma* (7), lichen planopilaris (6), abdominal obesity-metabolic syndrome 1 (6), glucose metabolism disease (6), overnutrition (6), prostate disease (6), thyroid cancer, nonmedullary, 1 (6), 3-hydroxyacyl-coa dehydrogenase deficiency (5), corticosteroid-binding globulin deficiency (5), arrhythmogenic right ventricular dysplasia 5 (4), glioblastoma multiforme (4), vascular disease (3), lung cancer (3), autoinflammation, lipodystrophy, and dermatosis syndrome (2), diabetes mellitus, insulin-dependent (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.80147-0.148 Picture PostScript Text
3' UTR -24.10199-0.121 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003074 - 1Cnucl_rcpt
IPR003077 - 1Cnucl_rcpt_G
IPR008946 - Nucl_hormone_rcpt_ligand-bd
IPR000536 - Nucl_hrmn_rcpt_lig-bd_core
IPR022590 - PPARgamma_N
IPR001723 - Str_hrmn_rcpt
IPR001628 - Znf_hrmn_rcpt
IPR013088 - Znf_NHR/GATA

Pfam Domains:
PF00104 - Ligand-binding domain of nuclear hormone receptor
PF00105 - Zinc finger, C4 type (two domains)
PF12577 - PPAR gamma N-terminal region

SCOP Domains:
48508 - Nuclear receptor ligand-binding domain
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on E9PFV2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030522 intracellular receptor signaling pathway
GO:0043401 steroid hormone mediated signaling pathway
GO:0048511 rhythmic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AB565476 - Homo sapiens PPAR gamma mRNA for peroxisome proliferative activated receptor gamma, complete cds.
LP895444 - Sequence 308 from Patent EP3253886.
X90563 - H.sapiens mRNA for peroxisome proliferactor activated receptor gamma.
AK290581 - Homo sapiens cDNA FLJ75648 complete cds, highly similar to Homo sapiens peroxisome proliferative activated receptor, gamma(PPARG), transcript variant 4, mRNA.
L40904 - Homo sapiens peroxisome proliferator activated receptor gamma (PPARG) mRNA, complete cds.
AB472042 - Homo sapiens PPARG mRNA for peroxisome proliferative activated receptor gamma isoform 6 variant, complete cds.
BC006811 - Homo sapiens peroxisome proliferator-activated receptor gamma, mRNA (cDNA clone MGC:5041 IMAGE:3447380), complete cds.
AJ698135 - Homo sapiens mRNA for peroxisome proliferative activated receptor gamma (PPARG gene), exon 5 skipping transcript.
D83233 - Homo sapiens mRNA for PPAR gamma2, complete cds.
U79012 - Human ligand activated transcription factor PPARgamma2 mRNA, complete cds.
AB451486 - Homo sapiens PPARG mRNA for peroxisome proliferative activated receptor gamma isoform 2, partial cds, clone: FLJ82517SAAF.
AB451337 - Homo sapiens PPARG mRNA for peroxisome proliferative activated receptor gamma isoform 2, complete cds, clone: FLJ82517SAAN.
U63415 - Human peroxisome proliferator activated receptor gamma 2 mRNA, complete cds.
AK223528 - Homo sapiens mRNA for peroxisome proliferative activated receptor gamma isoform 2 variant, clone: FCC124E05.
AY222643 - Homo sapiens CREB3L2-PPARgamma mRNA, complete cds.
CU675463 - Synthetic construct Homo sapiens gateway clone IMAGE:100019580 5' read PPARG mRNA.
DQ356894 - Homo sapiens peroxisome proliferative acitvated receptor gamma (PPARG) mRNA, complete cds, alternatively spliced.
AB528351 - Synthetic construct DNA, clone: pF1KB7770, Homo sapiens PPARG gene for peroxisome proliferator-activated receptor gamma, without stop codon, in Flexi system.
KU178267 - Homo sapiens peroxisome proliferator-activated receptor gamma isoform 1 (PPARG) mRNA, partial cds.
KU178268 - Homo sapiens peroxisome proliferator-activated receptor gamma isoform 2 (PPARG) mRNA, partial cds, alternatively spliced.
KJ891855 - Synthetic construct Homo sapiens clone ccsbBroadEn_01249 PPARG gene, encodes complete protein.
KR709631 - Synthetic construct Homo sapiens clone CCSBHm_00004352 PPARG (PPARG) mRNA, encodes complete protein.
KR709632 - Synthetic construct Homo sapiens clone CCSBHm_00004356 PPARG (PPARG) mRNA, encodes complete protein.
KR709633 - Synthetic construct Homo sapiens clone CCSBHm_00004358 PPARG (PPARG) mRNA, encodes complete protein.
KR709634 - Synthetic construct Homo sapiens clone CCSBHm_00004362 PPARG (PPARG) mRNA, encodes complete protein.
AB307692 - Homo sapiens NR1C3 mRNA for peroxisome proliferator activated receptor gamma, complete cds.
BT007281 - Homo sapiens peroxisome proliferative activated receptor, gamma mRNA, complete cds.
DQ891108 - Synthetic construct clone IMAGE:100003738; FLH169397.01X; RZPDo839B1196D peroxisome proliferative activated receptor, gamma (PPARG) gene, encodes complete protein.
DQ894289 - Synthetic construct Homo sapiens clone IMAGE:100008749; FLH169393.01L; RZPDo839B1195D peroxisome proliferative activated receptor, gamma (PPARG) gene, encodes complete protein.
HQ692866 - Homo sapiens peroxisome proliferator-activated nuclear receptor gamma variant 1 (NR1C3) mRNA, complete cds.
LS999978 - Homo sapiens partial mRNA for peroxisome proliferator-activated receptor gamma (PPARG1D5 gene).
LS999980 - Homo sapiens partial mRNA for peroxisome proliferator-activated receptor gamma (PPARG3D5 gene).
LS999979 - Homo sapiens partial mRNA for peroxisome proliferator-activated receptor gamma (PPARG2D5 gene).
AB247365 - Homo sapiens PPARG5 mRNA for peroxisome proliferator-activated receptor-gamma 5, complete cds, tissue_type:adipose tissue.
AB247366 - Homo sapiens PPARG mRNA for peroxisome proliferator-activated receptor-gamma splicing variant, complete cds, tissue_type:adipose tissue.
AB247367 - Homo sapiens PPARG5 mRNA for peroxisome proliferator-activated receptor-gamma 5, complete cds, tissue_type:liver.
AB097931 - Homo sapiens PPARG mRNA for peroxisome proliferator-activated receptor gamma 1, partial cds.
AB107271 - Homo sapiens PPARG mRNA for peroxisome proliferator-activated receptor, partial cds.
AJ563370 - Homo sapiens mRNA for peroxisome proliferative activated receptor gamma (PPARG gene), alternative transcript 3.
AJ563369 - Homo sapiens partial mRNA for peroxisome proliferative activated receptor gamma (PPARG gene), alternative transcript 2.
JD134108 - Sequence 115132 from Patent EP1572962.
JD402843 - Sequence 383867 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_pparPathway - Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression
h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity
h_vobesityPathway - Visceral Fat Deposits and the Metabolic Syndrome
h_ppargPathway - Role of PPAR-gamma Coactivators in Obesity and Thermogenesis

-  Other Names for This Gene
  Alternate Gene Symbols: E9PFV2, E9PFV2_HUMAN, NM_138711, PPARG , PPARG5 , uc328tjb.1, uc328tjb.2
UCSC ID: ENST00000651735.1_10
RefSeq Accession: NM_138711.6
Protein: E9PFV2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.