Human Gene PLEKHG1 (ENST00000696526.1_3) from GENCODE V47lift37
  Description: pleckstrin homology and RhoGEF domain containing G1, transcript variant 9 (from RefSeq NM_001329805.2)
Gencode Transcript: ENST00000696526.1_3
Gencode Gene: ENSG00000120278.17_15
Transcript (Including UTRs)
   Position: hg19 chr6:150,921,021-151,164,801 Size: 243,781 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr6:151,054,818-151,162,032 Size: 107,215 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:150,921,021-151,164,801)mRNA (may differ from genome)Protein (1385 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PKHG1_HUMAN
DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family G member 1;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 1 DH (DBL-homology) domain.
SIMILARITY: Contains 1 PH domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.60290-0.347 Picture PostScript Text
3' UTR -670.202769-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000219 - DH-domain
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00621 - RhoGEF domain

SCOP Domains:
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
56672 - DNA/RNA polymerases

ModBase Predicted Comparative 3D Structure on Q9ULL1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity

Biological Process:
GO:0035023 regulation of Rho protein signal transduction

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  AK293288 - Homo sapiens cDNA FLJ61588 partial cds, highly similar to Pleckstrin homology domain-containing family G member 1.
AK307631 - Homo sapiens cDNA, FLJ97579.
AB384583 - Synthetic construct DNA, clone: pF1KA1209, Homo sapiens PLEKHG1 gene for pleckstrin homology domain-containing protein, family G member 1, complete cds, without stop codon, in Flexi system.
AK294798 - Homo sapiens cDNA FLJ52092 complete cds, highly similar to Pleckstrin homology domain-containing family G member 1.
AK056300 - Homo sapiens cDNA FLJ31738 fis, clone NT2RI2007096, highly similar to Pleckstrin homology domain-containing family G member 1.
BC140864 - Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 1, mRNA (cDNA clone MGC:176541 IMAGE:9021732), complete cds.
BC151134 - Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 1, mRNA (cDNA clone MGC:184046 IMAGE:9057034), complete cds.
AJ420468 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2072853.
BC089428 - Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 1, mRNA (cDNA clone IMAGE:3066302), partial cds.
AB033035 - Homo sapiens mRNA for KIAA1209 protein, partial cds.
JD192254 - Sequence 173278 from Patent EP1572962.
JD430650 - Sequence 411674 from Patent EP1572962.
JD279894 - Sequence 260918 from Patent EP1572962.
JD250020 - Sequence 231044 from Patent EP1572962.
JD551633 - Sequence 532657 from Patent EP1572962.
JD455835 - Sequence 436859 from Patent EP1572962.
JD457656 - Sequence 438680 from Patent EP1572962.
JD044665 - Sequence 25689 from Patent EP1572962.
JD160189 - Sequence 141213 from Patent EP1572962.
JD279977 - Sequence 261001 from Patent EP1572962.
JD403635 - Sequence 384659 from Patent EP1572962.
JD136371 - Sequence 117395 from Patent EP1572962.
JD428918 - Sequence 409942 from Patent EP1572962.
JD336681 - Sequence 317705 from Patent EP1572962.
JD380416 - Sequence 361440 from Patent EP1572962.
JD202983 - Sequence 184007 from Patent EP1572962.
JD167901 - Sequence 148925 from Patent EP1572962.
JD333938 - Sequence 314962 from Patent EP1572962.
JD556732 - Sequence 537756 from Patent EP1572962.
JD330200 - Sequence 311224 from Patent EP1572962.
JD416844 - Sequence 397868 from Patent EP1572962.
JD519963 - Sequence 500987 from Patent EP1572962.
JD393801 - Sequence 374825 from Patent EP1572962.
JD428243 - Sequence 409267 from Patent EP1572962.
JD428246 - Sequence 409270 from Patent EP1572962.
JD428244 - Sequence 409268 from Patent EP1572962.
JD428245 - Sequence 409269 from Patent EP1572962.
JD550243 - Sequence 531267 from Patent EP1572962.
JD550244 - Sequence 531268 from Patent EP1572962.
JD550245 - Sequence 531269 from Patent EP1572962.
JD234072 - Sequence 215096 from Patent EP1572962.
JD518156 - Sequence 499180 from Patent EP1572962.
JD151017 - Sequence 132041 from Patent EP1572962.
JD255186 - Sequence 236210 from Patent EP1572962.
JD070798 - Sequence 51822 from Patent EP1572962.
JD364160 - Sequence 345184 from Patent EP1572962.
JD242952 - Sequence 223976 from Patent EP1572962.
JD267515 - Sequence 248539 from Patent EP1572962.
JD188447 - Sequence 169471 from Patent EP1572962.
JD051153 - Sequence 32177 from Patent EP1572962.
JD225066 - Sequence 206090 from Patent EP1572962.
JD455204 - Sequence 436228 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1209, NM_001329805, PKHG1_HUMAN, Q5T1F2, Q9ULL1, uc331bbq.1, uc331bbq.2
UCSC ID: ENST00000696526.1_3
RefSeq Accession: NM_001029884.3
Protein: Q9ULL1 (aka PKHG1_HUMAN or PHG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.