Human Gene PLEKHA7 (ENST00000531066.6_13) from GENCODE V47lift37
  Description: pleckstrin homology domain containing A7, transcript variant 1 (from RefSeq NM_001329630.2)
Gencode Transcript: ENST00000531066.6_13
Gencode Gene: ENSG00000166689.18_20
Transcript (Including UTRs)
   Position: hg19 chr11:16,798,844-17,035,961 Size: 237,118 Total Exon Count: 27 Strand: -
Coding Region
   Position: hg19 chr11:16,800,545-17,035,948 Size: 235,404 Coding Exon Count: 27 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:16,798,844-17,035,961)mRNA (may differ from genome)Protein (1271 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: E9PKC0_HUMAN
DESCRIPTION: SubName: Full=Pleckstrin homology domain-containing family A member 7;
SIMILARITY: Contains 1 PH domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.25 RPKM in Esophagus - Mucosa
Total median expression: 192.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -555.901701-0.327 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR001202 - WW_Rsp5_WWP

Pfam Domains:
PF00169 - PH domain
PF15413 - Pleckstrin homology domain

SCOP Domains:
103657 - BAR/IMD domain-like
50729 - PH domain-like
51045 - WW domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on E9PKC0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  LF207865 - JP 2014500723-A/15368: Polycomb-Associated Non-Coding RNAs.
AB385210 - Synthetic construct DNA, clone: pF1KB9403, Homo sapiens PLEKHA7 gene for pleckstrin homology domain-containing protein, family A member 7, complete cds, without stop codon, in Flexi system.
BC071599 - Homo sapiens pleckstrin homology domain containing, family A member 7, mRNA (cDNA clone MGC:87540 IMAGE:30343461), complete cds.
MA443442 - JP 2018138019-A/15368: Polycomb-Associated Non-Coding RNAs.
BC032761 - Homo sapiens, clone IMAGE:3454274, mRNA.
AL833334 - Homo sapiens mRNA; cDNA DKFZp686B1134 (from clone DKFZp686B1134).
AL833346 - Homo sapiens mRNA; cDNA DKFZp686M2234 (from clone DKFZp686M2234).
JD245539 - Sequence 226563 from Patent EP1572962.
JD272490 - Sequence 253514 from Patent EP1572962.
LF369591 - JP 2014500723-A/177094: Polycomb-Associated Non-Coding RNAs.
JD347543 - Sequence 328567 from Patent EP1572962.
JD515532 - Sequence 496556 from Patent EP1572962.
JD495348 - Sequence 476372 from Patent EP1572962.
JD104931 - Sequence 85955 from Patent EP1572962.
JD504997 - Sequence 486021 from Patent EP1572962.
JD347714 - Sequence 328738 from Patent EP1572962.
JD312511 - Sequence 293535 from Patent EP1572962.
JD085766 - Sequence 66790 from Patent EP1572962.
JD069098 - Sequence 50122 from Patent EP1572962.
JD248628 - Sequence 229652 from Patent EP1572962.
JD345435 - Sequence 326459 from Patent EP1572962.
JD274871 - Sequence 255895 from Patent EP1572962.
JD306947 - Sequence 287971 from Patent EP1572962.
JD480921 - Sequence 461945 from Patent EP1572962.
JD420452 - Sequence 401476 from Patent EP1572962.
JD133907 - Sequence 114931 from Patent EP1572962.
JD440453 - Sequence 421477 from Patent EP1572962.
JD149138 - Sequence 130162 from Patent EP1572962.
JD345417 - Sequence 326441 from Patent EP1572962.
JD204409 - Sequence 185433 from Patent EP1572962.
JD504938 - Sequence 485962 from Patent EP1572962.
JD411338 - Sequence 392362 from Patent EP1572962.
JD060160 - Sequence 41184 from Patent EP1572962.
JD137913 - Sequence 118937 from Patent EP1572962.
JD056091 - Sequence 37115 from Patent EP1572962.
JD385249 - Sequence 366273 from Patent EP1572962.
JD495629 - Sequence 476653 from Patent EP1572962.
BX648885 - Homo sapiens mRNA; cDNA DKFZp686M22243 (from clone DKFZp686M22243).
BC041452 - Homo sapiens pleckstrin homology domain containing, family A member 7, mRNA (cDNA clone IMAGE:5173787), partial cds.
BC033239 - Homo sapiens pleckstrin homology domain containing, family A member 7, mRNA (cDNA clone MGC:45924 IMAGE:5429651), complete cds.
AK301465 - Homo sapiens cDNA FLJ54484 complete cds, highly similar to Homo sapiens pleckstrin homology domain containing, family A member 7 (PLEKHA7), mRNA.
AK296371 - Homo sapiens cDNA FLJ54499 complete cds, highly similar to Homo sapiens pleckstrin homology domain containing, family A member 7 (PLEKHA7), mRNA.
KJ904997 - Synthetic construct Homo sapiens clone ccsbBroadEn_14391 PLEKHA7 gene, encodes complete protein.
JD024890 - Sequence 5914 from Patent EP1572962.
JD029937 - Sequence 10961 from Patent EP1572962.
LF369601 - JP 2014500723-A/177104: Polycomb-Associated Non-Coding RNAs.
LF369603 - JP 2014500723-A/177106: Polycomb-Associated Non-Coding RNAs.
LF369604 - JP 2014500723-A/177107: Polycomb-Associated Non-Coding RNAs.
JD162543 - Sequence 143567 from Patent EP1572962.
JD354527 - Sequence 335551 from Patent EP1572962.
JD076687 - Sequence 57711 from Patent EP1572962.
JD068974 - Sequence 49998 from Patent EP1572962.
LF369612 - JP 2014500723-A/177115: Polycomb-Associated Non-Coding RNAs.
LF369615 - JP 2014500723-A/177118: Polycomb-Associated Non-Coding RNAs.
MA605168 - JP 2018138019-A/177094: Polycomb-Associated Non-Coding RNAs.
MA605178 - JP 2018138019-A/177104: Polycomb-Associated Non-Coding RNAs.
MA605180 - JP 2018138019-A/177106: Polycomb-Associated Non-Coding RNAs.
MA605181 - JP 2018138019-A/177107: Polycomb-Associated Non-Coding RNAs.
MA605189 - JP 2018138019-A/177115: Polycomb-Associated Non-Coding RNAs.
MA605192 - JP 2018138019-A/177118: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PKC0, E9PKC0_HUMAN, ENST00000531066.1, ENST00000531066.2, ENST00000531066.3, ENST00000531066.4, ENST00000531066.5, NM_001329630, PLEKHA7 , uc324iha.1, uc324iha.2
UCSC ID: ENST00000531066.6_13
RefSeq Accession: NM_001329630.2
Protein: E9PKC0

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.