ID:PLD1_HUMAN DESCRIPTION: RecName: Full=Phospholipase D1; Short=PLD 1; Short=hPLD1; EC=3.1.4.4; AltName: Full=Choline phosphatase 1; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D1; FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). CATALYTIC ACTIVITY: A phosphatidylcholine + H(2)O = choline + a phosphatidate. ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate. SUBUNIT: Interacts with PIP5K1B. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side (By similarity). Late endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). TISSUE SPECIFICITY: Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. SIMILARITY: Belongs to the phospholipase D family. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 2 PLD phosphodiesterase domains. SIMILARITY: Contains 1 PX (phox homology) domain. WEB RESOURCE: Name=Wikipedia; Note=Phospholipase D entry; URL="http://en.wikipedia.org/wiki/Phospholipase_D";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13393
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
