Human Gene PIP4K2B (ENST00000619039.5_7) from GENCODE V47lift37
Description: phosphatidylinositol-5-phosphate 4-kinase type 2 beta (from RefSeq NM_003559.5)
Gencode Transcript: ENST00000619039.5_7
Gencode Gene: ENSG00000276293.5_12
Transcript (Including UTRs)
Position: hg19 chr17:36,921,944-36,955,809 Size: 33,866 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr17:36,925,944-36,955,677 Size: 29,734 Coding Exon Count: 10
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PI42B_HUMAN
DESCRIPTION: RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; EC=2.7.1.149; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; AltName: Full=Diphosphoinositide kinase 2-beta; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II beta; Short=PI(5)P 4-kinase type II beta; Short=PIP4KII-beta; AltName: Full=PtdIns(5)P-4-kinase isoform 2-beta;
FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate; Vmax=0.2 pmol/min/ug enzyme;SUBUNIT: Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum (By similarity).TISSUE SPECIFICITY: Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.PTM: Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.SIMILARITY: Contains 1 PIPK domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR023610 - PInositol-4-P-5-kinase
IPR002498 - PInositol-4-P-5-kinase_core
IPR016034 - PInositol-4P-5-kinase_core_sub
Pfam Domains: PF01504 - Phosphatidylinositol-4-phosphate 5-Kinase
SCOP Domains: 56104 - SAICAR synthase-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P78356
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC073896 - Homo sapiens cDNA clone IMAGE:4158112, partial cds.BC094858 - Homo sapiens cDNA clone IMAGE:3535440.DQ572189 - Homo sapiens piRNA piR-40301, complete sequence.JD112951 - Sequence 93975 from Patent EP1572962.JD156696 - Sequence 137720 from Patent EP1572962.JD260794 - Sequence 241818 from Patent EP1572962.U85245 - Human phosphatidylinositol-4-phosphate 5-kinase type II beta mRNA, complete cds.JD041705 - Sequence 22729 from Patent EP1572962.JD486606 - Sequence 467630 from Patent EP1572962.JD210205 - Sequence 191229 from Patent EP1572962.JD303779 - Sequence 284803 from Patent EP1572962.JD074733 - Sequence 55757 from Patent EP1572962.JD436398 - Sequence 417422 from Patent EP1572962.JD540055 - Sequence 521079 from Patent EP1572962.JD063326 - Sequence 44350 from Patent EP1572962.JD512989 - Sequence 494013 from Patent EP1572962.AK307169 - Homo sapiens cDNA, FLJ97117.JD073573 - Sequence 54597 from Patent EP1572962.JD400980 - Sequence 382004 from Patent EP1572962.JD389411 - Sequence 370435 from Patent EP1572962.JD555760 - Sequence 536784 from Patent EP1572962.JD484170 - Sequence 465194 from Patent EP1572962.JD318284 - Sequence 299308 from Patent EP1572962.JD102533 - Sequence 83557 from Patent EP1572962.JD555757 - Sequence 536781 from Patent EP1572962.JD480833 - Sequence 461857 from Patent EP1572962.JD124170 - Sequence 105194 from Patent EP1572962.JD540426 - Sequence 521450 from Patent EP1572962.JD339679 - Sequence 320703 from Patent EP1572962.JD176021 - Sequence 157045 from Patent EP1572962.JD417349 - Sequence 398373 from Patent EP1572962.JD551801 - Sequence 532825 from Patent EP1572962.JD415591 - Sequence 396615 from Patent EP1572962.JD399188 - Sequence 380212 from Patent EP1572962.JD475906 - Sequence 456930 from Patent EP1572962.JD383971 - Sequence 364995 from Patent EP1572962.JD335692 - Sequence 316716 from Patent EP1572962.JD288377 - Sequence 269401 from Patent EP1572962.JD555494 - Sequence 536518 from Patent EP1572962.JD095794 - Sequence 76818 from Patent EP1572962.JD516507 - Sequence 497531 from Patent EP1572962.JD093016 - Sequence 74040 from Patent EP1572962.JD180409 - Sequence 161433 from Patent EP1572962.JD399234 - Sequence 380258 from Patent EP1572962.JD055530 - Sequence 36554 from Patent EP1572962.JD104963 - Sequence 85987 from Patent EP1572962.JD513849 - Sequence 494873 from Patent EP1572962.JD045708 - Sequence 26732 from Patent EP1572962.JD090483 - Sequence 71507 from Patent EP1572962.JD207447 - Sequence 188471 from Patent EP1572962.JD327462 - Sequence 308486 from Patent EP1572962.JD077016 - Sequence 58040 from Patent EP1572962.JD162915 - Sequence 143939 from Patent EP1572962.JD411705 - Sequence 392729 from Patent EP1572962.BT019614 - Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type II, beta mRNA, complete cds.AB529089 - Synthetic construct DNA, clone: pF1KB4223, Homo sapiens PIP5K2B gene for phosphatidylinositol-5-phosphate 4-kinase, type II, beta, without stop codon, in Flexi system.BC027459 - Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, beta, mRNA (cDNA clone MGC:34571 IMAGE:3877995), complete cds.CU693266 - Synthetic construct Homo sapiens gateway clone IMAGE:100016636 5' read PIP4K2B mRNA.KJ901876 - Synthetic construct Homo sapiens clone ccsbBroadEn_11270 PIP4K2B gene, encodes complete protein.JD133542 - Sequence 114566 from Patent EP1572962.JD395988 - Sequence 377012 from Patent EP1572962.JD542060 - Sequence 523084 from Patent EP1572962.JD473134 - Sequence 454158 from Patent EP1572962.JD408880 - Sequence 389904 from Patent EP1572962.JD395968 - Sequence 376992 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000619039.1, ENST00000619039.2, ENST00000619039.3, ENST00000619039.4, NM_003559, P78356, PI42B_HUMAN, PIP4K2B , PIP5K2B, Q5U0E8, Q8TBP2, uc327sch.1, uc327sch.2UCSC ID: ENST00000619039.5_7RefSeq Accession: NM_003559.5
Protein: P78356
(aka PI42B_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.