Human Gene PGRMC1 (ENST00000217971.8_4) from GENCODE V47lift37
  Description: progesterone receptor membrane component 1, transcript variant 1 (from RefSeq NM_006667.5)
Gencode Transcript: ENST00000217971.8_4
Gencode Gene: ENSG00000101856.10_7
Transcript (Including UTRs)
   Position: hg19 chrX:118,370,248-118,378,429 Size: 8,182 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chrX:118,370,327-118,377,217 Size: 6,891 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:118,370,248-118,378,429)mRNA (may differ from genome)Protein (195 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PGRMC1
Diseases sorted by gene-association score: supraglottis cancer (19), patulous eustachian tube (17), eustachian tube disease (17), herpetic whitlow (16), trachea adenoid cystic carcinoma (16), petrous apex meningioma (16), cerebral falx meningioma (15), olfactory groove meningioma (15), anterior cranial fossa meningioma (15), tracheal cancer (14), bladder calculus (10), uterine sarcoma (9), dysbaric osteonecrosis (9), non-suppurative otitis media (8), preterm premature rupture of the membranes (7), tracheal disease (7), parotid disease (7), klatskin's tumor (7), discrete subaortic stenosis (7), tracheal stenosis (6), sphenoid sinusitis (6), spondylolysis (6), chronic dacryocystitis (6), chronic inflammation of lacrimal passage (6), lacrimal duct obstruction (5), trigeminal nerve disease (5), cecal disease (5), spondylolisthesis (5), lower urinary tract calculus (5), salivary gland disease (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 133.53 RPKM in Adrenal Gland
Total median expression: 3102.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.6079-0.248 Picture PostScript Text
3' UTR -282.001212-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001199 - Cyt_B5

Pfam Domains:
PF00173 - Cytochrome b5-like Heme/Steroid binding domain

SCOP Domains:
55856 - Cytochrome b5-like heme/steroid binding domain

ModBase Predicted Comparative 3D Structure on Q6IB11
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  DQ894958 - Synthetic construct Homo sapiens clone IMAGE:100009418; FLH179805.01L; RZPDo839C12131D progesterone receptor membrane component 1 (PGRMC1) gene, encodes complete protein.
LF211449 - JP 2014500723-A/18952: Polycomb-Associated Non-Coding RNAs.
AK313956 - Homo sapiens cDNA, FLJ94602, Homo sapiens progesterone receptor membrane component 1 (PGRMC1),mRNA.
JD408755 - Sequence 389779 from Patent EP1572962.
Y12711 - Homo sapiens mRNA for putative progesterone binding protein.
BC034238 - Homo sapiens progesterone receptor membrane component 1, mRNA (cDNA clone MGC:8891 IMAGE:3863377), complete cds.
AK293618 - Homo sapiens cDNA FLJ50115 complete cds, moderately similar to Membrane-associated progesterone receptor component 1.
JD130663 - Sequence 111687 from Patent EP1572962.
DQ891774 - Synthetic construct clone IMAGE:100004404; FLH179809.01X; RZPDo839C12132D progesterone receptor membrane component 1 (PGRMC1) gene, encodes complete protein.
KJ904663 - Synthetic construct Homo sapiens clone ccsbBroadEn_14057 PGRMC1-like gene, encodes complete protein.
CR456993 - Homo sapiens full open reading frame cDNA clone RZPDo834E065D for gene PGRMC1, progesterone receptor membrane component 1; complete cds, incl. stopcodon.
LF379778 - JP 2014500723-A/187281: Polycomb-Associated Non-Coding RNAs.
LF379780 - JP 2014500723-A/187283: Polycomb-Associated Non-Coding RNAs.
LF379781 - JP 2014500723-A/187284: Polycomb-Associated Non-Coding RNAs.
LF379791 - JP 2014500723-A/187294: Polycomb-Associated Non-Coding RNAs.
LF379793 - JP 2014500723-A/187296: Polycomb-Associated Non-Coding RNAs.
LF379801 - JP 2014500723-A/187304: Polycomb-Associated Non-Coding RNAs.
JD091261 - Sequence 72285 from Patent EP1572962.
LF379802 - JP 2014500723-A/187305: Polycomb-Associated Non-Coding RNAs.
LF379803 - JP 2014500723-A/187306: Polycomb-Associated Non-Coding RNAs.
JD156592 - Sequence 137616 from Patent EP1572962.
JD233773 - Sequence 214797 from Patent EP1572962.
JD298611 - Sequence 279635 from Patent EP1572962.
JD131436 - Sequence 112460 from Patent EP1572962.
JD348863 - Sequence 329887 from Patent EP1572962.
JD063782 - Sequence 44806 from Patent EP1572962.
JD036551 - Sequence 17575 from Patent EP1572962.
JD102874 - Sequence 83898 from Patent EP1572962.
JD130084 - Sequence 111108 from Patent EP1572962.
JD239026 - Sequence 220050 from Patent EP1572962.
JD410708 - Sequence 391732 from Patent EP1572962.
LF379804 - JP 2014500723-A/187307: Polycomb-Associated Non-Coding RNAs.
MA447026 - JP 2018138019-A/18952: Polycomb-Associated Non-Coding RNAs.
MA615355 - JP 2018138019-A/187281: Polycomb-Associated Non-Coding RNAs.
MA615357 - JP 2018138019-A/187283: Polycomb-Associated Non-Coding RNAs.
MA615358 - JP 2018138019-A/187284: Polycomb-Associated Non-Coding RNAs.
MA615368 - JP 2018138019-A/187294: Polycomb-Associated Non-Coding RNAs.
MA615370 - JP 2018138019-A/187296: Polycomb-Associated Non-Coding RNAs.
MA615378 - JP 2018138019-A/187304: Polycomb-Associated Non-Coding RNAs.
MA615379 - JP 2018138019-A/187305: Polycomb-Associated Non-Coding RNAs.
MA615380 - JP 2018138019-A/187306: Polycomb-Associated Non-Coding RNAs.
MA615381 - JP 2018138019-A/187307: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000217971.1, ENST00000217971.2, ENST00000217971.3, ENST00000217971.4, ENST00000217971.5, ENST00000217971.6, ENST00000217971.7, hCG_23188 , NM_006667, PGRMC1 , Q6IB11, Q6IB11_HUMAN, uc317cuq.1, uc317cuq.2
UCSC ID: ENST00000217971.8_4
RefSeq Accession: NM_006667.5
Protein: Q6IB11

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.