ID:PARP9_HUMAN DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 9; Short=PARP-9; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 9; Short=ARTD9; AltName: Full=B aggressive lymphoma protein; FUNCTION: Involved in inducing the expression of IFN-gamma- responsive genes. CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. SUBUNIT: Interacts with DTX3L. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. TISSUE SPECIFICITY: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells. INDUCTION: Up-regulated by IFN-gamma in B-cell lymphoma cell lines. DISEASE: Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors. SIMILARITY: Contains 2 Macro domains. SIMILARITY: Contains 1 PARP catalytic domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IXQ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003950 NAD+ ADP-ribosyltransferase activity GO:0004857 enzyme inhibitor activity GO:0005515 protein binding GO:0016740 transferase activity GO:0019899 enzyme binding GO:0042393 histone binding GO:0044389 ubiquitin-like protein ligase binding GO:0072570 ADP-D-ribose binding GO:0097677 STAT family protein binding GO:0070403 NAD+ binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002230 positive regulation of defense response to virus by host GO:0002376 immune system process GO:0006281 DNA repair GO:0006302 double-strand break repair GO:0006471 protein ADP-ribosylation GO:0006974 cellular response to DNA damage stimulus GO:0010608 posttranscriptional regulation of gene expression GO:0010629 negative regulation of gene expression GO:0016477 cell migration GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0035563 positive regulation of chromatin binding GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043086 negative regulation of catalytic activity GO:0045087 innate immune response GO:0045893 positive regulation of transcription, DNA-templated GO:0051607 defense response to virus GO:0060330 regulation of response to interferon-gamma GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway GO:1900182 positive regulation of protein localization to nucleus GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining GO:0070212 protein poly-ADP-ribosylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
