Human Gene PARP11 (ENST00000228820.9_7) from GENCODE V47lift37
  Description: poly(ADP-ribose) polymerase family member 11, transcript variant 4 (from RefSeq NR_104461.2)
Gencode Transcript: ENST00000228820.9_7
Gencode Gene: ENSG00000111224.14_11
Transcript (Including UTRs)
   Position: hg19 chr12:3,918,027-3,982,565 Size: 64,539 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr12:3,921,289-3,982,395 Size: 61,107 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:3,918,027-3,982,565)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PAR11_HUMAN
DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 11; Short=PARP-11; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 11; Short=ARTD11;
CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
SIMILARITY: Contains 1 PARP catalytic domain.
SIMILARITY: Contains 1 WWE domain.
SEQUENCE CAUTION: Sequence=AAH17569.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH31073.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.55 RPKM in Testis
Total median expression: 80.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.50170-0.362 Picture PostScript Text
3' UTR -750.703262-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012317 - Poly(ADP-ribose)pol_cat_dom
IPR004170 - WWE-dom

Pfam Domains:
PF00644 - Poly(ADP-ribose) polymerase catalytic domain
PF02825 - WWE domain

SCOP Domains:
56399 - ADP-ribosylation
117839 - WWE domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2DK6 - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9NR21
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups

Biological Process:
GO:0006998 nuclear envelope organization
GO:0007283 spermatogenesis
GO:0015031 protein transport
GO:0030154 cell differentiation
GO:0051028 mRNA transport

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore


-  Descriptions from all associated GenBank mRNAs
  BC031073 - Homo sapiens poly (ADP-ribose) polymerase family, member 11, mRNA (cDNA clone MGC:33714 IMAGE:5284275), complete cds.
KJ902935 - Synthetic construct Homo sapiens clone ccsbBroadEn_12329 PARP11 gene, encodes complete protein.
CR749294 - Homo sapiens mRNA; cDNA DKFZp779H0122 (from clone DKFZp779H0122).
BX647487 - Homo sapiens mRNA; cDNA DKFZp686C13128 (from clone DKFZp686C13128).
BX640960 - Homo sapiens mRNA; cDNA DKFZp686D19169 (from clone DKFZp686D19169).
AK299372 - Homo sapiens cDNA FLJ52860 complete cds, highly similar to Homo sapiens poly (ADP-ribose) polymerase family, member 11 (PARP11), mRNA.
BC017569 - Homo sapiens poly (ADP-ribose) polymerase family, member 11, mRNA (cDNA clone MGC:22721 IMAGE:4077842), complete cds.
AF263540 - Homo sapiens MIB006 (C12orf6) mRNA, complete cds.
AK314916 - Homo sapiens cDNA, FLJ95824.
CU676008 - Synthetic construct Homo sapiens gateway clone IMAGE:100017035 5' read PARP11 mRNA.
HQ448712 - Synthetic construct Homo sapiens clone IMAGE:100072156; CCSB007564_02 poly (ADP-ribose) polymerase family, member 11 (PARP11) gene, encodes complete protein.
KJ902934 - Synthetic construct Homo sapiens clone ccsbBroadEn_12328 PARP11 gene, encodes complete protein.
AB529076 - Synthetic construct DNA, clone: pF1KB4080, Homo sapiens PARP11 gene for poly (ADP-ribose) polymerase family, member 11, without stop codon, in Flexi system.
AK096373 - Homo sapiens cDNA FLJ39054 fis, clone NT2RP7012516.
JD506190 - Sequence 487214 from Patent EP1572962.
JD490318 - Sequence 471342 from Patent EP1572962.
JD045002 - Sequence 26026 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DRQ0, C12orf6, ENST00000228820.1, ENST00000228820.2, ENST00000228820.3, ENST00000228820.4, ENST00000228820.5, ENST00000228820.6, ENST00000228820.7, ENST00000228820.8, F8WBZ7, NR_104461, PAR11_HUMAN, PARP11 , Q68DS1, Q8N5Y9, Q9NR21, uc317dor.1, uc317dor.2
UCSC ID: ENST00000228820.9_7
RefSeq Accession: NM_020367.6
Protein: Q9NR21 (aka PAR11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.