ID:PAEP_HUMAN DESCRIPTION: RecName: Full=Glycodelin; Short=GD; AltName: Full=Placental protein 14; Short=PP14; AltName: Full=Pregnancy-associated endometrial alpha-2 globulin; Short=PAEG; Short=PEG; AltName: Full=Progestagen-associated endometrial protein; AltName: Full=Progesterone-associated endometrial protein; Flags: Precursor; FUNCTION: This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Secreted. PTM: At least two differentially glycosylated forms are found. Glycodelin-A (GdA) (amniotic fluid) with contraceptive and immunosuppressive activities and glycodelin-S (Gds) (seminal plasma) whose role is not yet known. The gender-specific glycosylation may serve to regulate key process involved in human reproduction. SIMILARITY: Belongs to the calycin superfamily. Lipocalin family. SEQUENCE CAUTION: Sequence=AAA60147.1; Type=Erroneous initiation; Sequence=CAB43305.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09466
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0036094 small molecule binding
Biological Process: GO:0006915 apoptotic process GO:0007275 multicellular organism development GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:1902491 negative regulation of sperm capacitation GO:2000359 regulation of binding of sperm to zona pellucida GO:2000667 positive regulation of interleukin-13 secretion GO:2000778 positive regulation of interleukin-6 secretion
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
AK311730 - Homo sapiens cDNA, FLJ18772. AK311731 - Homo sapiens cDNA, FLJ18773. AK309965 - Homo sapiens cDNA, FLJ17007. AK309983 - Homo sapiens cDNA, FLJ17025. AK311007 - Homo sapiens cDNA, FLJ18049. AK311813 - Homo sapiens cDNA, FLJ92074, highly similar to Homo sapiens progestagen-associated endometrial protein (placentalprotein 14, pregnancy-associated endometrial alpha-2-globulin,alpha uterine protein) (PAEP), mRNA. AK304657 - Homo sapiens cDNA FLJ52183 complete cds, highly similar to Glycodelin precursor. J04129 - Human placental protein 14 (PP14) mRNA, complete cds. M61886 - Human pregnancy-associated endometrial alpha2-globulin mRNA, complete cds. AL050169 - Homo sapiens mRNA; cDNA DKFZp586D0922 (from clone DKFZp586D0922). JD115683 - Sequence 96707 from Patent EP1572962. BC069562 - Homo sapiens progestagen-associated endometrial protein, mRNA (cDNA clone MGC:96887 IMAGE:7262096), complete cds. BC069451 - Homo sapiens progestagen-associated endometrial protein, mRNA (cDNA clone MGC:96970 IMAGE:7262179), complete cds. AB528962 - Synthetic construct DNA, clone: pF1KB6873, Homo sapiens PAEP gene for progestagen-associated endometrial protein, without stop codon, in Flexi system. HQ258098 - Synthetic construct Homo sapiens clone IMAGE:100072407 progestagen-associated endometrial protein (PAEP), transcript variant 2 (PAEP) gene, encodes complete protein. CU686906 - Synthetic construct Homo sapiens gateway clone IMAGE:100022578 5' read PAEP mRNA. HQ448469 - Synthetic construct Homo sapiens clone IMAGE:100071898; CCSB013789_01 progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial a (PAEP) gene, encodes complete protein. KJ891746 - Synthetic construct Homo sapiens clone ccsbBroadEn_01140 PAEP gene, encodes complete protein. DQ884407 - Homo sapiens clone BFC06005 glycodelin precursor mRNA, complete cds. BC112304 - Homo sapiens progestagen-associated endometrial protein, mRNA (cDNA clone MGC:138509 IMAGE:8327772), complete cds. BC113728 - Homo sapiens progestagen-associated endometrial protein, mRNA (cDNA clone MGC:142288 IMAGE:8322780), complete cds. JD366081 - Sequence 347105 from Patent EP1572962. JD398221 - Sequence 379245 from Patent EP1572962. JD518327 - Sequence 499351 from Patent EP1572962. JD498173 - Sequence 479197 from Patent EP1572962. JD254124 - Sequence 235148 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
