Human Gene P2RY14 (ENST00000309170.8_7) from GENCODE V47lift37
  Description: purinergic receptor P2Y14, transcript variant 2 (from RefSeq NM_014879.4)
Gencode Transcript: ENST00000309170.8_7
Gencode Gene: ENSG00000174944.9_12
Transcript (Including UTRs)
   Position: hg19 chr3:150,929,905-150,996,330 Size: 66,426 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr3:150,931,088-150,932,104 Size: 1,017 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:150,929,905-150,996,330)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: P2Y14_HUMAN
DESCRIPTION: RecName: Full=P2Y purinoceptor 14; Short=P2Y14; AltName: Full=G-protein coupled receptor 105; AltName: Full=UDP-glucose receptor;
FUNCTION: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=BAA02791.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.34 RPKM in Bladder
Total median expression: 74.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.30388-0.210 Picture PostScript Text
3' UTR -215.901183-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor
IPR005466 - UDPG_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2B6V - Model


ModBase Predicted Comparative 3D Structure on Q15391
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0045028 G-protein coupled purinergic nucleotide receptor activity
GO:0045029 UDP-activated nucleotide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  D13626 - Homo sapiens KIAA0001 mRNA.
LP896296 - Sequence 1160 from Patent EP3253886.
BC034989 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 14, mRNA (cDNA clone MGC:33042 IMAGE:5265592), complete cds.
JD553113 - Sequence 534137 from Patent EP1572962.
JD238622 - Sequence 219646 from Patent EP1572962.
JD224861 - Sequence 205885 from Patent EP1572962.
JD413570 - Sequence 394594 from Patent EP1572962.
AK289617 - Homo sapiens cDNA FLJ75398 complete cds, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 14, mRNA.
EF577400 - Homo sapiens purinergic receptor P2Y G-protein coupled 14 transcript variant 2 mRNA, complete cds.
KJ898119 - Synthetic construct Homo sapiens clone ccsbBroadEn_07513 P2RY14 gene, encodes complete protein.
AB385264 - Synthetic construct DNA, clone: pF1KA0001, Homo sapiens P2RY14 gene for P2Y purinoceptor 14, complete cds, without stop codon, in Flexi system.
CU690010 - Synthetic construct Homo sapiens gateway clone IMAGE:100018142 5' read P2RY14 mRNA.
JD087984 - Sequence 69008 from Patent EP1572962.
JD088131 - Sequence 69155 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15391 (Reactome details) participates in the following event(s):

R-HSA-417858 P2Y14 receptor can bind to UDP-glucose
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-417957 P2Y receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-418038 Nucleotide-like (purinergic) receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000309170.1, ENST00000309170.2, ENST00000309170.3, ENST00000309170.4, ENST00000309170.5, ENST00000309170.6, ENST00000309170.7, GPR105, KIAA0001, NM_014879, P2Y14_HUMAN, Q15391, Q8IYT7, uc317oly.1, uc317oly.2
UCSC ID: ENST00000309170.8_7
RefSeq Accession: NM_014879.4
Protein: Q15391 (aka P2Y14_HUMAN or P2YE_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.