Human Gene NUDT6 (ENST00000304430.10_7) from GENCODE V47lift37
  Description: nudix hydrolase 6, transcript variant 1 (from RefSeq NM_007083.5)
Gencode Transcript: ENST00000304430.10_7
Gencode Gene: ENSG00000170917.14_13
Transcript (Including UTRs)
   Position: hg19 chr4:123,813,732-123,843,752 Size: 30,021 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr4:123,813,983-123,843,727 Size: 29,745 Coding Exon Count: 5 

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Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:123,813,732-123,843,752)mRNA (may differ from genome)Protein (316 aa)
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-  Comments and Description Text from UniProtKB
  ID: NUDT6_HUMAN
DESCRIPTION: RecName: Full=Nucleoside diphosphate-linked moiety X motif 6; Short=Nudix motif 6; AltName: Full=Antisense basic fibroblast growth factor; AltName: Full=Protein GFG;
FUNCTION: May contribute to the regulation of cell proliferation.
SUBUNIT: Monomer and homodimer (Probable).
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.
TISSUE SPECIFICITY: Detected in liver, kidney and esophagus (at protein level). Ubiquitous.
MISCELLANEOUS: This protein is coded from a FGF2 (BFGF) gene antisense transcript.
SIMILARITY: Belongs to the Nudix hydrolase family.
SIMILARITY: Contains 1 nudix hydrolase domain.
CAUTION: The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides. PubMed:17569023 found no such activity, neither for the human nor the rat protein.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NUDT6
Diseases sorted by gene-association score: prostatic adenoma (10), bone fracture (6), brain glioma (5), moyamoya disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.79 RPKM in Adrenal Gland
Total median expression: 64.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.8025-0.072 Picture PostScript Text
3' UTR -40.10251-0.160 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003293 - Nudix_hydrolase6-like
IPR020084 - NUDIX_hydrolase_CS
IPR000086 - NUDIX_hydrolase_dom
IPR015797 - NUDIX_hydrolase_dom-like

Pfam Domains:
PF00293 - NUDIX domain
PF18290 - Nudix hydrolase domain

SCOP Domains:
55811 - Nudix

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3FXT - X-ray MuPIT 3H95 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P53370
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008083 growth factor activity
GO:0016787 hydrolase activity

Biological Process:
GO:0008150 biological_process
GO:0010469 regulation of receptor activity

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  BC009842 - Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 6, mRNA (cDNA clone MGC:15270 IMAGE:3942416), complete cds.
AF019633 - Homo sapiens antisense basic fibroblast growth factor B alternatively spliced mRNA, complete cds.
AF019632 - Homo sapiens antisense basic fibroblast growth factor A mRNA, complete cds.
AK294450 - Homo sapiens cDNA FLJ52144 complete cds, highly similar to Nucleoside diphosphate-linked moiety X motif6.
JD563342 - Sequence 544366 from Patent EP1572962.
AK291871 - Homo sapiens cDNA FLJ75272 complete cds, highly similar to Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 6 (NUDT6), transcript variant 1, mRNA.
DQ893139 - Synthetic construct clone IMAGE:100005769; FLH194178.01X; RZPDo839G0479D nudix (nucleoside diphosphate linked moiety X)-type motif 6 (NUDT6) gene, encodes complete protein.
KJ898369 - Synthetic construct Homo sapiens clone ccsbBroadEn_07763 NUDT6 gene, encodes complete protein.
KR710368 - Synthetic construct Homo sapiens clone CCSBHm_00011957 NUDT6 (NUDT6) mRNA, encodes complete protein.
DQ896423 - Synthetic construct Homo sapiens clone IMAGE:100010883; FLH194174.01L; RZPDo839G0469D nudix (nucleoside diphosphate linked moiety X)-type motif 6 (NUDT6) gene, encodes complete protein.
AB209758 - Homo sapiens mRNA for nudix-type motif 6 isoform a variant protein.
AF086208 - Homo sapiens full length insert cDNA clone ZC48D12.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K756, ENST00000304430.1, ENST00000304430.2, ENST00000304430.3, ENST00000304430.4, ENST00000304430.5, ENST00000304430.6, ENST00000304430.7, ENST00000304430.8, ENST00000304430.9, FGF2AS, NM_007083, NUDT6_HUMAN, O95097, P53370, Q9UQD9, uc317nkv.1, uc317nkv.2
UCSC ID: ENST00000304430.10_7
RefSeq Accession: NM_007083.5
Protein: P53370 (aka NUDT6_HUMAN or NUD6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.