ID:NUDT6_HUMAN DESCRIPTION: RecName: Full=Nucleoside diphosphate-linked moiety X motif 6; Short=Nudix motif 6; AltName: Full=Antisense basic fibroblast growth factor; AltName: Full=Protein GFG; FUNCTION: May contribute to the regulation of cell proliferation. SUBUNIT: Monomer and homodimer (Probable). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms. TISSUE SPECIFICITY: Detected in liver, kidney and esophagus (at protein level). Ubiquitous. MISCELLANEOUS: This protein is coded from a FGF2 (BFGF) gene antisense transcript. SIMILARITY: Belongs to the Nudix hydrolase family. SIMILARITY: Contains 1 nudix hydrolase domain. CAUTION: The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides. PubMed:17569023 found no such activity, neither for the human nor the rat protein.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53370
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.