ID:NUCKS_HUMAN DESCRIPTION: RecName: Full=Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; AltName: Full=P1; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung. PTM: Phosphorylated by CDK1 and casein kinase. Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE CAUTION: Sequence=BAB15076.1; Type=Erroneous termination; Positions=164; Note=Translated as Arg; Sequence=CAC20412.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1E3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003682 chromatin binding GO:0003690 double-stranded DNA binding GO:0003697 single-stranded DNA binding GO:0003723 RNA binding GO:0008134 transcription factor binding
Biological Process: GO:0000724 double-strand break repair via homologous recombination GO:0001678 cellular glucose homeostasis GO:0006275 regulation of DNA replication GO:0006325 chromatin organization GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0019046 release from viral latency GO:0031297 replication fork processing GO:0035822 gene conversion GO:0036297 interstrand cross-link repair GO:0042593 glucose homeostasis GO:0043923 positive regulation by host of viral transcription GO:0044829 positive regulation by host of viral genome replication GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046626 regulation of insulin receptor signaling pathway GO:0046628 positive regulation of insulin receptor signaling pathway GO:0060382 regulation of DNA strand elongation GO:0071481 cellular response to X-ray GO:1990968 modulation by host of RNA binding by virus GO:1990969 modulation by host of viral RNA-binding transcription factor activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
