Human Gene NPY5R (ENST00000338566.8_4) from GENCODE V47lift37
  Description: neuropeptide Y receptor Y5, transcript variant 2 (from RefSeq NM_006174.4)
Gencode Transcript: ENST00000338566.8_4
Gencode Gene: ENSG00000164129.12_7
Transcript (Including UTRs)
   Position: hg19 chr4:164,265,044-164,273,086 Size: 8,043 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr4:164,271,426-164,272,763 Size: 1,338 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:164,265,044-164,273,086)mRNA (may differ from genome)Protein (445 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NPY5R_HUMAN
DESCRIPTION: RecName: Full=Neuropeptide Y receptor type 5; Short=NPY5-R; AltName: Full=NPY-Y5 receptor; Short=NPYY5-R; Short=Y5 receptor;
FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain; hypothalamus.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAC50623.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NPY5R
Diseases sorted by gene-association score: neuroblastoma (2), obesity (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.51 RPKM in Spleen
Total median expression: 36.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.40229-0.342 Picture PostScript Text
3' UTR -57.90323-0.179 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000393 - NPY5_rcpt
IPR000611 - NPY_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2HE6 - Model


ModBase Predicted Comparative 3D Structure on Q15761
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001601 peptide YY receptor activity
GO:0001602 pancreatic polypeptide receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity

Biological Process:
GO:0002675 positive regulation of acute inflammatory response
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0003151 outflow tract morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007568 aging
GO:0007631 feeding behavior
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0014050 negative regulation of glutamate secretion
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0042755 eating behavior
GO:0043066 negative regulation of apoptotic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0060112 generation of ovulation cycle rhythm
GO:0070374 positive regulation of ERK1 and ERK2 cascade

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  BC042416 - Homo sapiens neuropeptide Y receptor Y5, mRNA (cDNA clone MGC:34438 IMAGE:5191617), complete cds.
BC034224 - Homo sapiens neuropeptide Y receptor Y5, mRNA (cDNA clone IMAGE:4838926), with apparent retained intron.
JD044151 - Sequence 25175 from Patent EP1572962.
U94320 - Human neuropeptide Y5 receptor (NPYY5) mRNA, complete cds.
JD304210 - Sequence 285234 from Patent EP1572962.
U56079 - Human Y5 receptor mRNA, complete cds.
U66275 - Human neuropeptide Y5 receptor (NPYR5) mRNA, complete cds.
AB464637 - Synthetic construct DNA, clone: pF1KB8831, Homo sapiens NPY5R gene for neuropeptide Y receptor Y5, without stop codon, in Flexi system.
KJ897263 - Synthetic construct Homo sapiens clone ccsbBroadEn_06657 NPY5R gene, encodes complete protein.
JD509319 - Sequence 490343 from Patent EP1572962.
JD563133 - Sequence 544157 from Patent EP1572962.
JD285142 - Sequence 266166 from Patent EP1572962.
JD224073 - Sequence 205097 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15761 (Reactome details) participates in the following event(s):

R-HSA-388863 Neuropeptide Y receptors can bind neuropeptide Y-related peptides
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000338566.1, ENST00000338566.2, ENST00000338566.3, ENST00000338566.4, ENST00000338566.5, ENST00000338566.6, ENST00000338566.7, NM_006174, NPY5R_HUMAN, NPYR5, Q15761, Q6GTR7, Q92916, uc317vbq.1, uc317vbq.2
UCSC ID: ENST00000338566.8_4
RefSeq Accession: NM_006174.4
Protein: Q15761 (aka NPY5R_HUMAN or NY5R_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.