Human Gene NPB (ENST00000333383.8_5) from GENCODE V47lift37
  Description: neuropeptide B (from RefSeq NM_148896.5)
Gencode Transcript: ENST00000333383.8_5
Gencode Gene: ENSG00000183979.8_8
Transcript (Including UTRs)
   Position: hg19 chr17:79,860,114-79,860,781 Size: 668 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr17:79,860,154-79,860,624 Size: 471 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:79,860,114-79,860,781)mRNA (may differ from genome)Protein (125 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NPB_HUMAN
DESCRIPTION: RecName: Full=Neuropeptide B; AltName: Full=Preproprotein L7; Short=hPPL7; Contains: RecName: Full=Neuropeptide B-23; Short=NPB23; Short=hL7; Contains: RecName: Full=Neuropeptide B-29; Short=NPB29; Short=hL7C; Flags: Precursor;
FUNCTION: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.
SIMILARITY: Belongs to the neuropeptide B/W family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.6040-0.390 Picture PostScript Text
3' UTR -61.00157-0.389 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013298 - Neuropept_B_pre
IPR013297 - Neuropept_BW_pre

Pfam Domains:
PF15180 - Neuropeptides B and W

ModBase Predicted Comparative 3D Structure on Q8NG41
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001664 G-protein coupled receptor binding
GO:0005515 protein binding

Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  BC033173 - Homo sapiens neuropeptide B, mRNA (cDNA clone IMAGE:4558788), with apparent retained intron.
BC126128 - Homo sapiens neuropeptide B, mRNA (cDNA clone MGC:161406 IMAGE:8991844), complete cds.
BC126485 - Homo sapiens neuropeptide B, mRNA (cDNA clone MGC:161763 IMAGE:8992201), complete cds.
BC146875 - Homo sapiens neuropeptide B, mRNA (cDNA clone MGC:181978 IMAGE:9056803), complete cds.
BC146890 - Homo sapiens neuropeptide B, mRNA (cDNA clone MGC:181993 IMAGE:9056818), complete cds.
AF525737 - Homo sapiens preproprotein L7 (PPL7) mRNA, complete cds.
AF525738 - Homo sapiens preproprotein L7 (PPL7) precursor RNA, complete cds.
KJ895924 - Synthetic construct Homo sapiens clone ccsbBroadEn_05318 NPB gene, encodes complete protein.
AB085942 - Homo sapiens NPB mRNA for preproneuropeptide B, complete cds.
JD123884 - Sequence 104908 from Patent EP1572962.
JD173566 - Sequence 154590 from Patent EP1572962.
JD210313 - Sequence 191337 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8NG41 (Reactome details) participates in the following event(s):

R-HSA-374787 GPCR neuropeptide receptor binds neuropeptides B and W
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A0AUX9, A6NJD6, B9EJC3, ENST00000333383.1, ENST00000333383.2, ENST00000333383.3, ENST00000333383.4, ENST00000333383.5, ENST00000333383.6, ENST00000333383.7, NM_148896, NPB_HUMAN, PPL7, PPNPB, Q8NG41, uc317tqu.1, uc317tqu.2
UCSC ID: ENST00000333383.8_5
RefSeq Accession: NM_148896.5
Protein: Q8NG41 (aka NPB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.