ID:NOS1_HUMAN DESCRIPTION: RecName: Full=Nitric oxide synthase, brain; EC=1.14.13.39; AltName: Full=Constitutive NOS; AltName: Full=NC-NOS; AltName: Full=NOS type I; AltName: Full=Neuronal NOS; Short=N-NOS; Short=nNOS; AltName: Full=Peptidyl-cysteine S-nitrosylase NOS1; AltName: Full=bNOS; FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. CATALYTIC ACTIVITY: 2 L-arginine + 3 NADPH + 4 O(2) = 2 L- citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O. COFACTOR: Heme group. COFACTOR: Binds 1 FAD. COFACTOR: Binds 1 FMN. COFACTOR: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme. ENZYME REGULATION: Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP. SUBUNIT: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4. Interacts with VAC14 (By similarity). Interacts with SLC6A4 (By similarity). SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. DOMAIN: The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity). PTM: Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro) (By similarity). SIMILARITY: Belongs to the NOS family. SIMILARITY: Contains 1 FAD-binding FR-type domain. SIMILARITY: Contains 1 flavodoxin-like domain. SIMILARITY: Contains 1 PDZ (DHR) domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nos1/"; WEB RESOURCE: Name=Wikipedia; Note=Nitric oxide synthase entry; URL="http://en.wikipedia.org/wiki/Nitric_oxide_synthase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P29475
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001666 response to hypoxia GO:0002028 regulation of sodium ion transport GO:0006527 arginine catabolic process GO:0006809 nitric oxide biosynthetic process GO:0006941 striated muscle contraction GO:0007263 nitric oxide mediated signal transduction GO:0007520 myoblast fusion GO:0009408 response to heat GO:0010523 negative regulation of calcium ion transport into cytosol GO:0018119 peptidyl-cysteine S-nitrosylation GO:0031284 positive regulation of guanylate cyclase activity GO:0033555 multicellular organismal response to stress GO:0035066 positive regulation of histone acetylation GO:0042136 neurotransmitter biosynthetic process GO:0042311 vasodilation GO:0042738 exogenous drug catabolic process GO:0043267 negative regulation of potassium ion transport GO:0045454 cell redox homeostasis GO:0045776 negative regulation of blood pressure GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050767 regulation of neurogenesis GO:0051346 negative regulation of hydrolase activity GO:0051612 negative regulation of serotonin uptake GO:0051926 negative regulation of calcium ion transport GO:0055114 oxidation-reduction process GO:0055117 regulation of cardiac muscle contraction GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity GO:0071363 cellular response to growth factor stimulus GO:0098735 positive regulation of the force of heart contraction GO:0098924 retrograde trans-synaptic signaling by nitric oxide GO:1902307 positive regulation of sodium ion transmembrane transport GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1903779 regulation of cardiac conduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
