ID:IKBB_HUMAN DESCRIPTION: RecName: Full=NF-kappa-B inhibitor beta; Short=NF-kappa-BIB; AltName: Full=I-kappa-B-beta; Short=IkB-B; Short=IkB-beta; Short=IkappaBbeta; AltName: Full=Thyroid receptor-interacting protein 9; Short=TR-interacting protein 9; Short=TRIP-9; FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. SUBUNIT: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. INTERACTION: Q04206:RELA; NbExp=6; IntAct=EBI-352889, EBI-73886; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in all tissues examined. PTM: Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. SIMILARITY: Belongs to the NF-kappa-B inhibitor family. SIMILARITY: Contains 6 ANK repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/nfkbib/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15653
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF207579 - JP 2014500723-A/15082: Polycomb-Associated Non-Coding RNAs. AB362577 - Homo sapiens NFKBIB mRNA, partial cds, splicing variant 1. AB209784 - Homo sapiens mRNA for NF-kappaB inhibitor beta variant protein. AK290569 - Homo sapiens cDNA FLJ75324 complete cds, highly similar to Homo sapiens thyroid receptor interactor (TRIP9) gene. AK057862 - Homo sapiens cDNA FLJ25133 fis, clone CBR06869, highly similar to THYROID RECEPTOR INTERACTING PROTEIN 9. BC015528 - Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta, mRNA (cDNA clone MGC:9440 IMAGE:3903794), complete cds. AB463937 - Synthetic construct DNA, clone: pF1KB6482, Homo sapiens NFKBIB gene for nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor beta, without stop codon, in Flexi system. DQ890633 - Synthetic construct clone IMAGE:100003263; FLH164554.01X; RZPDo839H06162D nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB) gene, encodes complete protein. DQ893804 - Synthetic construct Homo sapiens clone IMAGE:100008264; FLH164550.01L; RZPDo839H06161D nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB) gene, encodes complete protein. CU677339 - Synthetic construct Homo sapiens gateway clone IMAGE:100017086 5' read NFKBIB mRNA. KJ891700 - Synthetic construct Homo sapiens clone ccsbBroadEn_01094 NFKBIB gene, encodes complete protein. BT006743 - Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta mRNA, complete cds. DQ601380 - Homo sapiens piRNA piR-39446, complete sequence. DQ581138 - Homo sapiens piRNA piR-49250, complete sequence. BC007197 - Homo sapiens, clone IMAGE:3631962, mRNA, partial cds. LF367249 - JP 2014500723-A/174752: Polycomb-Associated Non-Coding RNAs. LF367248 - JP 2014500723-A/174751: Polycomb-Associated Non-Coding RNAs. MA602826 - JP 2018138019-A/174752: Polycomb-Associated Non-Coding RNAs. MA602825 - JP 2018138019-A/174751: Polycomb-Associated Non-Coding RNAs. MA443156 - JP 2018138019-A/15082: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
Reactome (by CSHL, EBI, and GO)
Protein Q15653 (Reactome details) participates in the following event(s):
R-HSA-168140 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex R-HSA-1168638 Activated IKK phosphorylates I-kappaB R-HSA-1168642 SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-9020702 Interleukin-1 signaling R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-446652 Interleukin-1 family signaling R-HSA-168249 Innate Immune System R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-449147 Signaling by Interleukins R-HSA-168256 Immune System R-HSA-983705 Signaling by the B Cell Receptor (BCR) R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
