ID:SNAG_HUMAN DESCRIPTION: RecName: Full=Gamma-soluble NSF attachment protein; Short=SNAP-gamma; AltName: Full=N-ethylmaleimide-sensitive factor attachment protein gamma; FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. SUBUNIT: Binds RIP11. Interacts with VTI1A (By similarity). SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By similarity). SIMILARITY: Belongs to the SNAP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99747
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005483 soluble NSF attachment protein activity GO:0005515 protein binding GO:0019905 syntaxin binding
Biological Process: GO:0006886 intracellular protein transport GO:0006891 intra-Golgi vesicle-mediated transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0050821 protein stabilization GO:0061025 membrane fusion GO:0065003 macromolecular complex assembly
LF211072 - JP 2014500723-A/18575: Polycomb-Associated Non-Coding RNAs. AK294038 - Homo sapiens cDNA FLJ61104 complete cds, highly similar to Gamma-soluble NSF attachment protein. U78107 - Homo sapiens gamma SNAP mRNA, complete cds. AK314495 - Homo sapiens cDNA, FLJ95310, Homo sapiens N-ethylmaleimide-sensitive factor attachment protein,gamma (NAPG), mRNA. JD262012 - Sequence 243036 from Patent EP1572962. BC001889 - Homo sapiens N-ethylmaleimide-sensitive factor attachment protein, gamma, mRNA (cDNA clone MGC:1699 IMAGE:3536833), complete cds. JD062288 - Sequence 43312 from Patent EP1572962. CU674912 - Synthetic construct Homo sapiens gateway clone IMAGE:100018841 5' read NAPG mRNA. HQ447805 - Synthetic construct Homo sapiens clone IMAGE:100071148; CCSB003684_01 N-ethylmaleimide-sensitive factor attachment protein, gamma (NAPG) gene, encodes complete protein. KJ897902 - Synthetic construct Homo sapiens clone ccsbBroadEn_07296 NAPG gene, encodes complete protein. CR536554 - Homo sapiens full open reading frame cDNA clone RZPDo834G1020D for gene NAPG, N-ethylmaleimide-sensitive factor attachment protein, gamma; complete cds, incl. stopcodon. LQ827714 - Sequence 1 from Patent EP3348278. AK126942 - Homo sapiens cDNA FLJ44995 fis, clone BRAWH3010602, highly similar to Gamma-soluble NSF attachment protein. LF343745 - JP 2014500723-A/151248: Polycomb-Associated Non-Coding RNAs. LF343749 - JP 2014500723-A/151252: Polycomb-Associated Non-Coding RNAs. LF343750 - JP 2014500723-A/151253: Polycomb-Associated Non-Coding RNAs. AF131752 - Homo sapiens clone 25059 mRNA sequence. AK023725 - Homo sapiens cDNA FLJ13663 fis, clone PLACE1011646, highly similar to Homo sapiens clone 25059 mRNA sequence. JD333007 - Sequence 314031 from Patent EP1572962. JD108145 - Sequence 89169 from Patent EP1572962. JD146952 - Sequence 127976 from Patent EP1572962. JD460438 - Sequence 441462 from Patent EP1572962. LF343751 - JP 2014500723-A/151254: Polycomb-Associated Non-Coding RNAs. MA579322 - JP 2018138019-A/151248: Polycomb-Associated Non-Coding RNAs. MA579326 - JP 2018138019-A/151252: Polycomb-Associated Non-Coding RNAs. MA579327 - JP 2018138019-A/151253: Polycomb-Associated Non-Coding RNAs. MA579328 - JP 2018138019-A/151254: Polycomb-Associated Non-Coding RNAs. MA446649 - JP 2018138019-A/18575: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99747 (Reactome details) participates in the following event(s):
R-HSA-5694423 NSF and SNAPs bind cis-SNARE complex R-HSA-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs R-HSA-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane R-HSA-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN R-HSA-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN R-HSA-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi R-HSA-5694425 NSF ATPase activity dissociates cis-SNARE R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER R-HSA-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN R-HSA-6814683 NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN R-HSA-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane R-HSA-204005 COPII-mediated vesicle transport R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811438 Intra-Golgi traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
