Human Gene NAP1L1 (ENST00000618691.5_10) from GENCODE V47lift37
  Description: nucleosome assembly protein 1 like 1, transcript variant 1 (from RefSeq NM_139207.5)
Gencode Transcript: ENST00000618691.5_10
Gencode Gene: ENSG00000187109.15_20
Transcript (Including UTRs)
   Position: hg19 chr12:76,430,365-76,478,465 Size: 48,101 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr12:76,442,209-76,467,999 Size: 25,791 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:76,430,365-76,478,465)mRNA (may differ from genome)Protein (391 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NP1L1_HUMAN
DESCRIPTION: RecName: Full=Nucleosome assembly protein 1-like 1; AltName: Full=NAP-1-related protein; Short=hNRP; Flags: Precursor;
FUNCTION: May be involved in modulating chromatin formation and contribute to regulation of cell proliferation.
INTERACTION: Q92793:CREBBP; NbExp=3; IntAct=EBI-356392, EBI-81215; Q09472:EP300; NbExp=3; IntAct=EBI-356392, EBI-447295; P10588:NR2F6; NbExp=2; IntAct=EBI-356392, EBI-2681496;
SUBCELLULAR LOCATION: Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
TISSUE SPECIFICITY: Ubiquitously expressed.
DOMAIN: The acidic domains are probably involved in the interaction with histones.
PTM: Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity).
SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NAP1L1
Diseases sorted by gene-association score: antenatal bartter syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.10139-0.253 Picture PostScript Text
3' UTR -3316.9011844-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002164 - NAP_family

Pfam Domains:
PF00956 - Nucleosome assembly protein (NAP)

SCOP Domains:
143113 - NAP-like

ModBase Predicted Comparative 3D Structure on P55209
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0006260 DNA replication
GO:0006334 nucleosome assembly
GO:0008284 positive regulation of cell proliferation

Cellular Component:
GO:0005634 nucleus
GO:0016020 membrane
GO:0042470 melanosome


-  Descriptions from all associated GenBank mRNAs
  KJ897220 - Synthetic construct Homo sapiens clone ccsbBroadEn_06614 NAP1L1 gene, encodes complete protein.
JD344673 - Sequence 325697 from Patent EP1572962.
JD447075 - Sequence 428099 from Patent EP1572962.
JD344674 - Sequence 325698 from Patent EP1572962.
JD447076 - Sequence 428100 from Patent EP1572962.
JD430577 - Sequence 411601 from Patent EP1572962.
JD529938 - Sequence 510962 from Patent EP1572962.
JD557601 - Sequence 538625 from Patent EP1572962.
DL491650 - Novel nucleic acids.
DL490236 - Novel nucleic acids.
JD270145 - Sequence 251169 from Patent EP1572962.
JD365193 - Sequence 346217 from Patent EP1572962.
AK021751 - Homo sapiens cDNA FLJ11689 fis, clone HEMBA1004977.
AF086080 - Homo sapiens full length insert cDNA clone YZ83B08.
AF300335 - Homo sapiens HSP22-like protein interacting protein 27 mRNA, complete cds.
AL162068 - Homo sapiens mRNA; cDNA DKFZp762G106 (from clone DKFZp762G106).
JD304078 - Sequence 285102 from Patent EP1572962.
JD469605 - Sequence 450629 from Patent EP1572962.
JD301960 - Sequence 282984 from Patent EP1572962.
JD065479 - Sequence 46503 from Patent EP1572962.
JD019282 - Sequence 306 from Patent EP1572962.
JD032013 - Sequence 13037 from Patent EP1572962.
JD177607 - Sequence 158631 from Patent EP1572962.
JD160439 - Sequence 141463 from Patent EP1572962.
JD091209 - Sequence 72233 from Patent EP1572962.
JD545234 - Sequence 526258 from Patent EP1572962.
JD357793 - Sequence 338817 from Patent EP1572962.
AK298936 - Homo sapiens cDNA FLJ54129 complete cds, highly similar to Nucleosome assembly protein 1-like 1.
BC002387 - Homo sapiens nucleosome assembly protein 1-like 1, mRNA (cDNA clone MGC:8688 IMAGE:2964631), complete cds.
M86667 - H.sapiens NAP (nucleosome assembly protein) mRNA, complete cds.
JD562040 - Sequence 543064 from Patent EP1572962.
JD224998 - Sequence 206022 from Patent EP1572962.
JD295333 - Sequence 276357 from Patent EP1572962.
AK122670 - Homo sapiens cDNA FLJ16112 fis, clone 3NB692001853, highly similar to NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 1.
JD245359 - Sequence 226383 from Patent EP1572962.
JD290870 - Sequence 271894 from Patent EP1572962.
JD020404 - Sequence 1428 from Patent EP1572962.
AF088017 - Homo sapiens full length insert cDNA clone YY88A02.
JD408288 - Sequence 389312 from Patent EP1572962.
JD554255 - Sequence 535279 from Patent EP1572962.
AK297500 - Homo sapiens cDNA FLJ59349 complete cds, highly similar to Nucleosome assembly protein 1-like 1.
AK304787 - Homo sapiens cDNA FLJ58569 complete cds, highly similar to Nucleosome assembly protein 1-like 1.
JD031746 - Sequence 12770 from Patent EP1572962.
BT007023 - Homo sapiens nucleosome assembly protein 1-like 2 mRNA, complete cds.
DQ890701 - Synthetic construct clone IMAGE:100003331; FLH165280.01X; RZPDo839A05160D nucleosome assembly protein 1-like 1 (NAP1L1) gene, encodes complete protein.
DQ893550 - Synthetic construct Homo sapiens clone IMAGE:100006180; FLH263581.01X; RZPDo839A07160D nucleosome assembly protein 1-like 1 (NAP1L1) gene, encodes complete protein.
DQ893885 - Synthetic construct Homo sapiens clone IMAGE:100008345; FLH165276.01L; RZPDo839A05159D nucleosome assembly protein 1-like 1 (NAP1L1) gene, encodes complete protein.
EU176182 - Synthetic construct Homo sapiens clone IMAGE:100006614; FLH264071.01X; RZPDo839B06257D galactokinase 1 (GALK1) gene, encodes complete protein.
AB385088 - Synthetic construct DNA, clone: pF1KB5353, Homo sapiens NAP1L1 gene for nucleosome assembly protein 1-like 1, complete cds, without stop codon, in Flexi system.
AK295147 - Homo sapiens cDNA FLJ60539 complete cds, highly similar to Nucleosome assembly protein 1-like 1.
BC018565 - Homo sapiens nucleosome assembly protein 1-like 1, mRNA (cDNA clone IMAGE:4156011), with apparent retained intron.
AK055020 - Homo sapiens cDNA FLJ30458 fis, clone BRACE2009421, highly similar to NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 1.
JD020988 - Sequence 2012 from Patent EP1572962.
JD027121 - Sequence 8145 from Patent EP1572962.
JD027167 - Sequence 8191 from Patent EP1572962.
CU677938 - Synthetic construct Homo sapiens gateway clone IMAGE:100017164 5' read NAP1L1 mRNA.
JD182388 - Sequence 163412 from Patent EP1572962.
D28430 - Homo sapiens mRNA for nucleosome assembly protein, 5'UTR region.
JD124091 - Sequence 105115 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KNT8, B3KV44, ENST00000618691.1, ENST00000618691.2, ENST00000618691.3, ENST00000618691.4, NM_139207, NP1L1_HUMAN, NRP, P55209, uc327rwp.1, uc327rwp.2
UCSC ID: ENST00000618691.5_10
RefSeq Accession: NM_004537.7
Protein: P55209 (aka NP1L1_HUMAN or NPL1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.