Human Gene MYO1D (ENST00000318217.10_7) from GENCODE V47lift37
  Description: myosin ID, transcript variant 1 (from RefSeq NM_015194.3)
Gencode Transcript: ENST00000318217.10_7
Gencode Gene: ENSG00000176658.17_12
Transcript (Including UTRs)
   Position: hg19 chr17:30,819,540-31,204,142 Size: 384,603 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr17:30,821,777-31,203,890 Size: 382,114 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:30,819,540-31,204,142)mRNA (may differ from genome)Protein (1006 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MYO1D_HUMAN
DESCRIPTION: RecName: Full=Unconventional myosin-Id;
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
SUBUNIT: Binds calmodulin through its IQ motifs (By similarity).
TISSUE SPECIFICITY: Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.
SIMILARITY: Contains 2 IQ domains.
SIMILARITY: Contains 1 myosin head-like domain.
CAUTION: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
SEQUENCE CAUTION: Sequence=BAA34447.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MYO1D
Diseases sorted by gene-association score: visceral heterotaxy (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 117.13 RPKM in Artery - Aorta
Total median expression: 827.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -134.30252-0.533 Picture PostScript Text
3' UTR -871.502237-0.390 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR001609 - Myosin_head_motor_dom
IPR010926 - Myosin_tail_2

Pfam Domains:
PF00063 - Myosin head (motor domain)
PF00612 - IQ calmodulin-binding motif
PF06017 - Unconventional myosin tail, actin- and lipid-binding

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on O94832
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000146 microfilament motor activity
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0019904 protein domain specific binding
GO:0030898 actin-dependent ATPase activity
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding

Biological Process:
GO:0007018 microtubule-based movement
GO:0010923 negative regulation of phosphatase activity
GO:0030900 forebrain development
GO:0051641 cellular localization
GO:0061502 early endosome to recycling endosome transport

Cellular Component:
GO:0005768 endosome
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0005903 brush border
GO:0016323 basolateral plasma membrane
GO:0016459 myosin complex
GO:0030424 axon
GO:0030673 axolemma
GO:0031410 cytoplasmic vesicle
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0044853 plasma membrane raft
GO:0070062 extracellular exosome
GO:0097440 apical dendrite


-  Descriptions from all associated GenBank mRNAs
  BC030796 - Homo sapiens myosin ID, mRNA (cDNA clone IMAGE:3846889), partial cds.
AK026920 - Homo sapiens cDNA: FLJ23267 fis, clone COL07266.
BX537615 - Homo sapiens mRNA; cDNA DKFZp686A01173 (from clone DKFZp686A01173).
BC146763 - Homo sapiens myosin ID, mRNA (cDNA clone MGC:166833 IMAGE:9007203), complete cds.
AB018270 - Homo sapiens KIAA0727 mRNA for KIAA0727 protein.
AB385376 - Synthetic construct DNA, clone: pF1KA0727, Homo sapiens MYO1D gene for myosin-Id, complete cds, without stop codon, in Flexi system.
AK127942 - Homo sapiens cDNA FLJ46052 fis, clone SYNOV4003174, highly similar to Rattus norvegicus myosin 1C (Myo1c).
BC030602 - Homo sapiens myosin ID, mRNA (cDNA clone IMAGE:4824589), with apparent retained intron.
KJ901589 - Synthetic construct Homo sapiens clone ccsbBroadEn_10983 MYO1D gene, encodes complete protein.
CU688936 - Synthetic construct Homo sapiens gateway clone IMAGE:100019389 5' read MYO1D mRNA.
JD429728 - Sequence 410752 from Patent EP1572962.
AK026907 - Homo sapiens cDNA: FLJ23254 fis, clone COL05091.
JD152532 - Sequence 133556 from Patent EP1572962.
JD514766 - Sequence 495790 from Patent EP1572962.
JD415574 - Sequence 396598 from Patent EP1572962.
JD546429 - Sequence 527453 from Patent EP1572962.
JD234316 - Sequence 215340 from Patent EP1572962.
JD348552 - Sequence 329576 from Patent EP1572962.
JD358338 - Sequence 339362 from Patent EP1572962.
JD214390 - Sequence 195414 from Patent EP1572962.
JD513662 - Sequence 494686 from Patent EP1572962.
JD537493 - Sequence 518517 from Patent EP1572962.
JD041149 - Sequence 22173 from Patent EP1572962.
JD156779 - Sequence 137803 from Patent EP1572962.
JD222632 - Sequence 203656 from Patent EP1572962.
JD343904 - Sequence 324928 from Patent EP1572962.
JD495788 - Sequence 476812 from Patent EP1572962.
JD106990 - Sequence 88014 from Patent EP1572962.
JD076172 - Sequence 57196 from Patent EP1572962.
JD117758 - Sequence 98782 from Patent EP1572962.
JD421111 - Sequence 402135 from Patent EP1572962.
JD386668 - Sequence 367692 from Patent EP1572962.
JD367759 - Sequence 348783 from Patent EP1572962.
JD399488 - Sequence 380512 from Patent EP1572962.
JD455285 - Sequence 436309 from Patent EP1572962.
JD255496 - Sequence 236520 from Patent EP1572962.
JD274971 - Sequence 255995 from Patent EP1572962.
JD045526 - Sequence 26550 from Patent EP1572962.
JD077893 - Sequence 58917 from Patent EP1572962.
JD156999 - Sequence 138023 from Patent EP1572962.
JD338722 - Sequence 319746 from Patent EP1572962.
JD373840 - Sequence 354864 from Patent EP1572962.
JD308338 - Sequence 289362 from Patent EP1572962.
JD180573 - Sequence 161597 from Patent EP1572962.
JD180917 - Sequence 161941 from Patent EP1572962.
JD462175 - Sequence 443199 from Patent EP1572962.
JD383632 - Sequence 364656 from Patent EP1572962.
JD121084 - Sequence 102108 from Patent EP1572962.
JD154101 - Sequence 135125 from Patent EP1572962.
JD491708 - Sequence 472732 from Patent EP1572962.
JD524444 - Sequence 505468 from Patent EP1572962.
JD328959 - Sequence 309983 from Patent EP1572962.
JD428030 - Sequence 409054 from Patent EP1572962.
JD486709 - Sequence 467733 from Patent EP1572962.
JD423045 - Sequence 404069 from Patent EP1572962.
JD256075 - Sequence 237099 from Patent EP1572962.
JD382565 - Sequence 363589 from Patent EP1572962.
JD037072 - Sequence 18096 from Patent EP1572962.
JD518244 - Sequence 499268 from Patent EP1572962.
JD493366 - Sequence 474390 from Patent EP1572962.
KY966293 - Homo sapiens cell line 04T036 PPARD/MYO1D fusion mRNA, partial sequence.
JD461784 - Sequence 442808 from Patent EP1572962.
JD394976 - Sequence 376000 from Patent EP1572962.
JD210417 - Sequence 191441 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6H8V3, ENST00000318217.1, ENST00000318217.2, ENST00000318217.3, ENST00000318217.4, ENST00000318217.5, ENST00000318217.6, ENST00000318217.7, ENST00000318217.8, ENST00000318217.9, KIAA0727, MYO1D_HUMAN, NM_015194, O94832, Q8NHP9, uc317qku.1, uc317qku.2
UCSC ID: ENST00000318217.10_7
RefSeq Accession: NM_015194.3
Protein: O94832 (aka MYO1D_HUMAN or MY1D_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.