Human Gene MYBBP1A (ENST00000254718.9_12) from GENCODE V47lift37
  Description: MYB binding protein 1a, transcript variant 2 (from RefSeq NM_014520.4)
Gencode Transcript: ENST00000254718.9_12
Gencode Gene: ENSG00000132382.15_16
Transcript (Including UTRs)
   Position: hg19 chr17:4,442,199-4,458,679 Size: 16,481 Total Exon Count: 26 Strand: -
Coding Region
   Position: hg19 chr17:4,442,710-4,458,619 Size: 15,910 Coding Exon Count: 26 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:4,442,199-4,458,679)mRNA (may differ from genome)Protein (1328 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MBB1A_HUMAN
DESCRIPTION: RecName: Full=Myb-binding protein 1A;
FUNCTION: May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity).
SUBUNIT: Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar.
SEQUENCE CAUTION: Sequence=CAB66530.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.61 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 603.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.8060-0.347 Picture PostScript Text
3' UTR -197.80511-0.387 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR007015 - DNA_pol_V

Pfam Domains:
PF04931 - DNA polymerase phi

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q9BQG0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0001649 osteoblast differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0022904 respiratory electron transport chain
GO:0032922 circadian regulation of gene expression
GO:0042149 cellular response to glucose starvation
GO:0045815 positive regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048511 rhythmic process
GO:0071158 positive regulation of cell cycle arrest
GO:0071897 DNA biosynthetic process
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:2000210 positive regulation of anoikis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042564 NLS-dependent protein nuclear import complex
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LP896060 - Sequence 924 from Patent EP3253886.
AK303150 - Homo sapiens cDNA FLJ57836 complete cds, highly similar to Myb-binding protein 1A.
AL136595 - Homo sapiens mRNA; cDNA DKFZp761F0324 (from clone DKFZp761F0324).
BC050546 - Homo sapiens MYB binding protein (P160) 1a, mRNA (cDNA clone MGC:57635 IMAGE:5495483), complete cds.
AF147709 - Homo sapiens MYB-binding protein 1A (MYBBP1A) mRNA, complete cds.
EU832503 - Synthetic construct Homo sapiens clone HAIB:100067532; DKFZo008F1029 MYB binding protein (P160) 1a protein (MYBBP1A) gene, encodes complete protein.
AK307948 - Homo sapiens cDNA, FLJ97896.
AK301622 - Homo sapiens cDNA FLJ58434 complete cds, highly similar to Myb-binding protein 1A.
AL133098 - Homo sapiens mRNA; cDNA DKFZp434B1021 (from clone DKFZp434B1021).
BC000641 - Homo sapiens MYB binding protein (P160) 1a, mRNA (cDNA clone IMAGE:3343824), partial cds.
AK095205 - Homo sapiens cDNA FLJ37886 fis, clone BRTHA1000063, highly similar to MYB binding protein (P160) 1a.
AY093673 - Homo sapiens p53-activated protein-2 (PAP2) mRNA, complete cds.
JD330140 - Sequence 311164 from Patent EP1572962.
JD231269 - Sequence 212293 from Patent EP1572962.
JD291037 - Sequence 272061 from Patent EP1572962.
JD152600 - Sequence 133624 from Patent EP1572962.
JD458641 - Sequence 439665 from Patent EP1572962.
AK293458 - Homo sapiens cDNA FLJ60422 complete cds, highly similar to Myb-binding protein 1A.
JD191031 - Sequence 172055 from Patent EP1572962.
JD210304 - Sequence 191328 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BQG0 (Reactome details) participates in the following event(s):

R-HSA-5250947 B-WICH complex binds rDNA promoter
R-HSA-5250930 B-WICH recruits histone acetyltransferases
R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000254718.1, ENST00000254718.2, ENST00000254718.3, ENST00000254718.4, ENST00000254718.5, ENST00000254718.6, ENST00000254718.7, ENST00000254718.8, MBB1A_HUMAN, NM_014520, P160, Q86VM3, Q9BQG0, Q9BW49, Q9P0V5, Q9UF99, uc317fpe.1, uc317fpe.2
UCSC ID: ENST00000254718.9_12
RefSeq Accession: NM_014520.4
Protein: Q9BQG0 (aka MBB1A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.