Human Gene MPZL2 (ENST00000278937.7_7) from GENCODE V47lift37
  Description: myelin protein zero like 2, transcript variant 1 (from RefSeq NM_005797.4)
Gencode Transcript: ENST00000278937.7_7
Gencode Gene: ENSG00000149573.9_9
Transcript (Including UTRs)
   Position: hg19 chr11:118,124,131-118,135,012 Size: 10,882 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr11:118,127,965-118,134,868 Size: 6,904 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:118,124,131-118,135,012)mRNA (may differ from genome)Protein (215 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MPZL2_HUMAN
DESCRIPTION: RecName: Full=Myelin protein zero-like protein 2; AltName: Full=Epithelial V-like antigen 1; Flags: Precursor;
FUNCTION: Mediates homophilic cell-cell adhesion.
INTERACTION: Q6UWV2:MPZL3; NbExp=3; IntAct=EBI-3906725, EBI-4314854;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Probable).
TISSUE SPECIFICITY: Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.
SIMILARITY: Belongs to the myelin P0 protein family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 109.03 RPKM in Esophagus - Mucosa
Total median expression: 524.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.80144-0.374 Picture PostScript Text
3' UTR -402.801830-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013106 - Ig_V-set
IPR003596 - Ig_V-set_subgr
IPR000920 - Myelin_P0

Pfam Domains:
PF00047 - Immunoglobulin domain
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on O60487
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0009653 anatomical structure morphogenesis
GO:0098609 cell-cell adhesion

Cellular Component:
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF275945 - Homo sapiens epithelial V-like antigen 1 (EVA1) mRNA, complete cds.
AF304447 - Homo sapiens epithelial V-like antigen 1 (EVA1) mRNA, complete cds.
JD243729 - Sequence 224753 from Patent EP1572962.
JD301451 - Sequence 282475 from Patent EP1572962.
JD317157 - Sequence 298181 from Patent EP1572962.
JD110697 - Sequence 91721 from Patent EP1572962.
JD551430 - Sequence 532454 from Patent EP1572962.
JD378915 - Sequence 359939 from Patent EP1572962.
JD110765 - Sequence 91789 from Patent EP1572962.
JD494807 - Sequence 475831 from Patent EP1572962.
JD121206 - Sequence 102230 from Patent EP1572962.
JD101679 - Sequence 82703 from Patent EP1572962.
JD292737 - Sequence 273761 from Patent EP1572962.
JD186401 - Sequence 167425 from Patent EP1572962.
AY359061 - Homo sapiens clone DNA62814 EVA1 (UNQ606) mRNA, complete cds.
JD236453 - Sequence 217477 from Patent EP1572962.
AF030455 - Homo sapiens epithelial V-like antigen precursor (EVA) mRNA, complete cds.
JD244969 - Sequence 225993 from Patent EP1572962.
AK290326 - Homo sapiens cDNA FLJ76084 complete cds, highly similar to Homo sapiens epithelial V-like antigen 1 (EVA1), transcript variant 1, mRNA.
JD309385 - Sequence 290409 from Patent EP1572962.
JD264391 - Sequence 245415 from Patent EP1572962.
BC017774 - Homo sapiens myelin protein zero-like 2, mRNA (cDNA clone MGC:22243 IMAGE:4692569), complete cds.
CU676056 - Synthetic construct Homo sapiens gateway clone IMAGE:100022142 5' read MPZL2 mRNA.
HQ447755 - Synthetic construct Homo sapiens clone IMAGE:100071086; CCSB012997_01 epithelial V-like antigen 1 (MPZL2) gene, encodes complete protein.
KJ892959 - Synthetic construct Homo sapiens clone ccsbBroadEn_02353 MPZL2 gene, encodes complete protein.
JD403267 - Sequence 384291 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K2R1, ENST00000278937.1, ENST00000278937.2, ENST00000278937.3, ENST00000278937.4, ENST00000278937.5, ENST00000278937.6, EVA , EVA1, MPZL2_HUMAN, NM_005797, O60487, uc317jqn.1, uc317jqn.2, UNQ606/PRO1192
UCSC ID: ENST00000278937.7_7
RefSeq Accession: NM_005797.4
Protein: O60487 (aka MPZL2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.