ID:MMP7_HUMAN DESCRIPTION: RecName: Full=Matrilysin; EC=3.4.24.23; AltName: Full=Matrin; AltName: Full=Matrix metalloproteinase-7; Short=MMP-7; AltName: Full=Pump-1 protease; AltName: Full=Uterine metalloproteinase; Flags: Precursor; FUNCTION: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. CATALYTIC ACTIVITY: Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu- 17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I). COFACTOR: Binds 2 calcium ions per subunit. COFACTOR: Binds 2 zinc ions per subunit. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (Probable). DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. SIMILARITY: Belongs to the peptidase M10A family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp7/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09237
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Z11887 - H.sapiens PUMP-1 gene encoding PUMP. BC003635 - Homo sapiens matrix metallopeptidase 7 (matrilysin, uterine), mRNA (cDNA clone MGC:3913 IMAGE:3545760), complete cds. AK222980 - Homo sapiens mRNA for matrix metalloproteinase 7 preproprotein variant, clone: HSI04850. X07819 - Human pump-1 mRNA homolog. to metalloproteinase, collagenase and stromelysin. JD308330 - Sequence 289354 from Patent EP1572962. JD501342 - Sequence 482366 from Patent EP1572962. JD502038 - Sequence 483062 from Patent EP1572962. DQ893132 - Synthetic construct clone IMAGE:100005762; FLH194090.01X; RZPDo839F0479D matrix metallopeptidase 7 (matrilysin, uterine) (MMP7) gene, encodes complete protein. EU176770 - Synthetic construct Homo sapiens clone IMAGE:100011628; FLH263977.01L; RZPDo839B03245D matrix metallopeptidase 7 (matrilysin, uterine) (MMP7) gene, encodes complete protein. KJ897196 - Synthetic construct Homo sapiens clone ccsbBroadEn_06590 MMP7 gene, encodes complete protein. AB528509 - Synthetic construct DNA, clone: pF1KB6357, Homo sapiens MMP7 gene for matrix metallopeptidase 7, without stop codon, in Flexi system. CU678546 - Synthetic construct Homo sapiens gateway clone IMAGE:100018673 5' read MMP7 mRNA. AK309687 - Homo sapiens cDNA, FLJ99728. DQ399600 - Homo sapiens matrix metalloproteinase 7 (MMP7) mRNA, partial cds. AK293359 - Homo sapiens cDNA FLJ56650 complete cds, highly similar to Matrilysin precursor (EC 3.4.24.23).
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P09237 (Reactome details) participates in the following event(s):
R-HSA-1592362 Activation of proMMP7 by MMP3 R-HSA-1604763 Autocatalytic activation of MMP7 R-HSA-1604712 Initial activation of proMMP7 by trypsin R-HSA-1454791 MMP2, MMP7, MMP9 bind CD44 R-HSA-1454781 MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin R-HSA-8940561 MMP7 cleaves OPTC R-HSA-1604359 Initial activation of proMMP2 by MMP1, 7 R-HSA-1592297 Full activation of MMP1 R-HSA-1564142 Collagen type IV degradation by MMP2,3,4,9,10,12 R-HSA-2168923 Collagen type XVIII endostatin release R-HSA-1566962 Elastin degradation by elastin-degrading extracellular proteinases R-HSA-1566981 Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS R-HSA-2533970 NID1 degradation by MMP3, 7 R-HSA-4086205 OPN (osteopontin) degradation by MMP3, MMP7 R-HSA-2534248 DCN (decorin) degradation by MMP2, MMP3, MMP7 R-HSA-1454843 E-cadherin degradation by MMP3, MMP7 and plasmin. R-NUL-2534162 E-cadherin strand dimer degradation by MMP3, MMP7 and Plasmin R-HSA-1566979 Laminin-332 degradation by laminin-322 degrading extracellular proteinases R-HSA-3791149 Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 R-HSA-3791295 Aggrecan degradation by MMP1,2,3,7,9,12,13 R-NUL-3814821 Aggrecan degradation by MMP1,2,3,7,9,12,13 R-HSA-1592436 Initial activation of proMMP9 by MMPs R-HSA-1604690 Activation of MMP9 intermediate form by MMPs R-HSA-2213200 Release of endostatin-like peptides R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1442490 Collagen degradation R-HSA-1474244 Extracellular matrix organization R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-1474290 Collagen formation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
