ID:MMP12_HUMAN DESCRIPTION: RecName: Full=Macrophage metalloelastase; Short=MME; EC=3.4.24.65; AltName: Full=Macrophage elastase; Short=ME; Short=hME; AltName: Full=Matrix metalloproteinase-12; Short=MMP-12; Flags: Precursor; FUNCTION: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. CATALYTIC ACTIVITY: Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16- Tyr-|-Leu-17 in the B chain of insulin. COFACTOR: Binds 4 calcium ions per subunit. COFACTOR: Binds 2 zinc ions per subunit. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (Probable). TISSUE SPECIFICITY: Found in alveolar macrophages but not in peripheral blood monocytes. INDUCTION: By exposure to bacterial lipopolysaccharides (LPS). Inhibited by dexamethasone. DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. SIMILARITY: Belongs to the peptidase M10A family. SIMILARITY: Contains 4 hemopexin-like domains. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp12/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P39900
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006508 proteolysis GO:0006606 protein import into nucleus GO:0010628 positive regulation of gene expression GO:0022617 extracellular matrix disassembly GO:0030574 collagen catabolic process GO:0035313 wound healing, spreading of epidermal cells GO:0042060 wound healing GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050691 regulation of defense response to virus by host GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing GO:0060339 negative regulation of type I interferon-mediated signaling pathway GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0098586 cellular response to virus GO:1902741 positive regulation of interferon-alpha secretion
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
