ID:MK15_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase 15; Short=MAP kinase 15; Short=MAPK 15; EC=2.7.11.24; AltName: Full=Extracellular signal-regulated kinase 7; Short=ERK-7; AltName: Full=Extracellular signal-regulated kinase 8; Short=ERK-8; FUNCTION: In vitro, phosphorylates MBP. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity). SUBUNIT: Interacts with CSK/c-Src, ABL1, RET and TGFB1I1. TISSUE SPECIFICITY: Widely expressed with a maximal expression in lung and kidney. DOMAIN: The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation (By similarity). DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. PTM: Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro. PTM: Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q8TD08
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0003400 regulation of COPII vesicle coating GO:0006468 protein phosphorylation GO:0007029 endoplasmic reticulum organization GO:0010468 regulation of gene expression GO:0010506 regulation of autophagy GO:0016310 phosphorylation GO:0030336 negative regulation of cell migration GO:0032212 positive regulation of telomere maintenance via telomerase GO:0046777 protein autophosphorylation GO:0051973 positive regulation of telomerase activity GO:0090494 dopamine uptake GO:1902017 regulation of cilium assembly GO:1904355 positive regulation of telomere capping GO:1904491 protein localization to ciliary transition zone GO:1905188 positive regulation of metaphase/anaphase transition of meiosis I
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
