Human Gene MAP4K4 (ENST00000324219.9_8) from GENCODE V47lift37
  Description: mitogen-activated protein kinase kinase kinase kinase 4, transcript variant 33 (from RefSeq NR_169280.1)
Gencode Transcript: ENST00000324219.9_8
Gencode Gene: ENSG00000071054.17_19
Transcript (Including UTRs)
   Position: hg19 chr2:102,314,169-102,511,152 Size: 196,984 Total Exon Count: 33 Strand: +
Coding Region
   Position: hg19 chr2:102,314,543-102,507,711 Size: 193,169 Coding Exon Count: 33 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:102,314,169-102,511,152)mRNA (may differ from genome)Protein (1384 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MAP4K4
Diseases sorted by gene-association score: theileriasis (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 69.92 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 886.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -210.70374-0.563 Picture PostScript Text
3' UTR -929.003441-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001180 - Citron
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF00780 - CNH domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
103657 - BAR/IMD domain-like
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on G5E948
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation


-  Descriptions from all associated GenBank mRNAs
  BC156089 - Synthetic construct Homo sapiens clone IMAGE:100062311, MGC:190457 mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) mRNA, encodes complete protein.
BC156887 - Synthetic construct Homo sapiens clone IMAGE:100062694, MGC:190587 mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) mRNA, encodes complete protein.
LF205186 - JP 2014500723-A/12689: Polycomb-Associated Non-Coding RNAs.
BC064691 - Homo sapiens cDNA clone IMAGE:30343496, containing frame-shift errors.
AK296396 - Homo sapiens cDNA FLJ60617 complete cds, highly similar to Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1).
AF096300 - Homo sapiens HPK/GCK-like kinase HGK mRNA, complete cds.
EU794634 - Homo sapiens epididymis secretory protein Li 31 (HEL-S-31) mRNA, complete cds.
AB384511 - Synthetic construct DNA, clone: pF1KA0687, Homo sapiens MAP4K4 gene for mitogen-activated protein kinase kinase kinase kinase 4, complete cds, without stop codon, in Flexi system.
AY834276 - Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 isoform (MAP4K4) mRNA, complete cds, alternatively spliced.
AY212247 - Homo sapiens Ste20 group protein kinase HGK mRNA, complete cds, alternatively spliced.
AB014587 - Homo sapiens mRNA for KIAA0687 protein, partial cds.
AK295610 - Homo sapiens cDNA FLJ56564 complete cds, highly similar to Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1).
AL137755 - Homo sapiens mRNA; cDNA DKFZp434A025 (from clone DKFZp434A025).
AK025610 - Homo sapiens cDNA: FLJ21957 fis, clone HEP05344.
AK001272 - Homo sapiens cDNA FLJ10410 fis, clone NT2RP1000018, highly similar to Homo sapiens mRNA for KIAA0687 protein.
AB013385 - Homo sapiens mRNA for NIK, partial cds.
AK074592 - Homo sapiens cDNA FLJ90111 fis, clone HEMBA1006658.
MA440763 - JP 2018138019-A/12689: Polycomb-Associated Non-Coding RNAs.
JD342709 - Sequence 323733 from Patent EP1572962.
AK307879 - Homo sapiens cDNA, FLJ97827.
LF317473 - JP 2014500723-A/124976: Polycomb-Associated Non-Coding RNAs.
LF317478 - JP 2014500723-A/124981: Polycomb-Associated Non-Coding RNAs.
AK074900 - Homo sapiens cDNA FLJ90419 fis, clone NT2RP3000201.
LF317481 - JP 2014500723-A/124984: Polycomb-Associated Non-Coding RNAs.
LF317482 - JP 2014500723-A/124985: Polycomb-Associated Non-Coding RNAs.
LF317483 - JP 2014500723-A/124986: Polycomb-Associated Non-Coding RNAs.
LF317484 - JP 2014500723-A/124987: Polycomb-Associated Non-Coding RNAs.
LF317485 - JP 2014500723-A/124988: Polycomb-Associated Non-Coding RNAs.
LF317486 - JP 2014500723-A/124989: Polycomb-Associated Non-Coding RNAs.
LF317489 - JP 2014500723-A/124992: Polycomb-Associated Non-Coding RNAs.
LF317490 - JP 2014500723-A/124993: Polycomb-Associated Non-Coding RNAs.
LF317494 - JP 2014500723-A/124997: Polycomb-Associated Non-Coding RNAs.
LF317497 - JP 2014500723-A/125000: Polycomb-Associated Non-Coding RNAs.
LF317498 - JP 2014500723-A/125001: Polycomb-Associated Non-Coding RNAs.
LF317500 - JP 2014500723-A/125003: Polycomb-Associated Non-Coding RNAs.
LF317501 - JP 2014500723-A/125004: Polycomb-Associated Non-Coding RNAs.
LF317502 - JP 2014500723-A/125005: Polycomb-Associated Non-Coding RNAs.
LF317503 - JP 2014500723-A/125006: Polycomb-Associated Non-Coding RNAs.
LF317507 - JP 2014500723-A/125010: Polycomb-Associated Non-Coding RNAs.
MA553050 - JP 2018138019-A/124976: Polycomb-Associated Non-Coding RNAs.
MA553055 - JP 2018138019-A/124981: Polycomb-Associated Non-Coding RNAs.
MA553058 - JP 2018138019-A/124984: Polycomb-Associated Non-Coding RNAs.
MA553059 - JP 2018138019-A/124985: Polycomb-Associated Non-Coding RNAs.
MA553060 - JP 2018138019-A/124986: Polycomb-Associated Non-Coding RNAs.
MA553061 - JP 2018138019-A/124987: Polycomb-Associated Non-Coding RNAs.
MA553062 - JP 2018138019-A/124988: Polycomb-Associated Non-Coding RNAs.
MA553063 - JP 2018138019-A/124989: Polycomb-Associated Non-Coding RNAs.
MA553066 - JP 2018138019-A/124992: Polycomb-Associated Non-Coding RNAs.
MA553067 - JP 2018138019-A/124993: Polycomb-Associated Non-Coding RNAs.
MA553071 - JP 2018138019-A/124997: Polycomb-Associated Non-Coding RNAs.
MA553074 - JP 2018138019-A/125000: Polycomb-Associated Non-Coding RNAs.
MA553075 - JP 2018138019-A/125001: Polycomb-Associated Non-Coding RNAs.
MA553077 - JP 2018138019-A/125003: Polycomb-Associated Non-Coding RNAs.
MA553078 - JP 2018138019-A/125004: Polycomb-Associated Non-Coding RNAs.
MA553079 - JP 2018138019-A/125005: Polycomb-Associated Non-Coding RNAs.
MA553080 - JP 2018138019-A/125006: Polycomb-Associated Non-Coding RNAs.
MA553084 - JP 2018138019-A/125010: Polycomb-Associated Non-Coding RNAs.
LF317508 - JP 2014500723-A/125011: Polycomb-Associated Non-Coding RNAs.
LF317509 - JP 2014500723-A/125012: Polycomb-Associated Non-Coding RNAs.
LF317511 - JP 2014500723-A/125014: Polycomb-Associated Non-Coding RNAs.
LF317512 - JP 2014500723-A/125015: Polycomb-Associated Non-Coding RNAs.
JD343474 - Sequence 324498 from Patent EP1572962.
JD040934 - Sequence 21958 from Patent EP1572962.
JD221010 - Sequence 202034 from Patent EP1572962.
JD082420 - Sequence 63444 from Patent EP1572962.
LF317513 - JP 2014500723-A/125016: Polycomb-Associated Non-Coding RNAs.
LF317514 - JP 2014500723-A/125017: Polycomb-Associated Non-Coding RNAs.
BC045694 - Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4, mRNA (cDNA clone IMAGE:5302120).
BC054038 - Homo sapiens cDNA clone IMAGE:6148395, partial cds.
BC010909 - Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4, mRNA (cDNA clone IMAGE:4279933), partial cds.
BC040077 - Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4, mRNA (cDNA clone IMAGE:6046237).
LF317515 - JP 2014500723-A/125018: Polycomb-Associated Non-Coding RNAs.
BC065036 - Homo sapiens cDNA clone IMAGE:6171234.
BC051791 - Homo sapiens cDNA clone IMAGE:5403532, partial cds.
AK000380 - Homo sapiens cDNA FLJ20373 fis, clone HEP19740.
JD243063 - Sequence 224087 from Patent EP1572962.
JD428043 - Sequence 409067 from Patent EP1572962.
LF317516 - JP 2014500723-A/125019: Polycomb-Associated Non-Coding RNAs.
AK130085 - Homo sapiens cDNA FLJ26575 fis, clone LNF06540.
JD286340 - Sequence 267364 from Patent EP1572962.
JD081939 - Sequence 62963 from Patent EP1572962.
JD305865 - Sequence 286889 from Patent EP1572962.
JD040516 - Sequence 21540 from Patent EP1572962.
JD440416 - Sequence 421440 from Patent EP1572962.
JD498432 - Sequence 479456 from Patent EP1572962.
JD305368 - Sequence 286392 from Patent EP1572962.
JD494977 - Sequence 476001 from Patent EP1572962.
JD419891 - Sequence 400915 from Patent EP1572962.
JD092579 - Sequence 73603 from Patent EP1572962.
JD485737 - Sequence 466761 from Patent EP1572962.
JD288723 - Sequence 269747 from Patent EP1572962.
JD490858 - Sequence 471882 from Patent EP1572962.
JD124439 - Sequence 105463 from Patent EP1572962.
JD555976 - Sequence 537000 from Patent EP1572962.
MA553085 - JP 2018138019-A/125011: Polycomb-Associated Non-Coding RNAs.
MA553086 - JP 2018138019-A/125012: Polycomb-Associated Non-Coding RNAs.
MA553088 - JP 2018138019-A/125014: Polycomb-Associated Non-Coding RNAs.
MA553089 - JP 2018138019-A/125015: Polycomb-Associated Non-Coding RNAs.
MA553090 - JP 2018138019-A/125016: Polycomb-Associated Non-Coding RNAs.
MA553091 - JP 2018138019-A/125017: Polycomb-Associated Non-Coding RNAs.
MA553092 - JP 2018138019-A/125018: Polycomb-Associated Non-Coding RNAs.
MA553093 - JP 2018138019-A/125019: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mapkPathway - MAPKinase Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000324219.1, ENST00000324219.2, ENST00000324219.3, ENST00000324219.4, ENST00000324219.5, ENST00000324219.6, ENST00000324219.7, ENST00000324219.8, G5E948, G5E948_HUMAN, MAP4K4 , NR_169280, uc317rpr.1, uc317rpr.2
UCSC ID: ENST00000324219.9_8
RefSeq Accession: NM_001395002.1
Protein: G5E948

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.