Human Gene LYZ (ENST00000261267.7_4) from GENCODE V47lift37
  Description: lysozyme (from RefSeq NM_000239.3)
Gencode Transcript: ENST00000261267.7_4
Gencode Gene: ENSG00000090382.7_7
Transcript (Including UTRs)
   Position: hg19 chr12:69,742,161-69,748,014 Size: 5,854 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr12:69,742,189-69,746,999 Size: 4,811 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:69,742,161-69,748,014)mRNA (may differ from genome)Protein (148 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LYSC_HUMAN
DESCRIPTION: RecName: Full=Lysozyme C; EC=3.2.1.17; AltName: Full=1,4-beta-N-acetylmuramidase C; Flags: Precursor;
FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents.
CATALYTIC ACTIVITY: Hydrolysis of (1->4)-beta-linkages between N- acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Secreted.
DISEASE: Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
MISCELLANEOUS: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
SEQUENCE CAUTION: Sequence=CAA32175.1; Type=Erroneous initiation;
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LYZ";
WEB RESOURCE: Name=Wikipedia; Note=Lysozyme entry; URL="http://en.wikipedia.org/wiki/Lysozyme";

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LYZ
Diseases sorted by gene-association score: amyloidosis, familial visceral* (608), al amyloidosis* (350), lyz-related familial visceral amyloidosis* (100), amyloidosis (39), reticulohistiocytic granuloma (16), kidney papillary necrosis (15), cerebral sarcoidosis (15), congenital granular cell tumor (14), ulcerative blepharitis (10), malignant fibroxanthoma (9), erysipeloid (9), adult xanthogranuloma (8), haemophilus meningitis (8), meningitis (8), microscopic colitis (8), malignant giant cell tumor of soft parts (7), auditory system cancer (7), melanotic neurilemmoma (7), blue toe syndrome (7), hereditary amyloidosis (7), cutaneous solitary mastocytoma (7), paralytic lagophthalmos (6), central nervous system sarcoma (6), laryngeal tuberculosis (6), acute proliferative glomerulonephritis (6), retinitis pigmentosa 7 and digenic (6), dental caries (6), granulomatous myositis (6), diffuse glomerulonephritis (6), letterer-siwe disease (6), hypersensitivity reaction type iv disease (6), interdigitating dendritic cell sarcoma (6), lobomycosis (6), dermis tumor (6), juvenile xanthogranuloma (6), tuberculous meningitis (6), carbuncle (6), chronic laryngitis (5), erysipelas (5), liver sarcoma (5), pleomorphic adenoma carcinoma (5), periodic fever, familial (5), histiocytic and dendritic cell cancer (5), corneal dystrophy, congenital stromal (5), ulcerative stomatitis (5), renal tuberculosis (5), pulmonary hemosiderosis (5), pyelitis (5), xanthogranulomatous pyelonephritis (4), aleukemic leukemia cutis (4), lung sarcoma (4), in situ pulmonary adenocarcinoma (4), neuroretinitis (4), lymphatic system cancer (4), congenital epulis (4), xanthogranulomatous cholecystitis (4), retinal hemangioblastoma (4), acute salpingitis (4), lymphangiosarcoma (4), nodular nonsuppurative panniculitis (3), urinary system disease (1), leber congenital amaurosis (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5371.11 RPKM in Minor Salivary Gland
Total median expression: 7249.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.8028-0.100 Picture PostScript Text
3' UTR -251.901015-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001916 - Glyco_hydro_22
IPR019799 - Glyco_hydro_22_CS
IPR000974 - Glyco_hydro_22_lys
IPR023346 - Lysozyme-like_dom

Pfam Domains:
PF00062 - C-type lysozyme/alpha-lactalbumin family

SCOP Domains:
53955 - Lysozyme-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
133L - X-ray MuPIT 134L - X-ray MuPIT 1B5U - X-ray 1B5V - X-ray 1B5W - X-ray 1B5X - X-ray 1B5Y - X-ray 1B5Z - X-ray 1B7L - X-ray 1B7M - X-ray 1B7N - X-ray 1B7O - X-ray 1B7P - X-ray 1B7Q - X-ray 1B7R - X-ray 1B7S - X-ray 1BB3 - X-ray MuPIT 1BB4 - X-ray MuPIT 1BB5 - X-ray MuPIT 1C43 - X-ray MuPIT 1C45 - X-ray MuPIT 1C46 - X-ray MuPIT 1C7P - X-ray MuPIT 1CJ6 - X-ray 1CJ7 - X-ray 1CJ8 - X-ray 1CJ9 - X-ray 1CKC - X-ray 1CKD - X-ray 1CKF - X-ray 1CKG - X-ray 1CKH - X-ray 1D6P - X-ray MuPIT 1D6Q - X-ray MuPIT 1DI3 - X-ray 1DI4 - X-ray 1DI5 - X-ray 1EQ4 - X-ray 1EQ5 - X-ray 1EQE - X-ray 1GAY - X-ray 1GAZ - X-ray 1GB0 - X-ray 1GB2 - X-ray 1GB3 - X-ray 1GB5 - X-ray 1GB6 - X-ray 1GB7 - X-ray 1GB8 - X-ray 1GB9 - X-ray 1GBO - X-ray 1GBW - X-ray 1GBX - X-ray 1GBY - X-ray 1GBZ - X-ray 1GDW - X-ray 1GDX - X-ray 1GE0 - X-ray 1GE1 - X-ray 1GE2 - X-ray 1GE3 - X-ray 1GE4 - X-ray 1GEV - X-ray 1GEZ - X-ray 1GF0 - X-ray 1GF3 - X-ray 1GF4 - X-ray 1GF5 - X-ray 1GF6 - X-ray 1GF7 - X-ray 1GF8 - X-ray 1GF9 - X-ray 1GFA - X-ray 1GFE - X-ray 1GFG - X-ray 1GFH - X-ray 1GFJ - X-ray 1GFK - X-ray 1GFR - X-ray 1GFT - X-ray 1GFU - X-ray 1GFV - X-ray 1HNL - X-ray MuPIT 1I1Z - X-ray 1I20 - X-ray 1I22 - X-ray 1INU - X-ray 1IOC - X-ray MuPIT 1IP1 - X-ray 1IP2 - X-ray 1IP3 - X-ray 1IP4 - X-ray 1IP5 - X-ray 1IP6 - X-ray 1IP7 - X-ray 1IWT - X-ray 1IWU - X-ray 1IWV - X-ray 1IWW - X-ray 1IWX - X-ray 1IWY - X-ray 1IWZ - X-ray 1IX0 - X-ray 1IY3 - NMR MuPIT 1IY4 - NMR MuPIT 1JKA - X-ray 1JKB - X-ray 1JKC - X-ray 1JKD - X-ray 1JSF - X-ray 1JWR - X-ray MuPIT 1LAA - X-ray MuPIT 1LHH - X-ray MuPIT 1LHI - X-ray MuPIT 1LHJ - X-ray MuPIT 1LHK - X-ray MuPIT 1LHL - X-ray MuPIT 1LHM - X-ray MuPIT 1LMT - X-ray MuPIT 1LOZ - X-ray MuPIT 1LYY - X-ray MuPIT 1LZ1 - X-ray MuPIT 1LZ4 - X-ray MuPIT 1LZ5 - X-ray MuPIT 1LZ6 - X-ray MuPIT 1LZR - X-ray MuPIT 1LZS - X-ray MuPIT 1OP9 - X-ray MuPIT 1OUA - X-ray 1OUB - X-ray 1OUC - X-ray 1OUD - X-ray 1OUE - X-ray 1OUF - X-ray 1OUG - X-ray 1OUH - X-ray 1OUI - X-ray 1OUJ - X-ray 1QSW - X-ray 1RE2 - X-ray 1REM - X-ray 1REX - X-ray 1REY - X-ray 1REZ - X-ray 1TAY - X-ray MuPIT 1TBY - X-ray MuPIT 1TCY - X-ray MuPIT 1TDY - X-ray MuPIT 1UBZ - X-ray 1W08 - X-ray MuPIT 1WQM - X-ray 1WQN - X-ray 1WQO - X-ray 1WQP - X-ray 1WQQ - X-ray 1WQR - X-ray 1YAM - X-ray 1YAN - X-ray 1YAO - X-ray 1YAP - X-ray 1YAQ - X-ray 207L - X-ray MuPIT 208L - X-ray MuPIT 2BQA - X-ray 2BQB - X-ray 2BQC - X-ray 2BQD - X-ray 2BQE - X-ray 2BQF - X-ray 2BQG - X-ray 2BQH - X-ray 2BQI - X-ray 2BQJ - X-ray 2BQK - X-ray 2BQL - X-ray 2BQM - X-ray 2BQN - X-ray 2BQO - X-ray 2HEA - X-ray 2HEB - X-ray 2HEC - X-ray 2HED - X-ray 2HEE - X-ray 2HEF - X-ray 2LHM - X-ray MuPIT 2MEA - X-ray 2MEB - X-ray 2MEC - X-ray 2MED - X-ray 2MEE - X-ray 2MEF - X-ray 2MEG - X-ray 2MEH - X-ray 2MEI - X-ray 2NWD - X-ray 2ZIJ - X-ray MuPIT 2ZIK - X-ray MuPIT 2ZIL - X-ray 2ZWB - Neutron MuPIT 3EBA - X-ray MuPIT 3FE0 - X-ray MuPIT 3LHM - X-ray MuPIT 3LN2 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P61626
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
   Gene Details  
   Gene Sorter  
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003796 lysozyme activity
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding

Biological Process:
GO:0001895 retina homeostasis
GO:0006954 inflammatory response
GO:0008152 metabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0019730 antimicrobial humoral response
GO:0019835 cytolysis
GO:0031640 killing of cells of other organism
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0044267 cellular protein metabolic process
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0070062 extracellular exosome
GO:1904724 tertiary granule lumen


-  Descriptions from all associated GenBank mRNAs
  FJ795023 - Homo sapiens lysozyme (LYZ) mRNA, complete cds.
AK130149 - Homo sapiens cDNA FLJ26639 fis, clone MPE01811, highly similar to Lysozyme C precursor (EC 3.2.1.17).
LQ740463 - Sequence 17 from Patent WO2018083189.
AK311779 - Homo sapiens cDNA, FLJ92040, Homo sapiens lysozyme (renal amyloidosis) (LYZ), mRNA.
AK310930 - Homo sapiens cDNA, FLJ17972.
J03801 - Human lysozyme mRNA, complete cds with an Alu repeat in the 3' flank.
BC004147 - Homo sapiens lysozyme (renal amyloidosis), mRNA (cDNA clone MGC:2337 IMAGE:2959387), complete cds.
M21119 - Human lysozyme mRNA, complete cds.
M19045 - Human lysozyme mRNA, complete cds.
E01888 - cDNA sequence of human lysozyme.
E02193 - DNA encoding human lysozyme.
AB463851 - Synthetic construct DNA, clone: pF1KB6764, Homo sapiens LYZ gene for lysozyme, without stop codon, in Flexi system.
DQ895472 - Synthetic construct Homo sapiens clone IMAGE:100009932; FLH184747.01L; RZPDo839B06145D lysozyme (renal amyloidosis) (LYZ) gene, encodes complete protein.
DQ892271 - Synthetic construct clone IMAGE:100004901; FLH184751.01X; RZPDo839B06146D lysozyme (renal amyloidosis) (LYZ) gene, encodes complete protein.
KJ891562 - Synthetic construct Homo sapiens clone ccsbBroadEn_00956 LYZ gene, encodes complete protein.
KR710276 - Synthetic construct Homo sapiens clone CCSBHm_00011044 LYZ (LYZ) mRNA, encodes complete protein.
KR710277 - Synthetic construct Homo sapiens clone CCSBHm_00011045 LYZ (LYZ) mRNA, encodes complete protein.
KR710278 - Synthetic construct Homo sapiens clone CCSBHm_00011046 LYZ (LYZ) mRNA, encodes complete protein.
KR710279 - Synthetic construct Homo sapiens clone CCSBHm_00011049 LYZ (LYZ) mRNA, encodes complete protein.
KJ841928 - Homo sapiens c-type lysozyme precursor, mRNA, complete cds.
U25677 - Homo sapiens lysozyme precursor, mRNA, complete cds.
A10156 - H.sapiens mRNA for lysozyme protein.
JD528647 - Sequence 509671 from Patent EP1572962.
JD162941 - Sequence 143965 from Patent EP1572962.
AK130127 - Homo sapiens cDNA FLJ26617 fis, clone MPB08676.
JD514110 - Sequence 495134 from Patent EP1572962.
JD105111 - Sequence 86135 from Patent EP1572962.
JD070236 - Sequence 51260 from Patent EP1572962.
JD397880 - Sequence 378904 from Patent EP1572962.
JD416303 - Sequence 397327 from Patent EP1572962.
JD206044 - Sequence 187068 from Patent EP1572962.
JD083644 - Sequence 64668 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P61626 (Reactome details) participates in the following event(s):

R-HSA-8862300 LYZ binds bacterial peptidoglycan
R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798745 Exocytosis of tertiary granule lumen proteins
R-HSA-6798749 Exocytosis of specific granule lumen proteins
R-HSA-6803157 Antimicrobial peptides
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-977225 Amyloid fiber formation
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000261267.1, ENST00000261267.2, ENST00000261267.3, ENST00000261267.4, ENST00000261267.5, ENST00000261267.6, LYSC_HUMAN, LZM, NM_000239, P00695, P61626, Q13170, Q9UCF8, uc317goj.1, uc317goj.2
UCSC ID: ENST00000261267.7_4
RefSeq Accession: NM_000239.3
Protein: P61626 (aka LYSC_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.