Human Gene LYPLAL1 (ENST00000366928.10_4) from GENCODE V47lift37
  Description: lysophospholipase like 1, transcript variant 1 (from RefSeq NM_138794.5)
Gencode Transcript: ENST00000366928.10_4
Gencode Gene: ENSG00000143353.12_7
Transcript (Including UTRs)
   Position: hg19 chr1:219,347,220-219,386,200 Size: 38,981 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr1:219,347,233-219,385,070 Size: 37,838 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:219,347,220-219,386,200)mRNA (may differ from genome)Protein (237 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LYPL1_HUMAN
DESCRIPTION: RecName: Full=Lysophospholipase-like protein 1; EC=3.1.2.-;
FUNCTION: Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the AB hydrolase 2 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.93 RPKM in Adrenal Gland
Total median expression: 283.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -201.401130-0.178 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003140 - PLipase/COase/thioEstase

Pfam Domains:
PF00756 - Putative esterase
PF01738 - Dienelactone hydrolase family
PF02230 - Phospholipase/Carboxylesterase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
53474 - alpha/beta-Hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3U0V - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q5VWZ2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004622 lysophospholipase activity
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity

Biological Process:
GO:0002084 protein depalmitoylation
GO:0008150 biological_process

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF205506 - JP 2014500723-A/13009: Polycomb-Associated Non-Coding RNAs.
LP895163 - Sequence 27 from Patent EP3253886.
AK309689 - Homo sapiens cDNA, FLJ99730.
AK123628 - Homo sapiens cDNA FLJ41634 fis, clone FCBBF4000076, highly similar to Lysophospholipase-like protein 1 (EC 3.1.2.-).
AK291542 - Homo sapiens cDNA FLJ77315 complete cds, highly similar to Homo sapiens lysophospholipase-like 1 (LYPLAL1), mRNA.
BC016711 - Homo sapiens lysophospholipase-like 1, mRNA (cDNA clone MGC:23770 IMAGE:4133970), complete cds.
AK129913 - Homo sapiens cDNA FLJ26403 fis, clone HRT09070.
KJ895427 - Synthetic construct Homo sapiens clone ccsbBroadEn_04821 LYPLAL1 gene, encodes complete protein.
AY341430 - Homo sapiens lysophospholipase-like 1 (LYPLAL1) mRNA, complete cds; alternatively spliced.
MA441083 - JP 2018138019-A/13009: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K677, ENST00000366928.1, ENST00000366928.2, ENST00000366928.3, ENST00000366928.4, ENST00000366928.5, ENST00000366928.6, ENST00000366928.7, ENST00000366928.8, ENST00000366928.9, LYPL1_HUMAN, LYPLAL1 , NM_138794, Q5VWZ2, Q5VWZ3, Q7Z4A3, Q96AV0, uc318fmc.1, uc318fmc.2
UCSC ID: ENST00000366928.10_4
RefSeq Accession: NM_138794.5
Protein: Q5VWZ2 (aka LYPL1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.