Human Gene LRP10 (ENST00000359591.9_7) from GENCODE V47lift37
  Description: LDL receptor related protein 10, transcript variant 1 (from RefSeq NM_014045.5)
Gencode Transcript: ENST00000359591.9_7
Gencode Gene: ENSG00000197324.9_12
Transcript (Including UTRs)
   Position: hg19 chr14:23,340,949-23,350,922 Size: 9,974 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr14:23,341,513-23,346,736 Size: 5,224 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:23,340,949-23,350,922)mRNA (may differ from genome)Protein (713 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LRP10_HUMAN
DESCRIPTION: RecName: Full=Low-density lipoprotein receptor-related protein 10; Short=LRP-10; Flags: Precursor;
FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Membrane, coated pit (By similarity).
TISSUE SPECIFICITY: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.
SIMILARITY: Belongs to the LDLR family.
SIMILARITY: Contains 2 CUB domains.
SIMILARITY: Contains 4 LDL-receptor class A domains.
SEQUENCE CAUTION: Sequence=AAD20037.1; Type=Erroneous initiation; Sequence=AAG17980.1; Type=Frameshift; Positions=370, 700; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 78.85 RPKM in Whole Blood
Total median expression: 1811.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -304.30564-0.540 Picture PostScript Text
3' UTR -1501.804186-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000859 - CUB
IPR023415 - LDLR_class-A_CS
IPR002172 - LDrepeatLR_classA_rpt

Pfam Domains:
PF00057 - Low-density lipoprotein receptor domain class A
PF00431 - CUB domain

SCOP Domains:
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module

ModBase Predicted Comparative 3D Structure on Q7Z4F1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005041 low-density lipoprotein receptor activity

Biological Process:
GO:0006629 lipid metabolic process
GO:0006869 lipid transport
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0048839 inner ear development

Cellular Component:
GO:0005905 clathrin-coated pit
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF210070 - JP 2014500723-A/17573: Polycomb-Associated Non-Coding RNAs.
AY358399 - Homo sapiens clone DNA49631 LRP10 (UNQ389) mRNA, complete cds.
BX161500 - human full-length cDNA clone CS0DK002YO06 of HeLa cells of Homo sapiens (human).
AL834518 - Homo sapiens mRNA; cDNA DKFZp434J2419 (from clone DKFZp434J2419).
AK291030 - Homo sapiens cDNA FLJ76802 complete cds, highly similar to Homo sapiens low density lipoprotein receptor-related protein 10(LRP10), mRNA.
DL492023 - Novel nucleic acids.
DL490575 - Novel nucleic acids.
BC113716 - Homo sapiens low density lipoprotein receptor-related protein 10, mRNA (cDNA clone MGC:142276 IMAGE:8322768), complete cds.
BC113714 - Homo sapiens low density lipoprotein receptor-related protein 10, mRNA (cDNA clone MGC:142274 IMAGE:8322766), complete cds.
BC064901 - Homo sapiens low density lipoprotein receptor-related protein 10, mRNA (cDNA clone IMAGE:6009130), partial cds.
AF172816 - Homo sapiens MSTP087 (MST087) mRNA, complete cds.
DQ591106 - Homo sapiens piRNA piR-58218, complete sequence.
BC000424 - Homo sapiens low density lipoprotein receptor-related protein 10, mRNA (cDNA clone IMAGE:2964526), partial cds.
BC018816 - Homo sapiens low density lipoprotein receptor-related protein 10, mRNA (cDNA clone IMAGE:2964550).
AF177336 - Homo sapiens clone SP220 unknown mRNA.
BC088378 - Homo sapiens low density lipoprotein receptor-related protein 10, mRNA (cDNA clone IMAGE:6183907), partial cds.
JD282372 - Sequence 263396 from Patent EP1572962.
AF131760 - Homo sapiens clone 24992 mRNA sequence, complete cds.
JD136859 - Sequence 117883 from Patent EP1572962.
JD194019 - Sequence 175043 from Patent EP1572962.
JD538614 - Sequence 519638 from Patent EP1572962.
JD329710 - Sequence 310734 from Patent EP1572962.
AL080164 - Homo sapiens mRNA; cDNA DKFZp564C1940 (from clone DKFZp564C1940); partial cds.
JD266890 - Sequence 247914 from Patent EP1572962.
JD538156 - Sequence 519180 from Patent EP1572962.
BC080648 - Homo sapiens low density lipoprotein receptor-related protein 10, mRNA (cDNA clone IMAGE:6728330), partial cds.
JD425980 - Sequence 407004 from Patent EP1572962.
JD155542 - Sequence 136566 from Patent EP1572962.
CR457151 - Homo sapiens full open reading frame cDNA clone RZPDo834C048D for gene LRP10, low density lipoprotein receptor-related protein 10; complete cds, incl. stopcodon.
LF334462 - JP 2014500723-A/141965: Polycomb-Associated Non-Coding RNAs.
LF334464 - JP 2014500723-A/141967: Polycomb-Associated Non-Coding RNAs.
LF334465 - JP 2014500723-A/141968: Polycomb-Associated Non-Coding RNAs.
AL110149 - Homo sapiens mRNA; cDNA DKFZp586C0624 (from clone DKFZp586C0624).
LF334466 - JP 2014500723-A/141969: Polycomb-Associated Non-Coding RNAs.
JD218118 - Sequence 199142 from Patent EP1572962.
JD544781 - Sequence 525805 from Patent EP1572962.
JD487143 - Sequence 468167 from Patent EP1572962.
JD460201 - Sequence 441225 from Patent EP1572962.
JD393136 - Sequence 374160 from Patent EP1572962.
JD082395 - Sequence 63419 from Patent EP1572962.
JD502917 - Sequence 483941 from Patent EP1572962.
JD119628 - Sequence 100652 from Patent EP1572962.
JD498009 - Sequence 479033 from Patent EP1572962.
JD507504 - Sequence 488528 from Patent EP1572962.
JD526507 - Sequence 507531 from Patent EP1572962.
JD366850 - Sequence 347874 from Patent EP1572962.
JD145617 - Sequence 126641 from Patent EP1572962.
JD178842 - Sequence 159866 from Patent EP1572962.
JD344935 - Sequence 325959 from Patent EP1572962.
JD097006 - Sequence 78030 from Patent EP1572962.
JD043987 - Sequence 25011 from Patent EP1572962.
JD273521 - Sequence 254545 from Patent EP1572962.
LF334467 - JP 2014500723-A/141970: Polycomb-Associated Non-Coding RNAs.
AK025898 - Homo sapiens cDNA: FLJ22245 fis, clone HRC02612.
JD136160 - Sequence 117184 from Patent EP1572962.
JD243197 - Sequence 224221 from Patent EP1572962.
JD079526 - Sequence 60550 from Patent EP1572962.
JD238374 - Sequence 219398 from Patent EP1572962.
JD047622 - Sequence 28646 from Patent EP1572962.
JD457017 - Sequence 438041 from Patent EP1572962.
JD117520 - Sequence 98544 from Patent EP1572962.
JD447280 - Sequence 428304 from Patent EP1572962.
JD454283 - Sequence 435307 from Patent EP1572962.
JD056822 - Sequence 37846 from Patent EP1572962.
JD139081 - Sequence 120105 from Patent EP1572962.
JD089588 - Sequence 70612 from Patent EP1572962.
JD430447 - Sequence 411471 from Patent EP1572962.
JD529656 - Sequence 510680 from Patent EP1572962.
JD170166 - Sequence 151190 from Patent EP1572962.
JD170164 - Sequence 151188 from Patent EP1572962.
JD170165 - Sequence 151189 from Patent EP1572962.
JD307029 - Sequence 288053 from Patent EP1572962.
JD322911 - Sequence 303935 from Patent EP1572962.
JD194344 - Sequence 175368 from Patent EP1572962.
JD401564 - Sequence 382588 from Patent EP1572962.
JD401565 - Sequence 382589 from Patent EP1572962.
JD401566 - Sequence 382590 from Patent EP1572962.
JD425040 - Sequence 406064 from Patent EP1572962.
JD025078 - Sequence 6102 from Patent EP1572962.
JD029898 - Sequence 10922 from Patent EP1572962.
JD031072 - Sequence 12096 from Patent EP1572962.
MA445647 - JP 2018138019-A/17573: Polycomb-Associated Non-Coding RNAs.
MA570039 - JP 2018138019-A/141965: Polycomb-Associated Non-Coding RNAs.
MA570041 - JP 2018138019-A/141967: Polycomb-Associated Non-Coding RNAs.
MA570042 - JP 2018138019-A/141968: Polycomb-Associated Non-Coding RNAs.
MA570043 - JP 2018138019-A/141969: Polycomb-Associated Non-Coding RNAs.
MA570044 - JP 2018138019-A/141970: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z4F1 (Reactome details) participates in the following event(s):

R-HSA-2404131 LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
R-HSA-975634 Retinoid metabolism and transport
R-HSA-2187338 Visual phototransduction
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-418594 G alpha (i) signalling events
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-388396 GPCR downstream signalling
R-HSA-1430728 Metabolism
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K4R5, D3DS31, ENST00000359591.1, ENST00000359591.2, ENST00000359591.3, ENST00000359591.4, ENST00000359591.5, ENST00000359591.6, ENST00000359591.7, ENST00000359591.8, LRP10_HUMAN, MSTP087, NM_014045, O95882, Q14CK7, Q7Z4F1, Q86T02, Q8NCZ4, Q9HC42, Q9UG33, SP220, uc318bcx.1, uc318bcx.2, UNQ389/PRO724
UCSC ID: ENST00000359591.9_7
RefSeq Accession: NM_014045.5
Protein: Q7Z4F1 (aka LRP10_HUMAN or LR10_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.