Human Gene PLPPR3 (ENST00000359894.6_5) from GENCODE V47lift37
  Description: phospholipid phosphatase related 3, transcript variant 1 (from RefSeq NM_024888.3)
Gencode Transcript: ENST00000359894.6_5
Gencode Gene: ENSG00000129951.19_15
Transcript (Including UTRs)
   Position: hg19 chr19:812,488-821,952 Size: 9,465 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr19:812,570-821,559 Size: 8,990 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:812,488-821,952)mRNA (may differ from genome)Protein (746 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LPPR3_HUMAN
DESCRIPTION: RecName: Full=Lipid phosphate phosphatase-related protein type 3; EC=3.1.3.4; AltName: Full=PAP-2-like protein 2; AltName: Full=Plasticity-related gene 2 protein; Short=PRG-2;
CATALYTIC ACTIVITY: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.59 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 132.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.0064-0.484 Picture PostScript Text
3' UTR -35.1082-0.428 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016118 - P_Acid_Pase/Cl_peroxidase_N
IPR000326 - P_Acid_Pase_2/haloperoxidase

Pfam Domains:
PF01569 - PAP2 superfamily

SCOP Domains:
48317 - Acid phosphatase/Vanadium-dependent haloperoxidase

ModBase Predicted Comparative 3D Structure on Q6T4P5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008195 phosphatidate phosphatase activity
GO:0016787 hydrolase activity
GO:0042577 lipid phosphatase activity

Biological Process:
GO:0006644 phospholipid metabolic process
GO:0007165 signal transduction
GO:0046839 phospholipid dephosphorylation

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF357888 - Homo sapiens PAP-2-like protein 2 (PHP2) mRNA, complete cds.
BC017295 - Homo sapiens plasticity-related gene 2, mRNA (cDNA clone IMAGE:4909159), with apparent retained intron.
BC012339 - Homo sapiens plasticity-related gene 2, mRNA (cDNA clone IMAGE:4635163), partial cds.
AK021597 - Homo sapiens cDNA FLJ11535 fis, clone HEMBA1002703.
AY436785 - Homo sapiens plasticity related gene 2a mRNA, complete cds; alternatively spliced.
AF541282 - Homo sapiens plasticity related gene 2 mRNA, complete cds; alternatively spliced.
AL136596 - Homo sapiens mRNA; cDNA DKFZp761F069 (from clone DKFZp761F069).
AY304517 - Homo sapiens lipid phosphate phosphatase-related protein type 3 mRNA, complete cds.
JD485642 - Sequence 466666 from Patent EP1572962.
HZ481194 - JP 2015535430-A/1700: TERMINALLY MODIFIED RNA.
HZ791125 - JP 2016504050-A/2870: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC513857 - Sequence 4110 from Patent WO2014113089.
LQ071445 - Sequence 1769 from Patent EP2964234.
HZ481193 - JP 2015535430-A/1699: TERMINALLY MODIFIED RNA.
HZ791124 - JP 2016504050-A/2869: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC513856 - Sequence 4109 from Patent WO2014113089.
LQ071444 - Sequence 1768 from Patent EP2964234.
MA644946 - JP 2017113010-A/2870: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA732830 - JP 2017140048-A/1700: TERMINALLY MODIFIED RNA.
MA644945 - JP 2017113010-A/2869: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA732829 - JP 2017140048-A/1699: TERMINALLY MODIFIED RNA.
MA801999 - JP 2018183181-A/2870: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA801998 - JP 2018183181-A/2869: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6T4P5 (Reactome details) participates in the following event(s):

R-HSA-6797630 LRPP4(LRPP1-3,5) hydrolyse LPA
R-HSA-419408 Lysosphingolipid and LPA receptors
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000359894.1, ENST00000359894.2, ENST00000359894.3, ENST00000359894.4, ENST00000359894.5, LPPR3 , NM_024888, PHP2 , PLPPR3 , PLPR3_HUMAN, PRG2 , Q6T4P5, Q86XQ4, Q96EH1, Q9BQF9, Q9HAJ4, uc318bgx.1, uc318bgx.2
UCSC ID: ENST00000359894.6_5
RefSeq Accession: NM_024888.3
Protein: Q6T4P5 (aka LPPR3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.