ID:PCAT1_HUMAN DESCRIPTION: RecName: Full=Lysophosphatidylcholine acyltransferase 1; Short=LPC acyltransferase 1; Short=LPCAT-1; Short=LysoPC acyltransferase 1; EC=2.3.1.-; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; EC=2.3.1.23; AltName: Full=1-alkylglycerophosphocholine O-acetyltransferase; EC=2.3.1.67; AltName: Full=Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Short=Acetyl-CoA:lyso-PAF acetyltransferase; Short=Lyso-PAF acetyltransferase; Short=LysoPAFAT; AltName: Full=Acyltransferase-like 2; AltName: Full=Phosphonoformate immuno-associated protein 3; FUNCTION: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. CATALYTIC ACTIVITY: Acetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine. ENZYME REGULATION: Not activated by inflammatory stimulation. Inhibited by Cu(2+) and Fe(2+). Activity is not affected by Co(2+), Mg(2+) or Mn(2+) (By similarity). PATHWAY: Lipid metabolism; phospholipid metabolism. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine (By similarity). DOMAIN: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity). SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. SIMILARITY: Contains 2 EF-hand domains. SEQUENCE CAUTION: Sequence=BAB14061.1; Type=Erroneous initiation; Sequence=BAB14065.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NF37
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006644 phospholipid metabolic process GO:0006654 phosphatidic acid biosynthetic process GO:0006656 phosphatidylcholine biosynthetic process GO:0008152 metabolic process GO:0008654 phospholipid biosynthetic process GO:0036148 phosphatidylglycerol acyl-chain remodeling GO:0036151 phosphatidylcholine acyl-chain remodeling GO:0043129 surfactant homeostasis GO:0043312 neutrophil degranulation GO:0045732 positive regulation of protein catabolic process GO:0060041 retina development in camera-type eye GO:2001246 negative regulation of phosphatidylcholine biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
