Human Gene KLHL23 (ENST00000272797.8_3) from GENCODE V47lift37
  Description: PHOSPHO2-KLHL23 readthrough, transcript variant 1 (from RefSeq NM_001199290.3)
Gencode Transcript: ENST00000272797.8_3
Gencode Gene: ENSG00000213160.10_11
Transcript (Including UTRs)
   Position: hg19 chr2:170,551,001-170,606,314 Size: 55,314 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr2:170,591,525-170,606,242 Size: 14,718 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:170,551,001-170,606,314)mRNA (may differ from genome)Protein (558 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLH23_HUMAN
DESCRIPTION: RecName: Full=Kelch-like protein 23;
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 6 Kelch repeats.
SEQUENCE CAUTION: Sequence=BAC04490.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.47 RPKM in Colon - Sigmoid
Total median expression: 191.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -103.10338-0.305 Picture PostScript Text
3' UTR -9.7072-0.135 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR017096 - Kelch-like_gigaxonin
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13418 - Galactose oxidase, central domain
PF13964 - Kelch motif

SCOP Domains:
117281 - Kelch motif
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50985 - RCC1/BLIP-II
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
82171 - DPP6 N-terminal domain-like
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q8NBE8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0016567 protein ubiquitination

Cellular Component:
GO:0031463 Cul3-RING ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  AK314915 - Homo sapiens cDNA, FLJ95823.
LF383696 - JP 2014500723-A/191199: Polycomb-Associated Non-Coding RNAs.
BC106013 - Homo sapiens phosphatase, orphan 2, mRNA (cDNA clone MGC:111048 IMAGE:4387304), complete cds.
AK090653 - Homo sapiens cDNA FLJ33334 fis, clone BRACE2000733, weakly similar to RING CANAL PROTEIN.
AX746559 - Sequence 84 from Patent EP1308459.
BC022324 - Homo sapiens phosphatase, orphan 2, mRNA (cDNA clone MGC:22679 IMAGE:4701753), complete cds.
AX721220 - Sequence 180 from Patent WO0220754.
BC010437 - Homo sapiens kelch-like 23 (Drosophila), mRNA (cDNA clone MGC:2610 IMAGE:3354344), complete cds.
KJ900285 - Synthetic construct Homo sapiens clone ccsbBroadEn_09679 KLHL23 gene, encodes complete protein.
HQ257998 - Synthetic construct Homo sapiens clone IMAGE:100072307 kelch-like 23 (Drosophila) (KLHL23) (KLHL23) gene, encodes complete protein.
AK095131 - Homo sapiens cDNA FLJ37812 fis, clone BRSSN2002160, weakly similar to RING CANAL PROTEIN.
BC016950 - Homo sapiens kelch-like 23 (Drosophila), mRNA (cDNA clone IMAGE:3854163), complete cds.
MA619273 - JP 2018138019-A/191199: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000272797.1, ENST00000272797.2, ENST00000272797.3, ENST00000272797.4, ENST00000272797.5, ENST00000272797.6, ENST00000272797.7, KLH23_HUMAN, NM_001199290, Q8N9B9, Q8NBE8, Q96FT8, uc317izx.1, uc317izx.2
UCSC ID: ENST00000272797.8_3
RefSeq Accession: NM_001199290.3
Protein: Q8NBE8 (aka KLH23_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.