ID:KI18B_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF18B; FUNCTION: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. SUBUNIT: Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase. TISSUE SPECIFICITY: Shows a prominent expression in the amygdala. DEVELOPMENTAL STAGE: Regulated in a cell cycle-dependent manner. Not expressed in the G1 phase. In G2, sequestered in the nucleus. Maximal levels seen at late G2/M phase and early prometaphase. Degraded at the metaphase-anaphase transition (at protein level). SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAI36591.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI44272.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86Y91
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
DQ595941 - Homo sapiens piRNA piR-62053, complete sequence. BC048263 - Homo sapiens hypothetical protein LOC146909, mRNA (cDNA clone IMAGE:4418755), partial cds. BC067365 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone IMAGE:4587138), partial cds. BC044933 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone IMAGE:4540326), partial cds. JD545858 - Sequence 526882 from Patent EP1572962. JD178308 - Sequence 159332 from Patent EP1572962. JD318087 - Sequence 299111 from Patent EP1572962. JD275836 - Sequence 256860 from Patent EP1572962. JD474290 - Sequence 455314 from Patent EP1572962. JD125376 - Sequence 106400 from Patent EP1572962. JD119379 - Sequence 100403 from Patent EP1572962. JD196972 - Sequence 177996 from Patent EP1572962. JD116533 - Sequence 97557 from Patent EP1572962. JD285474 - Sequence 266498 from Patent EP1572962. JD272333 - Sequence 253357 from Patent EP1572962. JD064306 - Sequence 45330 from Patent EP1572962. JD237803 - Sequence 218827 from Patent EP1572962. JD285420 - Sequence 266444 from Patent EP1572962. JD285419 - Sequence 266443 from Patent EP1572962. JD072212 - Sequence 53236 from Patent EP1572962. JD499753 - Sequence 480777 from Patent EP1572962. JD426771 - Sequence 407795 from Patent EP1572962. JD489177 - Sequence 470201 from Patent EP1572962. JD374550 - Sequence 355574 from Patent EP1572962. JD489176 - Sequence 470200 from Patent EP1572962. JD409296 - Sequence 390320 from Patent EP1572962. JD321969 - Sequence 302993 from Patent EP1572962. JD515264 - Sequence 496288 from Patent EP1572962. JD119360 - Sequence 100384 from Patent EP1572962. JD301281 - Sequence 282305 from Patent EP1572962. JD288702 - Sequence 269726 from Patent EP1572962. JD160624 - Sequence 141648 from Patent EP1572962. JD273155 - Sequence 254179 from Patent EP1572962. JD173056 - Sequence 154080 from Patent EP1572962. JD203446 - Sequence 184470 from Patent EP1572962. BC136590 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone MGC:168203 IMAGE:9020580), complete cds. BC144271 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone MGC:177808 IMAGE:9052791), complete cds. JD220599 - Sequence 201623 from Patent EP1572962. JD111120 - Sequence 92144 from Patent EP1572962. GU808359 - Homo sapiens cell-line HeLa KIF18B mRNA, complete cds. JD065058 - Sequence 46082 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q86Y91 (Reactome details) participates in the following event(s):
R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-983189 Kinesins R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-109582 Hemostasis R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
