Human Gene IRF7 (ENST00000525445.6_11) from GENCODE V47lift37
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: IRF7_HUMAN
DESCRIPTION: RecName: Full=Interferon regulatory factor 7; Short=IRF-7;
FUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. ENZYME REGULATION: In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA- binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes. SUBUNIT: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome- dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6. INTERACTION: O00170:AIP; NbExp=2; IntAct=EBI-968267, EBI-704197; P10398:ARAF; NbExp=2; IntAct=EBI-968267, EBI-365961; Q96A33:CCDC47; NbExp=2; IntAct=EBI-968267, EBI-720151; P51617:IRAK1; NbExp=2; IntAct=EBI-968267, EBI-358664; O94822:LTN1; NbExp=2; IntAct=EBI-968267, EBI-1044684; Q9ULE6:PALD; NbExp=2; IntAct=EBI-968267, EBI-3957166; Q86UE8:TLK2; NbExp=2; IntAct=EBI-968267, EBI-1047967; Q9BVS5:TRMT61B; NbExp=2; IntAct=EBI-968267, EBI-3197877; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus. TISSUE SPECIFICITY: Expressed predominantly in spleen, thymus and peripheral blood leukocytes. INDUCTION: By type I interferon (IFN) and viruses. PTM: Acetylation inhibits its DNA-binding ability and activity. PTM: In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1. PTM: TRAF6-mediated ubiquitination is required for IRF7 activation (By similarity). PTM: Sumoylated by TRIM28, which inhibits its transactivation activity. SIMILARITY: Belongs to the IRF family. SIMILARITY: Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
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Primer design for this transcript
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MalaCards Disease Associations
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MalaCards Gene Search: IRF7
Diseases sorted by gene-association score: immunodeficiency 39* (1278), venezuelan equine encephalitis (16), vaccinia (15), influenza (13), hepatitis c (13), yellow fever (13), avian influenza (11), kaposi sarcoma (10), pediatric lymphoma (9), viral infectious disease (8), eczema herpeticum (8), hepatitis c virus (3) * = Manually curated disease association
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Comparative Toxicogenomics Database (CTD)
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR019817 - Interferon_reg_fac_CS
IPR001346 - Interferon_reg_fact_DNA-bd_dom
IPR019471 - Interferon_reg_factor-3
IPR017855 - SMAD_dom-like
IPR008984 - SMAD_FHA_domain
IPR011991 - WHTH_trsnscrt_rep_DNA-bd
Pfam Domains: PF00605 - Interferon regulatory factor transcription factor
PF10401 - Interferon-regulatory factor 3
SCOP Domains: 46785 - "Winged helix" DNA-binding domain
49879 - SMAD/FHA domain
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q92985
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Molecular Function: GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002376 immune system process
GO:0002819 regulation of adaptive immune response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0009615 response to virus
GO:0016032 viral process
GO:0016064 immunoglobulin mediated immune response
GO:0019043 establishment of viral latency
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032607 interferon-alpha production
GO:0032608 interferon-beta production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0039530 MDA-5 signaling pathway
GO:0045087 innate immune response
GO:0045351 type I interferon biosynthetic process
GO:0045655 regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050776 regulation of immune response
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:2000110 negative regulation of macrophage apoptotic process
Cellular Component: GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010008 endosome membrane
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Descriptions from all associated GenBank mRNAs
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LF207967 - JP 2014500723-A/15470: Polycomb-Associated Non-Coding RNAs. KC477210 - Homo sapiens interferon regulatory factor 7 transcript variant e (IRF7) mRNA, complete cds, alternatively spliced. U53831 - Homo sapiens interferon regulatory factor 7B mRNA, complete cds. U53830 - Homo sapiens interferon regulatory factor 7A mRNA, complete cds. AK303752 - Homo sapiens cDNA FLJ61529 complete cds, highly similar to Interferon regulatory factor 7. U53832 - Homo sapiens interferon regulatory factor 7C mRNA, complete cds. AF076494 - Homo sapiens interferon regulatory factor 7H (IRF7) mRNA, alternatively spliced, complete cds. BC136555 - Homo sapiens interferon regulatory factor 7, mRNA (cDNA clone MGC:168168 IMAGE:9020545), complete cds. BC144242 - Homo sapiens cDNA clone IMAGE:9052762, with apparent retained intron. U73036 - Human interferon regulatory factor 7 (humirf7) mRNA, complete cds. KX150851 - Homo sapiens cell-line HEK293T interferon regulatory factor 7G isoform mRNA, complete cds. AB463790 - Synthetic construct DNA, clone: pF1KB9738, Homo sapiens IRF7 gene for interferon regulatory factor 7, without stop codon, in Flexi system. JD068367 - Sequence 49391 from Patent EP1572962. JD186838 - Sequence 167862 from Patent EP1572962. JD182096 - Sequence 163120 from Patent EP1572962. JD206615 - Sequence 187639 from Patent EP1572962. JD187487 - Sequence 168511 from Patent EP1572962. JD404690 - Sequence 385714 from Patent EP1572962. JD343552 - Sequence 324576 from Patent EP1572962. LF370559 - JP 2014500723-A/178062: Polycomb-Associated Non-Coding RNAs. JD213730 - Sequence 194754 from Patent EP1572962. JD483306 - Sequence 464330 from Patent EP1572962. JD051024 - Sequence 32048 from Patent EP1572962. JD423999 - Sequence 405023 from Patent EP1572962. JD191431 - Sequence 172455 from Patent EP1572962. JD104568 - Sequence 85592 from Patent EP1572962. JD115805 - Sequence 96829 from Patent EP1572962. JD190298 - Sequence 171322 from Patent EP1572962. JD417010 - Sequence 398034 from Patent EP1572962. JD341641 - Sequence 322665 from Patent EP1572962. JD435655 - Sequence 416679 from Patent EP1572962. JD439087 - Sequence 420111 from Patent EP1572962. JD329374 - Sequence 310398 from Patent EP1572962. JD098020 - Sequence 79044 from Patent EP1572962. JD114928 - Sequence 95952 from Patent EP1572962. LF370560 - JP 2014500723-A/178063: Polycomb-Associated Non-Coding RNAs. JD199942 - Sequence 180966 from Patent EP1572962. JD129659 - Sequence 110683 from Patent EP1572962. JD056273 - Sequence 37297 from Patent EP1572962. JD307377 - Sequence 288401 from Patent EP1572962. JD483440 - Sequence 464464 from Patent EP1572962. LF370562 - JP 2014500723-A/178065: Polycomb-Associated Non-Coding RNAs. LF370564 - JP 2014500723-A/178067: Polycomb-Associated Non-Coding RNAs. JD469924 - Sequence 450948 from Patent EP1572962. JD390734 - Sequence 371758 from Patent EP1572962. JD076097 - Sequence 57121 from Patent EP1572962. MA606136 - JP 2018138019-A/178062: Polycomb-Associated Non-Coding RNAs. MA606137 - JP 2018138019-A/178063: Polycomb-Associated Non-Coding RNAs. MA606139 - JP 2018138019-A/178065: Polycomb-Associated Non-Coding RNAs. MA606141 - JP 2018138019-A/178067: Polycomb-Associated Non-Coding RNAs. MA443544 - JP 2018138019-A/15470: Polycomb-Associated Non-Coding RNAs.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: B9EGL3, ENST00000525445.1, ENST00000525445.2, ENST00000525445.3, ENST00000525445.4, ENST00000525445.5, IRF7_HUMAN, NM_001572, O00331, O00332, O00333, O75924, Q92985, Q9UE79, uc324apn.1, uc324apn.2 UCSC ID: ENST00000525445.6_11 RefSeq Accession: NM_001572.5
Protein: Q92985
(aka IRF7_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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