ID:IL7_HUMAN DESCRIPTION: RecName: Full=Interleukin-7; Short=IL-7; Flags: Precursor; FUNCTION: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. INTERACTION: P31785:IL2RG; NbExp=2; IntAct=EBI-80516, EBI-80475; P16871:IL7R; NbExp=3; IntAct=EBI-80516, EBI-80490; SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the IL-7/IL-9 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-7 entry; URL="http://en.wikipedia.org/wiki/Interleukin_7";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13232
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002360 T cell lineage commitment GO:0006955 immune response GO:0006959 humoral immune response GO:0007267 cell-cell signaling GO:0008284 positive regulation of cell proliferation GO:0009887 animal organ morphogenesis GO:0010468 regulation of gene expression GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0030890 positive regulation of B cell proliferation GO:0032722 positive regulation of chemokine production GO:0038111 interleukin-7-mediated signaling pathway GO:0043066 negative regulation of apoptotic process GO:0043086 negative regulation of catalytic activity GO:0045453 bone resorption GO:0045582 positive regulation of T cell differentiation GO:0046622 positive regulation of organ growth GO:0048873 homeostasis of number of cells within a tissue GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
BC047698 - Homo sapiens interleukin 7, mRNA (cDNA clone MGC:51943 IMAGE:5748841), complete cds. BC032487 - Homo sapiens interleukin 7, mRNA (cDNA clone IMAGE:5220028), containing frame-shift errors. J04156 - Human interleukin 7 (IL-7) mRNA, complete cds. AK226000 - Homo sapiens mRNA for interleukin 7 precursor variant, clone: FCC109E12. AK291538 - Homo sapiens cDNA FLJ75417 complete cds, highly similar to Homo sapiens interleukin 7, mRNA. GQ919059 - Homo sapiens interleukin 7 (IL7) mRNA, partial cds. KX160446 - Homo sapiens interleukin 7 mRNA, partial cds. AB102879 - Homo sapiens mRNA for IL7 nirs variant 2, complete cds. AB102893 - Homo sapiens mRNA for IL7 nirs variant 1, complete cds. KJ891458 - Synthetic construct Homo sapiens clone ccsbBroadEn_00852 IL7 gene, encodes complete protein. AB587431 - Synthetic construct DNA, clone: pF1KB6851, Homo sapiens IL7 gene for interleukin 7, without stop codon, in Flexi system. CU690462 - Synthetic construct Homo sapiens gateway clone IMAGE:100021291 5' read IL7 mRNA. AB102882 - Homo sapiens mRNA for IL7 nirs variant 3, complete cds. AB102885 - Homo sapiens mRNA for IL7 nirs variant 6, complete cds. JD305960 - Sequence 286984 from Patent EP1572962. JD313067 - Sequence 294091 from Patent EP1572962. JD044085 - Sequence 25109 from Patent EP1572962. JD296188 - Sequence 277212 from Patent EP1572962. JD171866 - Sequence 152890 from Patent EP1572962. AB102883 - Homo sapiens mRNA for IL7 nirs variant 4, complete cds. AB102880 - Homo sapiens mRNA for IL7 nirs variant 5, complete cds. JD325352 - Sequence 306376 from Patent EP1572962. JD336411 - Sequence 317435 from Patent EP1572962. JD068819 - Sequence 49843 from Patent EP1572962. JD462835 - Sequence 443859 from Patent EP1572962. JD559779 - Sequence 540803 from Patent EP1572962. JD250196 - Sequence 231220 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_il7Pathway - IL-7 Signal Transduction h_stemPathway - Regulation of hematopoiesis by cytokines h_inflamPathway - Cytokines and Inflammatory Response
Reactome (by CSHL, EBI, and GO)
Protein P13232 (Reactome details) participates in the following event(s):
R-HSA-449978 IL7 binds IL7R:JAK1 R-HSA-1266684 IL7 binds HGF(495-728) to form PPBSF R-NUL-1266699 PPBSF is a complex of Il7 and Hgf(495-728) R-HSA-449958 IL7:IL7R:JAK1 binds IL2RG:JAK3 R-HSA-1295519 IL7R is phosphorylated on Y499 R-HSA-1295516 IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits R-HSA-6785165 p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B R-HSA-1266695 Interleukin-7 signaling R-HSA-449147 Signaling by Interleukins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
