Human Gene IL5 (ENST00000231454.6_7) from GENCODE V47lift37
  Description: interleukin 5 (from RefSeq NM_000879.3)
Gencode Transcript: ENST00000231454.6_7
Gencode Gene: ENSG00000113525.10_12
Transcript (Including UTRs)
   Position: hg19 chr5:131,877,137-131,879,214 Size: 2,078 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr5:131,877,503-131,879,170 Size: 1,668 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:131,877,137-131,879,214)mRNA (may differ from genome)Protein (134 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL5_HUMAN
DESCRIPTION: RecName: Full=Interleukin-5; Short=IL-5; AltName: Full=B-cell differentiation factor I; AltName: Full=Eosinophil differentiation factor; AltName: Full=T-cell replacing factor; Short=TRF; Flags: Precursor;
FUNCTION: Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.
SUBUNIT: Homodimer; disulfide-linked.
INTERACTION: P32927:CSF2RB; NbExp=2; IntAct=EBI-2435811, EBI-1809771; Q01344:IL5RA; NbExp=2; IntAct=EBI-2435811, EBI-1759442;
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the IL-5 family.
WEB RESOURCE: Name=R&D Systems' cytokine mini-reviews: IL-5; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1646";
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-5 entry; URL="http://en.wikipedia.org/wiki/Interleukin_5";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il5/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL5
Diseases sorted by gene-association score: pulmonary eosinophilia (35), chronic eosinophilic pneumonia (34), eosinophilic pneumonia (34), eosinophilia-myalgia syndrome (30), filariasis (30), paragonimiasis (29), hypereosinophilic syndrome (29), allergic hypersensitivity disease (28), strongyloidiasis (27), allergic asthma (26), rhinitis (26), allergic rhinitis (24), paranasal sinus disease (24), parasitic helminthiasis infectious disease (23), eosinophilic gastritis (23), eosinophilic gastroenteritis (22), ascariasis (22), schistosomiasis (22), cellulitis (22), kimura disease (22), necatoriasis (22), onchocerciasis (21), allergic contact dermatitis (21), intrinsic asthma (20), leukocyte disease (19), asthma (18), churg-strauss syndrome (18), food allergy (18), granulomatous angiitis (18), esophagitis (18), eosinophilic meningitis (16), pollen allergy (16), contact dermatitis (16), cough variant asthma (16), keratoconjunctivitis (16), urinary schistosomiasis (16), latex allergy (16), respiratory syncytial virus infectious disease (15), allergic bronchopulmonary aspergillosis (15), intestinal schistosomiasis (15), milk allergy (14), allergic conjunctivitis (13), cutaneous leishmaniasis (13), cow milk allergy (13), toxic oil syndrome (12), atopy (12), cytokine deficiency (12), scleritis (12), vernal keratoconjunctivitis (12), sinusitis (12), respiratory system disease (11), bronchiolitis (11), hypereosinophilic syndrome, idiopathic, resistant to imatinib (11), folliculitis (11), status asthmaticus (11), angioimmunoblastic lymphadenopathy with dysproteinemia (11), mansonelliasis (10), bronchitis (10), atopic keratoconjunctivitis (10), gastroenteritis (10), bronchial disease (10), angiostrongyliasis (10), yellow fever (10), atopic dermatitis (9), tetanus (9), upper respiratory tract disease (9), egg allergy (9), pemphigoid gestationis (9), bullous pemphigoid (9), bullous skin disease (9), gastrointestinal allergy (9), esophagitis, eosinophilic, 1 (9), conjunctivitis (9), bagassosis (8), seborrheic infantile dermatitis (8), omenn syndrome (8), nose disease (8), nasal cavity disease (8), eosinophilic fasciitis (8), multicentric castleman disease (8), leishmaniasis (8), relapsing polychondritis (7), paracoccidioidomycosis (7), echinococcosis (7), radiculopathy (7), mycosis fungoides (7), chronic meningitis (7), angioedema (7), aspergillosis (7), chronic conjunctivitis (7), cardiac sarcoidosis (7), nut allergy (6), stevens-johnson syndrome/toxic epidermal necrolysis (6), loeffler endocarditis (6), esophageal disease (6), wells syndrome (6), sezary's disease (6), pustulosis palmaris et plantaris (6), gastroesophageal reflux (6), trichinosis (5), common cold (5), mast cell disease (5), non-suppurative otitis media (5), autoinflammation, lipodystrophy, and dermatosis syndrome (5), immune system disease (5), apple allergy (5), night blindness, congenital stationary , 1a, x-linked (5), intestinal volvulus (5), inflammatory bowel disease 4 (5), dermatitis (5), enterobiasis (5), anterior scleritis (4), conjunctival disease (4), chronic tic disorder (4), cercarial dermatitis (4), norwegian scabies (4), pneumonia (4), primary amebic meningoencephalitis (4), radiation cystitis (4), mesenteric lymphadenitis (4), lung disease (3), malaria (2), eye disease (2), hypersensitivity reaction disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.83 RPKM in Testis
Total median expression: 4.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.2044-0.141 Picture PostScript Text
3' UTR -70.70366-0.193 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR000186 - Interleukin_5

Pfam Domains:
PF02025 - Interleukin 5

SCOP Domains:
47266 - 4-helical cytokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1HUL - X-ray MuPIT 3QT2 - X-ray MuPIT 3VA2 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P05113
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004713 protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005125 cytokine activity
GO:0005137 interleukin-5 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity

Biological Process:
GO:0000165 MAPK cascade
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0045645 positive regulation of eosinophil differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046427 positive regulation of JAK-STAT cascade
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0071803 positive regulation of podosome assembly

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  DQ655971 - Homo sapiens clone UGL8g04, mRNA sequence.
BC069137 - Homo sapiens cDNA clone IMAGE:7216996, containing frame-shift errors.
E01639 - cDNA encoding human B cell differentiation Factor.
X04688 - Human mRNA for T-cell replacing factor (interleukin-5).
X12705 - H.sapiens mRNA for B cell differentiation factor I.
JD047365 - Sequence 28389 from Patent EP1572962.
JD069004 - Sequence 50028 from Patent EP1572962.
JD062579 - Sequence 43603 from Patent EP1572962.
BC066279 - Homo sapiens cDNA clone IMAGE:6971768, containing frame-shift errors.
BC066280 - Homo sapiens cDNA clone IMAGE:6971769, containing frame-shift errors.
BC066281 - Homo sapiens cDNA clone IMAGE:6971770, containing frame-shift errors.
BC066282 - Homo sapiens interleukin 5 (colony-stimulating factor, eosinophil), mRNA (cDNA clone MGC:79409 IMAGE:6971771), complete cds.
FU768456 - Short interference ribonucleic acids for treating allergic diseases.
KJ897045 - Synthetic construct Homo sapiens clone ccsbBroadEn_06439 IL5 gene, encodes complete protein.
AB591005 - Synthetic construct DNA, clone: pFN21AB6718, Homo sapiens IL5 gene for interleukin 5, without stop codon, in Flexi system.
FU768455 - Short interference ribonucleic acids for treating allergic diseases.
DQ655974 - Homo sapiens clone UGL8e03, mRNA sequence.
FU768454 - Short interference ribonucleic acids for treating allergic diseases.
JD208142 - Sequence 189166 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_nktPathway - Selective expression of chemokine receptors during T-cell polarization
h_stemPathway - Regulation of hematopoiesis by cytokines
h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy
h_il5Pathway - IL 5 Signaling Pathway
h_inflamPathway - Cytokines and Inflammatory Response
h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression
h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development
h_cytokinePathway - Cytokine Network

Reactome (by CSHL, EBI, and GO)

Protein P05113 (Reactome details) participates in the following event(s):

R-HSA-913446 Interleukin-5 is a homodimer
R-HSA-913456 Interleukin-5 receptor alpha subunit binds Interleukin-5
R-HSA-913370 Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
R-HSA-879934 Recruitment of SHC1 is mediated by Y593 of the common beta chain
R-HSA-909738 SHP1 and SHP2 bind the common beta chain
R-HSA-879907 Tyrosine kinases phosphorylate the receptor
R-HSA-879930 STAT5 is recruited by JAK2
R-HSA-879910 JAK2 is phosphorylated, activated
R-HSA-921155 p-STAT5 dissociates from the receptor complex
R-HSA-913451 IL3RB is phosphorylated on Ser-585
R-HSA-912757 p-S585-IL3RB binds 14-3-3 proteins
R-HSA-879925 SHC1 bound to the common beta chain becomes tyrosine phosphorylated
R-HSA-914036 SHP1 and SHP2 dephosphorylate Y628 of IL3RB
R-HSA-879909 Activation of STAT5a/b by JAK2
R-HSA-914182 14-3-3 zeta binding allows recruitment of PI3K
R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1
R-HSA-913374 Phosphorylated SHC1 recruits SHIP
R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases
R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000231454.1, ENST00000231454.2, ENST00000231454.3, ENST00000231454.4, ENST00000231454.5, IL5_HUMAN, NM_000879, P05113, Q13840, uc317dul.1, uc317dul.2
UCSC ID: ENST00000231454.6_7
RefSeq Accession: NM_000879.3
Protein: P05113 (aka IL5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.