ID:IL12A_HUMAN DESCRIPTION: RecName: Full=Interleukin-12 subunit alpha; Short=IL-12A; AltName: Full=Cytotoxic lymphocyte maturation factor 35 kDa subunit; Short=CLMF p35; AltName: Full=IL-12 subunit p35; AltName: Full=NK cell stimulatory factor chain 1; Short=NKSF1; Flags: Precursor; FUNCTION: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. SUBUNIT: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12. INTERACTION: P29460:IL12B; NbExp=2; IntAct=EBI-1029636, EBI-1029614; SUBCELLULAR LOCATION: Secreted. INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection. SIMILARITY: Belongs to the IL-6 superfamily. SEQUENCE CAUTION: Sequence=AAA59937.1; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-12 entry; URL="http://en.wikipedia.org/wiki/Interleukin_12"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il12a/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P29459
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_th1th2Pathway - Th1/Th2 Differentiation
Reactome (by CSHL, EBI, and GO)
Protein P29459 (Reactome details) participates in the following event(s):
R-HSA-447226 Interleukin-12 binds Interleukin-12 receptor R-HSA-8950128 Interleukin-12 dissociates from Interleukin-12 receptor R-HSA-8950347 IL12A:IL12B translocates from late endosome lumen to extracellular region R-HSA-8950752 IL12A:IL12B translocates from Golgi lumen to late endosome lumen R-HSA-8950423 JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated R-HSA-8950448 STAT4 binds to IL12RB2 in Interleukin-12 receptor complex R-HSA-9020591 Interleukin-12 signaling R-HSA-8984722 Interleukin-35 Signalling R-HSA-6783783 Interleukin-10 signaling R-HSA-447115 Interleukin-12 family signaling R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-449147 Signaling by Interleukins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
