Human Gene IGF2 (ENST00000416167.7_14) from GENCODE V47lift37
  Description: insulin like growth factor 2, transcript variant 1 (from RefSeq NM_000612.6)
Gencode Transcript: ENST00000416167.7_14
Gencode Gene: ENSG00000167244.22_21
Transcript (Including UTRs)
   Position: hg19 chr11:2,150,347-2,160,619 Size: 10,273 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr11:2,154,217-2,156,753 Size: 2,537 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:2,150,347-2,160,619)mRNA (may differ from genome)Protein (180 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IGF2_HUMAN
DESCRIPTION: RecName: Full=Insulin-like growth factor II; Short=IGF-II; AltName: Full=Somatomedin-A; Contains: RecName: Full=Insulin-like growth factor II; Contains: RecName: Full=Insulin-like growth factor II Ala-25 Del; Contains: RecName: Full=Preptin; Flags: Precursor;
FUNCTION: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
SUBCELLULAR LOCATION: Secreted.
PTM: O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.
MASS SPECTROMETRY: Mass=7469.4; Method=MALDI; Range=25-91; Source=PubMed:12586351, PubMed:15359740;
MASS SPECTROMETRY: Mass=7398.3; Method=MALDI; Range=26-91; Source=PubMed:12586351, PubMed:15359740;
POLYMORPHISM: Genetic variations in IGF2 are associated with body mass index (BMI). The BMI is a statistical measurement which compares a person's weight and height.
DISEASE: Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:180860]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.
SIMILARITY: Belongs to the insulin family.
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IGF2";
WEB RESOURCE: Name=Wikipedia; Note=Insulin-like growth factor 2 entry; URL="http://en.wikipedia.org/wiki/Insulin-like_growth_factor_2";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/igf2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IGF2
Diseases sorted by gene-association score: growth restriction, severe, with distinctive facies* (969), silver-russell syndrome* (548), silver-russell syndrome due to a point mutation* (350), hemihyperplasia, isolated* (247), chromosome 11p15.5-related russell-silver syndrome* (100), silver-russell syndrome due to an imprinting defect of 11p15* (25), silver-russell syndrome due to 11p15 microduplication* (25), beckwith-wiedemann syndrome (19), adrenal carcinoma (19), choroid plexus papilloma (18), beckwith-wiedemann syndrome due to imprinting defect of 11p15* (18), breast cancer, childhood (17), congenital mesoblastic nephroma (15), osteochondrosis (15), rhabdomyosarcoma (15), hepatoblastoma (15), bladder leiomyoma (15), hypoglycemic coma (15), fetal macrosomia (13), mucopolysaccharidosis type iiib (13), hemangiopericytoma, malignant (13), potter's syndrome (12), hypoglycemia (12), meninges hemangiopericytoma (11), uterine fibroid (11), islet cell tumor (11), wilms tumor susceptibility-5 (10), adrenal cortical carcinoma (10), embryonal rhabdomyosarcoma (10), clear cell sarcoma (10), blastoma (9), hyperinsulinemic hypoglycemia (9), diabetes mellitus, insulin-dependent, 2 (9), proteus syndrome, somatic (9), laron dwarfism (9), rhabdoid cancer (9), diabetes mellitus, insulin-dependent, 3 (9), skeletal muscle cancer (8), bladder benign neoplasm (8), umbilical hernia (8), benign mesenchymoma (7), insulin-like growth factor i (7), hypomelanosis of ito (7), acromegaly (7), small intestine leiomyosarcoma (7), meninges sarcoma (7), small intestinal sarcoma (7), gastric leiomyosarcoma (7), frozen shoulder (7), leiomyosarcoma (7), complete androgen insensitivity syndrome (7), seminoma (7), atypical teratoid rhabdoid tumor (6), leiomyoma (6), papilloma (6), breast cancer (6), fasting hypoglycemia (6), endocrine pancreas disease (6), silver spastic paraplegia syndrome (6), wilson-turner syndrome (6), hemihypertrophy (5), hyperostosis, endosteal (5), orbital cyst (5), periosteal osteogenic sarcoma (5), cerebral neuroblastoma (5), phyllode tumor (5), acinar cell carcinoma (5), hereditary wilms' tumor (5), colorectal cancer (5), pseudopapilledema (5), ocular hyperemia (5), embryonal carcinoma (5), fetal alcohol spectrum disorder (5), iris disease (4), adult syndrome (4), hallermann-streiff syndrome (4), spinal canal and spinal cord meningioma (4), spinal meningioma (4), rubeosis iridis (4), congenital muscular dystrophy due to lmna mutation (4), juxtacortical osteosarcoma (4), hepatocellular carcinoma (3), prostate cancer (2), medulloblastoma (2), obesity (2), osteosarcoma, somatic (2), ewing sarcoma (2), gastrointestinal stromal tumor (2), stomach cancer (2), diabetes mellitus, insulin-dependent (2), meningioma, familial (2), eye disease (2), pancreas disease (2), muscle cancer (1), gastrointestinal system cancer (1), diabetes mellitus, noninsulin-dependent (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.68 RPKM in Cervix - Endocervix
Total median expression: 37.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -438.281167-0.376 Picture PostScript Text
3' UTR -1361.803870-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022334 - IGF2
IPR013576 - IGF2_C
IPR016179 - Insulin-like
IPR022350 - Insulin-like_growth_factor
IPR022353 - Insulin_CS
IPR022352 - Insulin_family

Pfam Domains:
PF00049 - Insulin/IGF/Relaxin family
PF08365 - Insulin-like growth factor II E-peptide

SCOP Domains:
56994 - Insulin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1GF2 - Model 1IGL - NMR MuPIT 2L29 - NMR MuPIT 2V5P - X-ray MuPIT 3E4Z - X-ray MuPIT 3KR3 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P01344
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005178 integrin binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0048018 receptor agonist activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001892 embryonic placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0002576 platelet degranulation
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010469 regulation of receptor activity
GO:0031017 exocrine pancreas development
GO:0031056 regulation of histone modification
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0044267 cellular protein metabolic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060669 embryonic placenta morphogenesis
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:2000467 positive regulation of glycogen (starch) synthase activity

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen


-  Descriptions from all associated GenBank mRNAs
  LF205115 - JP 2014500723-A/12618: Polycomb-Associated Non-Coding RNAs.
LF207985 - JP 2014500723-A/15488: Polycomb-Associated Non-Coding RNAs.
BC011786 - Homo sapiens insulin-like growth factor 2 (somatomedin A), mRNA (cDNA clone IMAGE:4100006).
BC073756 - Homo sapiens cDNA clone IMAGE:4123567, partial cds.
BC042127 - Homo sapiens insulin-like growth factor 2 (somatomedin A), mRNA (cDNA clone IMAGE:4123447).
AF318382 - Homo sapiens pp9974 mRNA, complete cds.
AK025719 - Homo sapiens cDNA: FLJ22066 fis, clone HEP10611.
LF370721 - JP 2014500723-A/178224: Polycomb-Associated Non-Coding RNAs.
LF207987 - JP 2014500723-A/15490: Polycomb-Associated Non-Coding RNAs.
JD487578 - Sequence 468602 from Patent EP1572962.
JD390777 - Sequence 371801 from Patent EP1572962.
AY971350 - Homo sapiens cell growth-inhibiting protein 44 mRNA, complete cds.
KJ901508 - Synthetic construct Homo sapiens clone ccsbBroadEn_10902 IGF2 gene, encodes complete protein.
LF370722 - JP 2014500723-A/178225: Polycomb-Associated Non-Coding RNAs.
JD035981 - Sequence 17005 from Patent EP1572962.
JD019672 - Sequence 696 from Patent EP1572962.
LF370723 - JP 2014500723-A/178226: Polycomb-Associated Non-Coding RNAs.
JD479855 - Sequence 460879 from Patent EP1572962.
JD384837 - Sequence 365861 from Patent EP1572962.
LF370724 - JP 2014500723-A/178227: Polycomb-Associated Non-Coding RNAs.
JD027314 - Sequence 8338 from Patent EP1572962.
JD023052 - Sequence 4076 from Patent EP1572962.
JD366035 - Sequence 347059 from Patent EP1572962.
JD035723 - Sequence 16747 from Patent EP1572962.
JD021903 - Sequence 2927 from Patent EP1572962.
JD024039 - Sequence 5063 from Patent EP1572962.
JD024040 - Sequence 5064 from Patent EP1572962.
JD026387 - Sequence 7411 from Patent EP1572962.
JD028983 - Sequence 10007 from Patent EP1572962.
LF370726 - JP 2014500723-A/178229: Polycomb-Associated Non-Coding RNAs.
JD275876 - Sequence 256900 from Patent EP1572962.
LF370728 - JP 2014500723-A/178231: Polycomb-Associated Non-Coding RNAs.
LF370729 - JP 2014500723-A/178232: Polycomb-Associated Non-Coding RNAs.
JD022902 - Sequence 3926 from Patent EP1572962.
JD027329 - Sequence 8353 from Patent EP1572962.
JD034069 - Sequence 15093 from Patent EP1572962.
JD025057 - Sequence 6081 from Patent EP1572962.
JD035406 - Sequence 16430 from Patent EP1572962.
JD028425 - Sequence 9449 from Patent EP1572962.
LF370730 - JP 2014500723-A/178233: Polycomb-Associated Non-Coding RNAs.
DQ104203 - Homo sapiens insulin-like growth factor type 2 (IGF2) mRNA, complete cds, alternatively spliced.
DQ104205 - Homo sapiens INSIGF long transcript variant mRNA, complete cds, alternatively spliced.
LF370731 - JP 2014500723-A/178234: Polycomb-Associated Non-Coding RNAs.
LF370732 - JP 2014500723-A/178235: Polycomb-Associated Non-Coding RNAs.
S77035 - insulin-like growth factor II [human, small cell lung cancer cell line T3M-11, mRNA, 1322 nt].
BC053318 - Homo sapiens insulin-like growth factor 2 (somatomedin A), mRNA (cDNA clone IMAGE:6284227), partial cds.
AF217977 - Homo sapiens clone PP1446 unknown mRNA.
BC000531 - Homo sapiens insulin-like growth factor 2 (somatomedin A), mRNA (cDNA clone MGC:8683 IMAGE:2964584), complete cds.
AK291594 - Homo sapiens cDNA FLJ78037 complete cds, highly similar to Homo sapiens insulin-like growth factor 2 (somatomedin A), mRNA.
LF370733 - JP 2014500723-A/178236: Polycomb-Associated Non-Coding RNAs.
J03242 - Human insulin-lke growth factor II mRNA, complete cds.
M29645 - Human insulin-like growth factor II mRNA, complete cds.
X00910 - Homo sapiens mRNA for preproinsulin-like growth factor II (IGF-II), (IGF2 gene).
JD436642 - Sequence 417666 from Patent EP1572962.
JD532819 - Sequence 513843 from Patent EP1572962.
JD218204 - Sequence 199228 from Patent EP1572962.
JD256473 - Sequence 237497 from Patent EP1572962.
LF370734 - JP 2014500723-A/178237: Polycomb-Associated Non-Coding RNAs.
JD393456 - Sequence 374480 from Patent EP1572962.
X06159 - Human mRNA for insulin-like growth factor II (clone P35).
JD203708 - Sequence 184732 from Patent EP1572962.
M17863 - Human preproinsulin-like growth factor II (IGF-II) variant mRNA, complete cds.
JD141471 - Sequence 122495 from Patent EP1572962.
JD060048 - Sequence 41072 from Patent EP1572962.
JD141335 - Sequence 122359 from Patent EP1572962.
DQ892721 - Synthetic construct clone IMAGE:100005351; FLH189105.01X; RZPDo839B0874D insulin-like growth factor 2 (somatomedin A) (IGF2) gene, encodes complete protein.
DQ895970 - Synthetic construct Homo sapiens clone IMAGE:100010430; FLH189101.01L; RZPDo839B0864D insulin-like growth factor 2 (somatomedin A) (IGF2) gene, encodes complete protein.
AK313938 - Homo sapiens cDNA, FLJ94578, Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2),mRNA.
M17426 - Human prepro-insulin-like growth factor II (prepro-IGF-II) mRNA, complete cds.
KJ891442 - Synthetic construct Homo sapiens clone ccsbBroadEn_00836 IGF2 gene, encodes complete protein.
BT007013 - Homo sapiens insulin-like growth factor 2 (somatomedin A) mRNA, complete cds.
AB528666 - Synthetic construct DNA, clone: pF1KB6885, Homo sapiens IGF2 gene for insulin-like growth factor 2, without stop codon, in Flexi system.
LF370735 - JP 2014500723-A/178238: Polycomb-Associated Non-Coding RNAs.
X06160 - Homo sapiens pre-mRNA for insulin-like growth factor II precursor, clone P21.
CU674260 - Synthetic construct Homo sapiens gateway clone IMAGE:100017976 5' read IGF2 mRNA.
HM481219 - Homo sapiens insulin-like growth factor II transcript variant 3 isoform 2 (IGF2) mRNA, partial cds, alternatively spliced.
HM481220 - Homo sapiens insulin-like growth factor II transcript variant 3 isoform 1 (IGF2) mRNA, partial cds, alternatively spliced.
X06161 - Human mRNA for insulin-like growth factor II (clone P22).
LF370736 - JP 2014500723-A/178239: Polycomb-Associated Non-Coding RNAs.
S51971 - insulin-like growth factor-II {5' region} [human, placenta, mRNA Partial, 100 nt].
LF212165 - JP 2014500723-A/19668: Polycomb-Associated Non-Coding RNAs.
X06260 - Human hepatoma mRNA 5'term. for insulin-like growth factor II.
JD256450 - Sequence 237474 from Patent EP1572962.
JD334962 - Sequence 315986 from Patent EP1572962.
JD146874 - Sequence 127898 from Patent EP1572962.
JD524137 - Sequence 505161 from Patent EP1572962.
JD191035 - Sequence 172059 from Patent EP1572962.
LF370737 - JP 2014500723-A/178240: Polycomb-Associated Non-Coding RNAs.
JD161392 - Sequence 142416 from Patent EP1572962.
JD140988 - Sequence 122012 from Patent EP1572962.
JD129270 - Sequence 110294 from Patent EP1572962.
JD144222 - Sequence 125246 from Patent EP1572962.
JD457927 - Sequence 438951 from Patent EP1572962.
JD057250 - Sequence 38274 from Patent EP1572962.
LF370738 - JP 2014500723-A/178241: Polycomb-Associated Non-Coding RNAs.
LF370739 - JP 2014500723-A/178242: Polycomb-Associated Non-Coding RNAs.
LF370740 - JP 2014500723-A/178243: Polycomb-Associated Non-Coding RNAs.
MA440692 - JP 2018138019-A/12618: Polycomb-Associated Non-Coding RNAs.
MA606298 - JP 2018138019-A/178224: Polycomb-Associated Non-Coding RNAs.
MA606299 - JP 2018138019-A/178225: Polycomb-Associated Non-Coding RNAs.
MA606300 - JP 2018138019-A/178226: Polycomb-Associated Non-Coding RNAs.
MA606301 - JP 2018138019-A/178227: Polycomb-Associated Non-Coding RNAs.
MA606303 - JP 2018138019-A/178229: Polycomb-Associated Non-Coding RNAs.
MA606305 - JP 2018138019-A/178231: Polycomb-Associated Non-Coding RNAs.
MA606306 - JP 2018138019-A/178232: Polycomb-Associated Non-Coding RNAs.
MA606307 - JP 2018138019-A/178233: Polycomb-Associated Non-Coding RNAs.
MA606308 - JP 2018138019-A/178234: Polycomb-Associated Non-Coding RNAs.
MA606309 - JP 2018138019-A/178235: Polycomb-Associated Non-Coding RNAs.
MA606310 - JP 2018138019-A/178236: Polycomb-Associated Non-Coding RNAs.
MA606311 - JP 2018138019-A/178237: Polycomb-Associated Non-Coding RNAs.
MA606312 - JP 2018138019-A/178238: Polycomb-Associated Non-Coding RNAs.
MA606313 - JP 2018138019-A/178239: Polycomb-Associated Non-Coding RNAs.
MA606314 - JP 2018138019-A/178240: Polycomb-Associated Non-Coding RNAs.
MA606315 - JP 2018138019-A/178241: Polycomb-Associated Non-Coding RNAs.
MA606316 - JP 2018138019-A/178242: Polycomb-Associated Non-Coding RNAs.
MA606317 - JP 2018138019-A/178243: Polycomb-Associated Non-Coding RNAs.
MA443562 - JP 2018138019-A/15488: Polycomb-Associated Non-Coding RNAs.
MA443564 - JP 2018138019-A/15490: Polycomb-Associated Non-Coding RNAs.
MA447742 - JP 2018138019-A/19668: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P01344 (Reactome details) participates in the following event(s):

R-HSA-381412 IGFBP2 binds IGF forming IGF:IGFBP2
R-HSA-381487 IGFBP1 binds IGF forming IGF:IGFBP1
R-HSA-381496 Formation of the IGF:IGFBP3:ALS complex
R-HSA-381503 IGFBP6 binds IGF forming IGF:IGFBP6
R-HSA-381543 IGFBP4 binds IGF forming IGF:IGFBP4
R-HSA-381545 Formation of the IGF:IGFBP5:ALS complex
R-HSA-2404200 IGF1,2 binds IGF1R
R-HSA-381435 Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS
R-HSA-381446 Thrombin proteolyzes IGF:IGFBP3:ALS
R-HSA-381461 Plasmin proteolyzes IGF:IGFBP-3:ALS
R-HSA-381466 Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS
R-HSA-381500 Cathepsin G proteolyzes IGF:IGFBP3:ALS
R-HSA-381518 PAAP-A proteolyzes IGF:IGFBP4
R-HSA-381537 PAPP-A2 proteolyzes IGF:IGFBP5:ALS
R-HSA-2404199 IGF1,2:IGF1R autophosphorylates
R-HSA-2404195 IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1
R-HSA-2428922 IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2
R-HSA-2428930 IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4
R-HSA-5686072 p-3Y-SHC1 dissociates from IGF1R
R-HSA-481007 Exocytosis of platelet alpha granule contents
R-HSA-2404193 IGF1R phosphorylates SHC1
R-HSA-2428926 IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-392499 Metabolism of proteins
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-114608 Platelet degranulation
R-HSA-2428924 IGF1R signaling cascade
R-HSA-162582 Signal Transduction
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: B3KX48, B7WP08, C9JAF2, E3UN45, ENST00000416167.1, ENST00000416167.2, ENST00000416167.3, ENST00000416167.4, ENST00000416167.5, ENST00000416167.6, IGF2_HUMAN, NM_000612, P01344, P78449, PP1446, Q14299, Q1WM26, Q9UC68, Q9UC69, uc319lys.1, uc319lys.2
UCSC ID: ENST00000416167.7_14
RefSeq Accession: NM_000612.6
Protein: P01344 (aka IGF2_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene IGF2:
bws (Beckwith-Wiedemann Syndrome)
rss (Silver-Russell Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.