ID:IGBP1_HUMAN DESCRIPTION: RecName: Full=Immunoglobulin-binding protein 1; AltName: Full=B-cell signal transduction molecule alpha 4; Short=Protein alpha-4; AltName: Full=CD79a-binding protein 1; AltName: Full=Protein phosphatase 2/4/6 regulatory subunit; AltName: Full=Renal carcinoma antigen NY-REN-16; FUNCTION: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits. SUBUNIT: Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Interacts with Ubiquitin. INTERACTION: P67775:PPP2CA; NbExp=9; IntAct=EBI-1055954, EBI-712311; P62714:PPP2CB; NbExp=3; IntAct=EBI-1055954, EBI-1044367; P60510:PPP4C; NbExp=7; IntAct=EBI-1055954, EBI-1046072; O00743:PPP6C; NbExp=8; IntAct=EBI-1055954, EBI-359751; SUBCELLULAR LOCATION: Cytoplasm (Potential). TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. DOMAIN: The UIM domain is required for protective effect on PP2A (By similarity). PTM: Phosphorylated (By similarity). PTM: Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive. DISEASE: Defects in IGBP1 are the cause of mental retardation syndromic X-linked type 28 (MRXS28) [MIM:300472]; also known as agenesis of the corpus callosum with mental retardation, ocular coloboma and micrognathia. A syndrome that is characterized by coloboma of the iris and optic nerve, severe retrognathia, intellectual deficit, and agenesis of the corpus callosum. SIMILARITY: Belongs to the IGBP1/TAP42 family. SIMILARITY: Contains 1 UIM (ubiquitin-interacting motif) repeat.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78318
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0019888 protein phosphatase regulator activity GO:0051721 protein phosphatase 2A binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0007165 signal transduction GO:0009966 regulation of signal transduction GO:0032873 negative regulation of stress-activated MAPK cascade GO:0034612 response to tumor necrosis factor GO:0035303 regulation of dephosphorylation GO:0042113 B cell activation GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043666 regulation of phosphoprotein phosphatase activity GO:0060632 regulation of microtubule-based movement GO:0070555 response to interleukin-1
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
