Human Gene IFI44 (ENST00000370747.9_4) from GENCODE V47lift37
  Description: interferon induced protein 44, transcript variant 3 (from RefSeq NR_135641.1)
Gencode Transcript: ENST00000370747.9_4
Gencode Gene: ENSG00000137965.11_7
Transcript (Including UTRs)
   Position: hg19 chr1:79,115,516-79,129,758 Size: 14,243 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr1:79,115,881-79,129,496 Size: 13,616 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:79,115,516-79,129,758)mRNA (may differ from genome)Protein (444 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IFI44_HUMAN
DESCRIPTION: RecName: Full=Interferon-induced protein 44; Short=p44; AltName: Full=Microtubule-associated protein 44;
FUNCTION: This protein aggregates to form microtubular structures (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Potential).
INDUCTION: By alpha and beta interferons, but not by gamma interferons.
SIMILARITY: Belongs to the IFI44 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 73.44 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 394.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.8085-0.209 Picture PostScript Text
3' UTR -46.10262-0.176 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024644 - IFI44_fam
IPR006571 - TLDc

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q8TCB0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0009615 response to virus

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BX537508 - Homo sapiens mRNA; cDNA DKFZp686L21223 (from clone DKFZp686L21223).
LP895709 - Sequence 573 from Patent EP3253886.
JD484536 - Sequence 465560 from Patent EP1572962.
BC022870 - Homo sapiens interferon-induced protein 44, mRNA (cDNA clone MGC:24007 IMAGE:4071404), complete cds.
AK316278 - Homo sapiens cDNA, FLJ79177 complete cds, moderately similar to Interferon-induced protein 44.
AK302527 - Homo sapiens cDNA FLJ56519 complete cds, highly similar to Interferon-induced protein 44.
AK316476 - Homo sapiens cDNA, FLJ79375 complete cds, highly similar to Interferon-induced protein 44.
JD103083 - Sequence 84107 from Patent EP1572962.
CU692744 - Synthetic construct Homo sapiens gateway clone IMAGE:100022000 5' read IFI44 mRNA.
HQ447763 - Synthetic construct Homo sapiens clone IMAGE:100071094; CCSB012800_02 interferon-induced protein 44 (IFI44) gene, encodes complete protein.
JD343472 - Sequence 324496 from Patent EP1572962.
JD083114 - Sequence 64138 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZAG3, D3DQ80, ENST00000370747.1, ENST00000370747.2, ENST00000370747.3, ENST00000370747.4, ENST00000370747.5, ENST00000370747.6, ENST00000370747.7, ENST00000370747.8, IFI44_HUMAN, MTAP44, NR_135641, Q14496, Q8TCB0, uc318ipw.1, uc318ipw.2
UCSC ID: ENST00000370747.9_4
RefSeq Accession: NM_006417.5
Protein: Q8TCB0 (aka IFI44_HUMAN or IF44_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.