Human Gene HTR1B (ENST00000369947.5_7) from GENCODE V47lift37
Description: 5-hydroxytryptamine receptor 1B (from RefSeq NM_000863.3)
Gencode Transcript: ENST00000369947.5_7
Gencode Gene: ENSG00000135312.7_8
Transcript (Including UTRs)
Position: hg19 chr6:78,170,641-78,173,208 Size: 2,568 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr6:78,171,948-78,173,120 Size: 1,173 Coding Exon Count: 1
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: HTR1B
Diseases sorted by gene-association score: prinzmetal's variant angina (17), obsessive-compulsive disorder (13), personality disorder (12), premature ejaculation (11), migraine with or without aura 1 (11), bulimia nervosa (9), borderline personality disorder (9), attention deficit-hyperactivity disorder (8), mood disorder (7), substance abuse (7), alcohol dependence (7), amphetamine abuse (7), substance dependence (6), brunner syndrome (5), pulmonary hypertension (3), schizophrenia (1)
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D012701
Serotonin
C025145
5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole
D005473
Fluoxetine
C090701
GR 127935
D010869
Pindolol
C108518
SB 22489G
D018170
Sumatriptan
C047975
cyanopindolol
C117663
1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine
C065046
3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one
C047087
5-carboxamidotryptamine
C101699
BMS 181101
C052561
CGS 12066B
C097067
CP 94253
D002211
Capsaicin
D003042
Cocaine
C119994
GR 46611
C085632
L 694247
D008711
Metergoline
D008719
Methiothepin
D008784
Methysergide
C478959
N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine
C108531
N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide
D011433
Propranolol
C409045
almotriptan
C100822
alniditan
C075631
anpirtoline
C514241
dihydroethidine
C115647
eletriptan
C106783
naratriptan
C018406
1-(3-trifluoromethylphenyl)piperazine
C112429
2-(((3-(morpholinylmethyl)-2H-chromen-8-yl)oxy)methyl)morpholine
C103477
3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide
C009505
4,4'-diaminodiphenylmethane
D000082
Acetaminophen
D000535
Aluminum
D000643
Ammonium Chloride
D000661
Amphetamine
D045930
Anabolic Agents
C108532
BRL 15572
D002220
Carbamazepine
D004390
Chlorpyrifos
D002794
Choline
D015283
Citalopram
D000242
Cyclic AMP
D003976
Diazinon
D004958
Estradiol
D005492
Folic Acid
D005576
Forskolin
D019833
Genistein
D008715
Methionine
C090413
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
C107225
N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(4-pyridyl)benzamide
D009538
Nicotine
C112854
PNU 109291
D010269
Paraquat
D017374
Paroxetine
D010862
Pilocarpine
D016713
Ritanserin
D013749
Tetrachlorodibenzodioxin
D014635
Valproic Acid
C036042
dicyclohexyl phthalate
C120143
donitriptan
C108128
frovatriptan
C008261
lead acetate
C030589
methylmercury cysteine
C093622
rizatriptan
C005632
tertatolol
C047426
venlafaxine
C089750
zolmitriptan
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF212297 - JP 2014500723-A/19800: Polycomb-Associated Non-Coding RNAs.LF213161 - JP 2014500723-A/20664: Polycomb-Associated Non-Coding RNAs.AK290080 - Homo sapiens cDNA FLJ77883 complete cds, highly similar to Human gene for serotonin 1B receptor.M81590 - Homo sapiens serotonin 1D receptor (5-HT1D~) mRNA, complete cds.BC069065 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone MGC:95339 IMAGE:7216878), complete cds.BC096207 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone MGC:116860 IMAGE:40004711), complete cds.AK315325 - Homo sapiens cDNA, FLJ96361, highly similar to Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B), mRNA.KJ891410 - Synthetic construct Homo sapiens clone ccsbBroadEn_00804 HTR1B gene, encodes complete protein.KR711766 - Synthetic construct Homo sapiens clone CCSBHm_00030806 HTR1B (HTR1B) mRNA, encodes complete protein.BC096206 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone IMAGE:40004708), partial cds.BC096208 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone IMAGE:40004712), partial cds.KJ534870 - Homo sapiens clone HTR1B_iso-A_adult-A14 G protein-coupled 5-hydroxytryptamine serotonin receptor 1B isoform A (HTR1B) mRNA, partial cds, alternatively spliced.AB464442 - Synthetic construct DNA, clone: pF1KB9856, Homo sapiens HTR1B gene for 5-hydroxytryptamine (serotonin) receptor 1B, without stop codon, in Flexi system.MA447874 - JP 2018138019-A/19800: Polycomb-Associated Non-Coding RNAs.MA448738 - JP 2018138019-A/20664: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: ENST00000369947.1, ENST00000369947.2, ENST00000369947.3, ENST00000369947.4, hCG_32414 , HTR1B , NM_000863, uc318hyy.1, uc318hyy.2, X5D7I5, X5D7I5_HUMANUCSC ID: ENST00000369947.5_7RefSeq Accession: NM_000863.3
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.