Human Gene HTR1B (ENST00000369947.5_7) from GENCODE V47lift37
  Description: 5-hydroxytryptamine receptor 1B (from RefSeq NM_000863.3)
Gencode Transcript: ENST00000369947.5_7
Gencode Gene: ENSG00000135312.7_8
Transcript (Including UTRs)
   Position: hg19 chr6:78,170,641-78,173,208 Size: 2,568 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr6:78,171,948-78,173,120 Size: 1,173 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:78,170,641-78,173,208)mRNA (may differ from genome)Protein (390 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HTR1B
Diseases sorted by gene-association score: prinzmetal's variant angina (17), obsessive-compulsive disorder (13), personality disorder (12), premature ejaculation (11), migraine with or without aura 1 (11), bulimia nervosa (9), borderline personality disorder (9), attention deficit-hyperactivity disorder (8), mood disorder (7), substance abuse (7), alcohol dependence (7), amphetamine abuse (7), substance dependence (6), brunner syndrome (5), pulmonary hypertension (3), schizophrenia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.45 RPKM in Artery - Tibial
Total median expression: 35.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.5088-0.381 Picture PostScript Text
3' UTR -382.201307-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  LF212297 - JP 2014500723-A/19800: Polycomb-Associated Non-Coding RNAs.
LF213161 - JP 2014500723-A/20664: Polycomb-Associated Non-Coding RNAs.
AK290080 - Homo sapiens cDNA FLJ77883 complete cds, highly similar to Human gene for serotonin 1B receptor.
M81590 - Homo sapiens serotonin 1D receptor (5-HT1D~) mRNA, complete cds.
BC069065 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone MGC:95339 IMAGE:7216878), complete cds.
BC096207 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone MGC:116860 IMAGE:40004711), complete cds.
AK315325 - Homo sapiens cDNA, FLJ96361, highly similar to Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B), mRNA.
KJ891410 - Synthetic construct Homo sapiens clone ccsbBroadEn_00804 HTR1B gene, encodes complete protein.
KR711766 - Synthetic construct Homo sapiens clone CCSBHm_00030806 HTR1B (HTR1B) mRNA, encodes complete protein.
BC096206 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone IMAGE:40004708), partial cds.
BC096208 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, mRNA (cDNA clone IMAGE:40004712), partial cds.
KJ534870 - Homo sapiens clone HTR1B_iso-A_adult-A14 G protein-coupled 5-hydroxytryptamine serotonin receptor 1B isoform A (HTR1B) mRNA, partial cds, alternatively spliced.
AB464442 - Synthetic construct DNA, clone: pF1KB9856, Homo sapiens HTR1B gene for 5-hydroxytryptamine (serotonin) receptor 1B, without stop codon, in Flexi system.
MA447874 - JP 2018138019-A/19800: Polycomb-Associated Non-Coding RNAs.
MA448738 - JP 2018138019-A/20664: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000369947.1, ENST00000369947.2, ENST00000369947.3, ENST00000369947.4, hCG_32414 , HTR1B , NM_000863, uc318hyy.1, uc318hyy.2, X5D7I5, X5D7I5_HUMAN
UCSC ID: ENST00000369947.5_7
RefSeq Accession: NM_000863.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.