Human Gene HNRNPH1 (ENST00000329433.11_9) from GENCODE V47lift37
  Description: heterogeneous nuclear ribonucleoprotein H1, transcript variant 39 (from RefSeq NM_001395181.1)
Gencode Transcript: ENST00000329433.11_9
Gencode Gene: ENSG00000169045.19_19
Transcript (Including UTRs)
   Position: hg19 chr5:179,041,179-179,050,672 Size: 9,494 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr5:179,041,842-179,050,134 Size: 8,293 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:179,041,179-179,050,672)mRNA (may differ from genome)Protein (472 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: G8JLB6_HUMAN
DESCRIPTION: SubName: Full=Heterogeneous nuclear ribonucleoprotein H;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HNRNPH1
Diseases sorted by gene-association score: precursor t-cell acute lymphoblastic leukemia* (85), hereditary lymphedema (14), lymphedema (8), congenital lymphedema (8), congenital myasthenic syndrome (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 127.61 RPKM in Spleen
Total median expression: 3176.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.20108-0.317 Picture PostScript Text
3' UTR -142.00663-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom
IPR012996 - Znf_CHHC

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF08080 - RNPHF zinc finger

SCOP Domains:
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on G8JLB6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Cellular Component:
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC001348 - Homo sapiens heterogeneous nuclear ribonucleoprotein H1 (H), mRNA (cDNA clone MGC:8619 IMAGE:2961378), complete cds.
GQ901012 - Homo sapiens clone HEL-T-124 epididymis secretory sperm binding protein mRNA, complete cds.
CR749414 - Homo sapiens mRNA; cDNA DKFZp686A15170 (from clone DKFZp686A15170).
L22009 - Human hnRNP H mRNA, complete cds.
AK124530 - Homo sapiens cDNA FLJ42539 fis, clone BRACE3004150, highly similar to Heterogeneous nuclear ribonucleoprotein H.
BX647205 - Homo sapiens mRNA; cDNA DKFZp686D2162 (from clone DKFZp686D2162).
AK092273 - Homo sapiens cDNA FLJ34954 fis, clone NTONG2002582, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H.
AK298193 - Homo sapiens cDNA FLJ54533 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein H.
AB527868 - Synthetic construct DNA, clone: pF1KB0419, Homo sapiens HNRNPH1 gene for heterogeneous nuclear ribonucleoprotein H1, without stop codon, in Flexi system.
AK311021 - Homo sapiens cDNA, FLJ18063.
KJ891373 - Synthetic construct Homo sapiens clone ccsbBroadEn_00767 HNRNPH1 gene, encodes complete protein.
CR456778 - Homo sapiens full open reading frame cDNA clone RZPDo834F084D for gene HNRPH1, heterogeneous nuclear ribonucleoprotein H1 (H); complete cds, incl. stopcodon.
AK307693 - Homo sapiens cDNA, FLJ97641.
JD518314 - Sequence 499338 from Patent EP1572962.
JD494910 - Sequence 475934 from Patent EP1572962.
JD349421 - Sequence 330445 from Patent EP1572962.
DJ418574 - Methods and Compositions for the Specific Inhibition of Gene Expression by Double-Stranded RNA.
HI503955 - Sequence 88 from Patent EP2155772.
HV578814 - JP 2010525813-A/88: Methods and Compositions for the Specific Inhibition of Gene Expression by Double-Stranded RNA.
JB155089 - Sequence 88 from Patent EP2514758.
JD019286 - Sequence 310 from Patent EP1572962.
JD028022 - Sequence 9046 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000329433.1, ENST00000329433.10, ENST00000329433.2, ENST00000329433.3, ENST00000329433.4, ENST00000329433.5, ENST00000329433.6, ENST00000329433.7, ENST00000329433.8, ENST00000329433.9, G8JLB6, G8JLB6_HUMAN, HNRNPH1 , NM_001395181, uc317ssx.1
UCSC ID: ENST00000329433.11_9
RefSeq Accession: NM_001364229.2
Protein: G8JLB6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.