ID:ROA1_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein A1; Short=hnRNP A1; AltName: Full=Helix-destabilizing protein; AltName: Full=Single-strand RNA-binding protein; AltName: Full=hnRNP core protein A1; FUNCTION: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. SUBUNIT: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner. PTM: Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine. PTM: Sumoylated. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09651
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
DL492473 - Novel nucleic acids. DL492474 - Novel nucleic acids. AK298176 - Homo sapiens cDNA FLJ51587 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein A1. BC009600 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:14692 IMAGE:4134638), complete cds. GQ900890 - Homo sapiens clone HEL-T-2 epididymis secretory sperm binding protein mRNA, complete cds. AK303303 - Homo sapiens cDNA FLJ51586 complete cds, moderately similar to Heterogeneous nuclear ribonucleoprotein A1. AK308679 - Homo sapiens cDNA, FLJ98720. AK129814 - Homo sapiens cDNA FLJ26303 fis, clone DMC07819, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1. X06747 - Human hnRNP core protein A1. BC070315 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:88317 IMAGE:4101267), complete cds. D28353 - Homo sapiens mRNA for hnRNP A1, 5'UTR region. AK291113 - Homo sapiens cDNA FLJ75550 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein A1 (HNRPA1), transcript variant 1, mRNA. DL490948 - Novel nucleic acids. BC071945 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:88632 IMAGE:5475712), complete cds. BC078165 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone IMAGE:6179438), with apparent retained intron. BC121133 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:150453 IMAGE:40120894), complete cds. BC073162 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:87898 IMAGE:6154972), complete cds. BC074502 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:65152 IMAGE:3455742), complete cds. BC002355 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:8473 IMAGE:2821751), complete cds. BC033714 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:45574 IMAGE:4420039), complete cds. BC052296 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:59854 IMAGE:6297642), complete cds. BC020442 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone IMAGE:3447644). BC103707 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:102835 IMAGE:6154800), complete cds. X79536 - H.sapiens mRNA for hnRNPcore protein A1. BC012158 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone MGC:20389 IMAGE:4564655), complete cds. JD024469 - Sequence 5493 from Patent EP1572962. U00947 - Human clone C4E 3.2 (CAC)n/(GTG)n repeat-containing mRNA. JD023373 - Sequence 4397 from Patent EP1572962. JD025096 - Sequence 6120 from Patent EP1572962. JD027160 - Sequence 8184 from Patent EP1572962. AB463728 - Synthetic construct DNA, clone: pF1KB8121, Homo sapiens HNRNPA1 gene for heterogeneous nuclear ribonucleoprotein A1, without stop codon, in Flexi system. KJ891371 - Synthetic construct Homo sapiens clone ccsbBroadEn_00765 HNRNPA1 gene, encodes complete protein. CU677924 - Synthetic construct Homo sapiens gateway clone IMAGE:100018904 5' read HNRPA1 mRNA. JD025270 - Sequence 6294 from Patent EP1572962. JD030800 - Sequence 11824 from Patent EP1572962. JD032418 - Sequence 13442 from Patent EP1572962. BC004945 - Homo sapiens, clone IMAGE:3615335, mRNA, partial cds. AX960498 - Sequence 7 from Patent WO03102185. JD022392 - Sequence 3416 from Patent EP1572962. JD026016 - Sequence 7040 from Patent EP1572962. DQ579214 - Homo sapiens piRNA piR-47326, complete sequence. JD035595 - Sequence 16619 from Patent EP1572962. JD027800 - Sequence 8824 from Patent EP1572962. X04347 - Human liver mRNA fragment DNA binding protein UPI homologue (C-terminus). HW916135 - JP 2015503356-A/12: SYSTEM AND METHOD OF DETECTING RNAS ALTERED BY CANCER IN PERIPHERAL BLOOD. BC104236 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone IMAGE:40033043), partial cds. BC104237 - Homo sapiens heterogeneous nuclear ribonucleoprotein A1, mRNA (cDNA clone IMAGE:40033044), partial cds. LF346286 - JP 2014500723-A/153789: Polycomb-Associated Non-Coding RNAs. BC035253 - Homo sapiens, Similar to heterogeneous nuclear ribonucleoprotein A1, clone IMAGE:4754686, mRNA. LF346287 - JP 2014500723-A/153790: Polycomb-Associated Non-Coding RNAs. JD176203 - Sequence 157227 from Patent EP1572962. AX960506 - Sequence 15 from Patent WO03102185. JD377552 - Sequence 358576 from Patent EP1572962. LF346289 - JP 2014500723-A/153792: Polycomb-Associated Non-Coding RNAs. JD196172 - Sequence 177196 from Patent EP1572962. JD370615 - Sequence 351639 from Patent EP1572962. JD178131 - Sequence 159155 from Patent EP1572962. JD462246 - Sequence 443270 from Patent EP1572962. JD344496 - Sequence 325520 from Patent EP1572962. JD026937 - Sequence 7961 from Patent EP1572962. JD030853 - Sequence 11877 from Patent EP1572962. MA581863 - JP 2018138019-A/153789: Polycomb-Associated Non-Coding RNAs. MA581864 - JP 2018138019-A/153790: Polycomb-Associated Non-Coding RNAs. MA581866 - JP 2018138019-A/153792: Polycomb-Associated Non-Coding RNAs. MB422070 - JP 2019162102-A/12: SYSTEM AND METHOD OF DETECTING RNAS ALTERED BY CANCER IN PERIPHERAL BLOOD.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P09651 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-6803523 PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-6803529 FGFR2 alternative splicing R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-5654738 Signaling by FGFR2 R-HSA-72172 mRNA Splicing R-HSA-190236 Signaling by FGFR R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-162582 Signal Transduction
GeneReviews article(s) related to gene HNRNPA1: als-overview (Amyotrophic Lateral Sclerosis Overview) ibmpfd (Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
